Electrical impedimetric biosensors for liver function detection

Chuang, Ya-Hsuan; Chang, Yun-Tzu; Liu, Kuo-Liang; Chang, Hwan‐You; Yew, Tri‐Rung

doi:10.1016/j.bios.2011.07.049

Cited by 44 publications

(16 citation statements)

References 19 publications

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“…To date, various HSA detection methods have been developed, such as immunoassay, LC-MS/MS-based proteomics, capillary electrophoresis, colorimetric, and fluorescent probes [12,13,14,15,16,17,18,19,20,21]. In comparison with other detection methods, fluorescent probes are favored because of advantages including a rapid, non-invasive, and sensitive response.…”

Section: Introductionmentioning

confidence: 99%

Development of Human Serum Albumin Selective Fluorescent Probe Using Thieno[3,2-b]pyridine-5(4H)-one Fluorophore Derivatives

Lee

Sung

Kang

et al. 2019

Sensors

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The level of human serum albumin (HSA) in biological fluids is a key health indicator and its quantitative determination has great clinical importance. In this study, we developed a selective and sensitive fluorescent HSA probe by fluorescence-based high-throughput screening of a set of fluorescent thieno[3,2-b]pyridine-5(4H)-one derivatives against major plasma proteins: HSA, bovine serum albumin (BSA), globulin, fibrinogen, and transferrin. The fluorophore chosen finally (4) showed noticeable fluorescence enhancement in the presence of HSA (160-fold increase), and it exhibited rapid response, high sensitivity (detection limit 8 nM), and the ability to clearly distinguish HSA from BSA in pH 9 buffer condition. Moreover, the probe could be applicable to detect trace amounts of HSA in an artificial urine sample; further, it might be applied to the determination of the HSA concentration in complex biological samples for pre-clinical diagnosis.

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Section: Introductionmentioning

confidence: 99%

Development of Human Serum Albumin Selective Fluorescent Probe Using Thieno[3,2-b]pyridine-5(4H)-one Fluorophore Derivatives

Lee

Sung

Kang

et al. 2019

Sensors

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“…Immunosensors were essentially developed for clinical diagnosis, as shown in Table 2 {e.g., detection of human serum albumin [54], cancer biomarkers [56,57,59], infection biomarkers [55], HIV p24 [47], and C-reactive protein [9,10]}.…”

Section: Antibodiesmentioning

confidence: 99%

Recent developments in recognition elements for chemical sensors and biosensors

Justino

Freitas

Pereira

et al. 2015

TrAC Trends in Analytical Chemistry

269

118

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“…Previous research has shown that such kind of biosensor can be used to detect the analyte-element binding stabilized on the surface of an electrode. 84 The binding of an analyte to a bio-element stabilized in a capacitor can directly change the capacitor capacity without the need for labeling. 85 In their study, Rashidiani et al detected nanomolar dilutions of botulinum neurotoxin type A light chain in an aptamer binding in a capacitive cell using an LCR meter (Figure 4).…”

Section: Classification Of Nano-aptasensorsmentioning

confidence: 99%

Nano-Aptasensor: Strategies and Categorizing

et al. 2018

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The rapid detection of agents, toxins, and disease markers is beyond the scope of traditional sampling and detection methods; however, it is possible to solve this problem using biosensors. 1 Aptamers are short fragments of oligonucleotides, peptides, and peptide nucleic acids (PNAs), which, specifically and with high affinity, bind to various biological, organic, and inorganic targets. 2 Aptamers act like pharmaceutical analogues for monoclonal antibodies and have high binding affinity with target molecules. They also have high potential for sensitive and accurate detection. 3 Over the past two decades, nano-biosensors have been widely used in various research and applied fields, including tracking bio-terrorist attacks, clinical diagnoses, drug discovery, human health development, and bio-research, increasingly consolidating their position. The important parts of biosensors include the bio-receptor, signal transducer, signal amplifier, and processor (Figure 1). Biosensors are highly diverse. An aptamer used in a bio-receptor is called an aptasensor, and it is called a nanoaptasensor if nano-methods and nano-materials are used in the construction of the aptasensor. 4-9 A Quick Review of Detection Methods Detection and measurement methods can be divided into three groups: traditional, novel, and hybrid. Traditional methods are based on the biological activity of an analyte or its physiological effects on living cells or animals and include methods of investigating animal behavior, animal feeding, 10 physiological responses, 11 the use of cell culture, and immunological methods. 12 Novel methods include radio immunoassay, immunodiffusion, ELISA, ELISA-ALIKA, PCR, etc. 13 These methods are not optimal now and have many shortcomings, e.g., low detection potential, high cost, complicated procedures, long processing times, and the need for space and skilled personnel. 3,14 Recently, more accurate and simpler sensing methods have emerged with advancements made in other fields and the scientific convergence created in the form of interdisciplinary sciences. 15,16 Biosensors (Definitions and History) A biosensor is a tool that uses specific biochemical interactions to measure an analyte. This reaction results in the production of a signal; if recorded, amplified, and read, the analyte can be tracked and measured (Figure 1). 17 The use of canaries by miners to detect contamination or lethal doses of carbon monoxide in mines is considered as the first application of biosensors. The idea of using a sensor to measure human bioanalytes was raised in the early twentieth century, but electrodes or probes were used until the 1970s. The first generation of biosensors measured analytes such as sugar in

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Electrical impedimetric biosensors for liver function detection

Cited by 44 publications

References 19 publications

Development of Human Serum Albumin Selective Fluorescent Probe Using Thieno[3,2-b]pyridine-5(4H)-one Fluorophore Derivatives

Development of Human Serum Albumin Selective Fluorescent Probe Using Thieno[3,2-b]pyridine-5(4H)-one Fluorophore Derivatives

Recent developments in recognition elements for chemical sensors and biosensors

Nano-Aptasensor: Strategies and Categorizing

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