Recent developments in recognition elements for chemical sensors and biosensors

Justino, Celine I.L.; Freitas, Ana C.; Pereira, Ruth; Duarte, Armando C.; Rocha-Santos, Teresa

doi:10.1016/j.trac.2015.03.006

Cited by 268 publications

(130 citation statements)

References 125 publications

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“…There is, however, a significant disadvantage of antibodies when it comes to direct detection of the analyte because their relatively large size sets a large distance between the analyte and the substrate. There are other capturing molecules that are gaining some attention such as enzymes, molecularly imprinted polymers, and affimers [151][152][153]. While they hold promise for functional SERS assays, they have yet to gain momentum for both research and real-world applications.…”

Section: Functional Assaysmentioning

confidence: 99%

Fundamentals and applications of SERS-based bioanalytical sensing

et al. 2017

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Abstract:Plasmonics is an emerging field that examines the interaction between light and metallic nanostructures at the metal-dielectric interface. Surface-enhanced Raman scattering (SERS) is a powerful analytical technique that uses plasmonics to obtain detailed chemical information of molecules or molecular assemblies adsorbed or attached to nanostructured metallic surfaces. For bioanalytical applications, these surfaces are engineered to optimize for high enhancement factors and molecular specificity. In this review we focus on the fabrication of SERS substrates and their use for bioanalytical applications. We review the fundamental mechanisms of SERS and parameters governing SERS enhancement. We also discuss developments in the field of novel SERS substrates. This includes the use of different materials, sizes, shapes, and architectures to achieve high sensitivity and specificity as well as tunability or flexibility. Different fundamental approaches are discussed, such as label-free and functional assays. In addition, we highlight recent relevant advances for bioanalytical SERS applied to small molecules, proteins, DNA, and biologically relevant nanoparticles. Subsequently, we discuss the importance of data analysis and signal detection schemes to achieve smaller instruments with low cost for SERS-based point-of-care technology developments. Finally, we review the main advantages and challenges of SERS-based biosensing and provide a brief outlook.

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Section: Functional Assaysmentioning

confidence: 99%

Fundamentals and applications of SERS-based bioanalytical sensing

et al. 2017

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“…It sounds weird but the reader may agree with me that this is the basics of a sensor. Shortly, in (bio) chemical sensors [25] the analytes are isolated from the sample matrix into the receptor due to chemical interactions producing a change that is transduced into a signal. In this case, the elution is called regeneration step and it is necessary to reuse the sensor.…”

Section: Extraction Without Elutionmentioning

confidence: 99%

Making biosamples compatible with instrumental analysis

Lucena¹

2015

J Appl Bioanal

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“…Usually two different approaches can be applied in the measurement of analytes by means of enzymatic biosensor: (i) the target analyte is the substrate for enzyme and the product of enzymatic reaction is measured; (ii) the target analyte acts as the inhibitor of enzyme and the decrease of the enzymatic product formation is measured and correlated to the concentration of target analyte 6,7 . The schematic representation of enzyme biosensor is shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Cholinesterase-based biosensors

Štěpánková

Vorčáková

2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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Recently, cholinesterase-based biosensors are widely used for assaying anticholinergic compounds. Primarily biosensors based on enzyme inhibition are useful analytical tools for fast screening of inhibitors, such as organophosphates and carbamates. The present review is aimed at compilation of the most important facts about cholinesterase based biosensors, types of physico-chemical transduction, immobilization strategies and practical applications.

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Recent developments in recognition elements for chemical sensors and biosensors

Cited by 268 publications

References 125 publications

Fundamentals and applications of SERS-based bioanalytical sensing

Fundamentals and applications of SERS-based bioanalytical sensing

Making biosamples compatible with instrumental analysis

Cholinesterase-based biosensors

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