Electroacupuncture attenuates liver and kidney oxidative stress in anesthetized rats

Silva, Agamenon Honório; Figueiredo, Lanese Medeiros de; Dias, Paulo Araujo; Neto, Alberico Ximenes do Prado; Vasconcelos, Paulo Roberto Leitão de; Guimarães, Sérgio Botelho

doi:10.1590/s0102-86502011000700013

Cited by 9 publications

(7 citation statements)

References 21 publications

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“…Despite the fact that is known that there is a correlation observed between the plasma levels of MDA, and the level of 17-beta estradiol where high levels of this hormone may lead to oxidative stress 27 we cannot exclude the effects of EAc on the increase in lipid peroxidation. We have reported similar results in other tissues in two previous studies [16][17] .…”

Section: U/g Ovarian Tissuesupporting

confidence: 89%

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Effects of acupuncture and electroacupuncture on estradiol-induced inflammation and oxidative stress in health rodents

et al. 2013

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PURPOSE:To investigate the effects of classical acupuncture (Ac) and electroacupuncture (EAc) on estradiol-induced inflammation and oxidative stress in health rodents. METHODS:Twenty-four eight-week old female rats were treated with estradiol valerate (EV) 4.0 mg i.m. single dose and randomly assigned to four groups (n=6): G1(control), G2 (Ac), G3 (EAc 2 Hz) and G4 (EAc 100 Hz). After 60 days all rats were anesthetized with chloral hydrate 10% (0.1 ml/30 g weight of the animal) and submitted to Ac/EAc for twenty minutes. The procedures were repeated on days three, five, seven and nine of the study. The equivalent of the human right ST-36 (Zusanli) and SP-6 (Sanyinjiao) acupoints were chosen for needling and electrical stimulation. On the 10th day of the experiment, all rats were anesthetized for collection of blood and tissues (ovaries) samples for biochemical analysis and histological examination. RESULTS:Glutathione (GSH) and malonaldehyde (MDA) concentrations increased significantly in all groups (plasma and ovary) while myeloperoxidase (MPO) activity decreased significantly in all groups compared with control group (G1). CONCLUSIONS:Both classical acupuncture and electroacupuncture decrease systemic and local oxidative stress and ovary inflammation in healthy rats exposed to estrogenic stimulation. EAc enhances lipid peroxidation at systemic and local levels in female rats exposed to estrogenic stimulation.

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Section: U/g Ovarian Tissuesupporting

confidence: 89%

“…The use of EAc has promoted an increase in GSH levels in the liver and kidneys and in random skin flaps of rats, as demonstrated in previous studies [16][17] . Lipid peroxidation was more intense in rats treated with EAc as there was a significant raise in MDA levels in G3 and G4 rats.…”

Section: Discussionsupporting

confidence: 52%

Effects of acupuncture and electroacupuncture on estradiol-induced inflammation and oxidative stress in health rodents

et al. 2013

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“…Published studies have demonstrated the effects of Ac in attenuating oxidative stress in experimental spinal cord injury 9 and in rats in menopause 10 . Whereas previous studies have proved the attenuating effects of the EAc on the oxidative stress on liver 11 and kidneys 11 , skin 12 , and in the ovaries 3 , it is expected that protection also may occur in rats submitted to testis torsion/detorsion. No similar studies were found in the literature, hence the importance of this investigation.…”

Section: Introductionmentioning

confidence: 87%

Protective effects of abdominal electroacupuncture on oxidative stress and inflammation due to testis torsion/detorsion in rats

Acioli

Albuquerque²,

Guimarães³

et al. 2014

Acta Cir. Bras.

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Conception, design, intellectual and scientific content of the study, critical revision, final approval of the manuscript. ABSTRACT PURPOSE:To evaluate the effects of acupuncture (Ac) and electroacupuncture (EAc) on oxidative stress and inflammation in testis torsion/detorsion (T/D) model in rats. METHODS:Thirty male Wistar rats were randomized into five groups. G1 Group (Sham) served as control. The remaining groups were submitted to spermatic cord torsion (720°) for 3 hours, followed by detorsion and reperfusion for 4 hours. Before detorsion G3, G4 and G5 rats were treated with Ac, EAc 2Hz and EAc 10 Hz, respectively, applied to acupoint Gulai (S-29) bilaterally under anesthesia for 5 minutes. Next, the testes were detorsioned and reperfused for 4 hours. Afterwards, blood samples and the right testis were collected for biochemical assays: reduced Glutathione (GSH), Malonaldehyde (MDA), Myeloperoxidase (MPO). RESULTS:EAc stimulation (2 and 10 Hz) promoted significant increase in concentrations of GSH in plasma and testis of G4-G5 rats, compared with G1. There was significant increase of tissue MDA in groups G4-G5 and plasma MDA in all groups, compared with G1.There was a significant reduction in MPO activity in groups G4-G5 compared with G1. CONCLUSION:Electroacupuncture stimulation (2 and 10 Hz) attenuates oxidative stress and inflammatory response in rats subjected to testicular torsion/detorsion. Key words: Spermatic Cord Torsion. Ischemia. Reperfusion Injury. Electroacupuncture. Rats. Protective effects of abdominal electroacupuncture on oxidative stress and inflammation due to testis torsion/detorsion in rats

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“…In anaesthetized rats, even a single 30-min 10/100 Hz EA session could enhance lipid peroxidation and simultaneously reduce oxidative stress in liver and kidney tissue. 86 EA increases the mean blood flow or perfusion in the liver as well, 87 which may be a benefit to patients undergoing laparoscopic procedures. In endotoxaemic rats, EA at PC6 significantly attenuated elevated biochemical markers of liver and renal injury, markedly decreased the infiltration of neutrophils into liver tissues caused by LPS, and reduced the renal histopathological score.…”

Section: Lungsmentioning

confidence: 99%

Perioperative acupuncture modulation: more than anaesthesia

Lü

Dong

Wang

et al. 2015

British Journal of Anaesthesia

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Accumulated evidences from clinical trials and updated reviews suggest that the role of acupuncture in perioperative medicine extends beyond the classical scope of anaesthesia and has been underestimated. Perioperative acupuncture reduces not only the consumption of anaesthetics and analgesics, but also anaesthesia-related complications, and protects organs in the perioperative period. These beneficial effects make acupuncture a promising approach in perioperative management, especially with respect to enhanced surgery recovery and specific surgical populations, such as elderly patients and 'triple-low' patients. Furthermore, efforts have been made to optimize the clinical application of perioperative acupuncture.

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Electroacupuncture attenuates liver and kidney oxidative stress in anesthetized rats

Cited by 9 publications

References 21 publications

Effects of acupuncture and electroacupuncture on estradiol-induced inflammation and oxidative stress in health rodents

Effects of acupuncture and electroacupuncture on estradiol-induced inflammation and oxidative stress in health rodents

Protective effects of abdominal electroacupuncture on oxidative stress and inflammation due to testis torsion/detorsion in rats

Perioperative acupuncture modulation: more than anaesthesia

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