Electrical stimulation enhances tissue reorganization during orthodontic tooth movement in rats

Spadari, Gisele Sampaio; Zaniboni, Ewerton; Vedovello, Sílvia Amélia Scudeler; Santamaría, Mauro Pedrine; Amaral, Maria Esméria Corezola do; Santos, Gláucia Maria Tech dos; Esquisatto, Marcelo Augusto Marretto; Mendonça, Fernanda Aparecida Sampaio; Santamaria‐Jr, Milton

doi:10.1007/s00784-016-1759-6

Cited by 31 publications

(29 citation statements)

References 60 publications

(70 reference statements)

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“…Our histological findings demonstrated that inflammatory cell infiltaration increased on day 3, reached maximum level on day 7 and then began to decrease. Similar to our study, Spadari et al assessed inflammation and reported that the number of increased granulocytes on day 3 was even higher on day 7 in the tooth movement group.…”

Section: Discussionsupporting

confidence: 90%

“…Orthodontic tooth movement occurs with an inflammatory response, but when this inflammation is not controlled, it can have destructive effects on the teeth and periodontium . Our histological findings demonstrated that inflammatory cell infiltaration increased on day 3, reached maximum level on day 7 and then began to decrease.…”

Section: Discussionmentioning

confidence: 62%

“…Hypoxia is observed in PDL in the early stages of orthodontic tooth movement and VEGF is the most important angiogenesis mediator regulated by hypoxia . According to the qPCR results, this increase in VEGF mRNA level in the tooth movement group on day 7 is due to the hypoxia observed in the tissue with hyalinization and the expression of VEGF is reduced on day 14 with the reestablishment of tissue oxygenation .…”

Section: Discussionmentioning

confidence: 93%

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Influence of omega‐3 fatty acid on orthodontic tooth movement in rats: A biochemical, histological, immunohistochemical and gene expression study

Ogrenim

Cesur

Önal

et al. 2018

Orthod Craniofacial Res

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Structured Abstract Objective The aim of this study was to investigate the effects of omega‐3 fatty acids on orthodontic tooth movement. Setting and Sample Population For this study, 56 12‐week‐old adult male Wistar albino rats from the Animal Laboratory at Adnan Menderes University, Faculty of Medicine, were used. Material and Methods Rats were randomly divided into seven groups (n = 8 each): control group (without any treatment), tooth movement groups (three groups of animals with only tooth movement) and omega groups (three groups of animals with tooth movement and omega‐3 administration). Omega‐3 fatty acids were administered to the rats systemically during the tooth movement period. On the 3rd, 7th and 14th days after the orthodontic tooth movement, the rats were sacrificed and biochemical, histological, immunohistochemical andgene expression examinations were performed. Results On the 14th experimental day, the amount of tooth movement in the omega groups was significantly lower than the tooth movement groups (P = 0.012). Biochemical experimentsshowed that the omega groups had significantly lower total oxidant levels and higher total antioxidant levels compared to the tooth movement group on the 14th experimental day (P = 0.001). The levels of RANKL, IL‐6 and IL‐1β in the omega groups were significantly lower than the tooth movement groups on all experimental days (P < 0.05). Conclusion Systemic administration of omega‐3 fatty acids showed antioxidant and antiinflammatory effects and decelerate the orthodontic tooth movement.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 93%

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Influence of omega‐3 fatty acid on orthodontic tooth movement in rats: A biochemical, histological, immunohistochemical and gene expression study

Ogrenim

Cesur

Önal

et al. 2018

Orthod Craniofacial Res

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“…experimental studies. 4,26,27,28 an commonly used method, 21,27,30,31,32 and micro-CT analyses evaluated bone microarchitecture and BMD.…”

Section: Discussionmentioning

confidence: 99%

Effect of two corticotomy protocols on periodontal tissue and orthodontic movement

et al. 2020

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Effect of two corticotomy protocols on periodontal tissue and orthodontic movement Objective: To compare two corticotomy surgical protocols in rats to verify whether they alter conventional orthodontic movement. Methodology: Sixty Wistar rats were divided into three groups-orthodontic movement (CG), orthodontic movement and corticotomy (G1) and orthodontic movement with corticotomy and decortication (G2)-and euthanized after 7 and 14 days. Tooth movement (mm), bone volume fraction and bone volume ratio to total volume (BV/TV), and bone mineral density (BMD) were evaluated by micro-CT. The total amount of bone was measured in square millimeters and expressed as the percentage of bone area in the histomorphometry. The number of positive TRAP cells and RANK/RANKL/OPG interaction were also investigated. Results: Day 14 showed a statistically significant difference in orthodontic tooth movement in CG compared with G1 (7.52 mm; p=0.009) and G2 (7.36 mm; p=0.016). A micro-CT analysis revealed a difference between CG, G1 and G2 regarding BV/TV, with G1 and G2 presenting a lower BV/TV ratio at 14 days (0.77 and 0.73 respectively); we found no statistically significant differences regarding BMD. There was a difference in the total amount of bone in the CG group between 7 and 14 days. At 14 days, CG presented a significantly higher bone percentage than G1 and G2. Regarding TRAP, G2 had more positive cells at 7 and 14 days compared with CG and G1. Conclusion: Corticotomy accelerates orthodontic movement. Decortication does not improve corticotomy efficiency.

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“…A stainless‐steel closed coil spring was installed between the left upper first molar and the upper incisors, doing tip forward movement of the first molar. The coil spring was stretched from 4 to 6 mm, releasing a 0.4 N initial force …”

Section: Methodsmentioning

confidence: 99%

Zoledronic acid and alendronate sodium and the implications in orthodontic movement

Franzoni

Soares

Zaniboni

et al. 2017

Orthod Craniofacial Res

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Electrical stimulation enhances tissue reorganization during orthodontic tooth movement in rats

Abstract: This technique is used in many areas of medicine, but poorly explored in dentistry and orthodontics. This treatment is cheap and non-invasive and can be applied by own orthodontist, and it can improve the treatment with a faster and safe tooth movement, without pain.

Cited by 31 publications

References 60 publications

Influence of omega‐3 fatty acid on orthodontic tooth movement in rats: A biochemical, histological, immunohistochemical and gene expression study

Influence of omega‐3 fatty acid on orthodontic tooth movement in rats: A biochemical, histological, immunohistochemical and gene expression study

Effect of two corticotomy protocols on periodontal tissue and orthodontic movement

Zoledronic acid and alendronate sodium and the implications in orthodontic movement

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