Electroanalytical Performance of (SiPy⁺Cl⁻/CuTsPc)₅ LbL Film for Detecting Promethazine Hydrochloride

Abstract

A (SiPy+ Cl À /CuTsPc) 5 layer-by-layer film was employed for the electroanalytical determination of promethazine hydrochloride in BR buffer pH 5.0 with peaks at 0.48 and 0.79 V. After optimisation of the square-wave parameters (f = 100 s À1, a = 40 mV and DE s = 2 mV), the peak at 0.79 V was used for quantification and a detection limit of 8.71 10 À9 mol L À1 and a quantification limit of 9.31 10 À8 were calculated. The applicability of this procedure was tested on commercial formulations of promethazine hydrochloride by observing the stability, specificity, recovery and precision of the procedure in complex samples, without any preliminary treatment.

Estudo eletroquímico do processo de eletrooxidação da prometazina empregando sensor a base de pasta de nanotubos de carbono contendo DNA imobilizado em matriz inorgânica

“…O sensor NTCPM-SiAlNb-DNA apresentou, em baixas velocidades de varredura (15 mVs -1 ), na presença de 1,0 × 10 -3 mol L -1 de PHZ, um δ 0,5 em torno de 50 mV. Este resultado fortemente sugere que dois elétrons participam da reação redox, especialmente porque é conhecido que o mecanismo de eletrooxidação da PHZ em solução ocorrem em duas etapas com a formação de uma espécie intermediária que se oxida posteriormente envolvendo dois elétrons e dois prótons gerando dois picos principais relativamente fracos (JESUS et al, 2011). Aplicando esta relação para o sensor desenvolvido foram encontrados valores de n e como sendo 1,81 elétrons.…”

“…Entre as técnicas eletroanalíticas empregadas para determinação do antidepressivo PHZ cita-se a voltametria cíclica (JESUS, et al, 2011) e a potenciometria (ALIZADE; AKHOUDIAN, 2010). É oportuno mencionar que nestas técnicas fez-se necessário efetuar a modificação química dos eletrodos base com intuito de elevar a detectabilidade e a seletividade do método eletroanalítico.…”

A Novel Electrochemical Sensor Based on Silsesquioxane/Nickel (II) Phthalocyanine for the Determination of Sulfanilamide in Clinical and Drug Samples

“…Metal tetrasulfonated phthalocyanines (M(II)TsPc; M=Fe, Co, Ni, Cu) are a class of water-soluble complexes that present significant potential for use in catalysis. When these complexes are incorporated in a solid matrix, they can be used as a modifier on electrode surfaces, which enables many applications, for example, in the electroanalytical field allowing different applications with an enhancement of electrochemical signal in several modified electrodes [34][35][36][37]. This paper describes the preparation, characterization and use of carbon paste electrodes chemically modified with 3-n-propyl(3-methylpyridinium) silsesquioxane chloride and nickel(II) phthalocyanine-tetrasulfonic acid tetrasodium salt (NiTsPc).…”

“…Metal tetrasulfonated phthalocyanines (M(II)TsPc; M=Fe, Co, Ni, Cu) are a class of water‐soluble complexes that present significant potential for use in catalysis. When these complexes are incorporated in a solid matrix, they can be used as a modifier on electrode surfaces, which enables many applications, for example, in the electroanalytical field allowing different applications with an enhancement of electrochemical signal in several modified electrodes .…”

Amperometric determination of promethazine in tablets using an electrochemically reduced graphene oxide modified electrode

“…These drugs have a tricyclic aromatic ring with sulfur and nitrogen atoms, and different substituents attached at the 2 and 10 or 3 and 7 positions. 12 There are different electrode surfaces which have already been used as detectors for phenothiazine derivative detection, such as the boron-doped diamond, 13 the nanodiamond modified with Ag particles, 14 gold, 15,16 carbon nanotubes, [17][18][19] glassy carbon, 20 FTO modified with SiPy + Cl À and CuTsPc film, 21 and modified carbon paste electrodes. 22,23 To the best of our knowledge, the amperometric detection of promethazine hydrochloride using a rGO modified sensor is reported here for the first time.…”