ELASTICITY OF HUMAN SKIN <i>IN VIVO</i>

Grahame, Rodney

doi:10.1093/rheumatology/10.3.130

Cited by 11 publications

(17 citation statements)

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“…Considering correction factors of 2 and 5 for dermal and hypodermal velocities due to diffraction biases, the corresponding shear modulus ranges from 1.20 to 3.10 MPa in the dermis and 3.10 to 9.68 kPa in the hypodermis. The results are in good agreement with the literature [21]- [23]. The shape of the phase delay is always the same as in Fig.…”

Section: In-vivo Experimentssupporting

confidence: 92%

“…Moreover, some shear elasticity measurements attribute a very strong Young's modulus of the order of 1 MPa to the skin [21]- [23]. Thus, the shear wave velocity is roughly 30 m/s in the dermis (E ≈ 3ρV 2 S ).…”

Section: A Adaptation Of the Shear Elasticity Probementioning

confidence: 99%

“…The simulation parameters in the dermis and hypodermis are fixed from results found in the literature [21]- [23]. Thus, shear wave speeds of 3 m/s, 30 m/s, and 3 m/s are recorded for each respective layer.…”

Section: Validation Of the Sonoelastography Technique By Numericalmentioning

confidence: 99%

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Assessment of elastic parameters of human skin using dynamic elastography

Gennisson

Baldeweck

Tanter

et al. 2004

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

129

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Sonoelastography and transient elastography are two ultrasound-based techniques that facilitate noninvasive characterization of the viscoelastic properties of soft tissues by investigating their response to shear mechanical excitation. Young's modulus is the principle assessment parameter. Because it defines local tissue stiffness, it is of major interest for the medical imaging and cosmetic industries as it could replace subjective palpation by yielding local, quantitative information. In this paper, we describe a new high-resolution device capable of measuring local Young's modulus in very thin layers (1-5 mm) and devoted to the in vivo evaluation of the elastic properties of human skin. It uses an ultrasonic probe (50 MHz) for tracking the displacements induced by a 300 Hz shear wave generated by a ring surrounding the transducer. The displacements are measured using a conventional cross-correlation technique between successive ultrasonic back-scattered echoes. First, this noninvasive technique has been experimentally proven to be accurate for investigating elasticity in different skinmimicking phantoms. Second, data were acquired in vivo on human forearms. As expected, Young's modulus was found to be higher in the dermis than in the hypodermis and other soft tissues.

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Section: In-vivo Experimentssupporting

confidence: 92%

Section: A Adaptation Of the Shear Elasticity Probementioning

confidence: 99%

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Assessment of elastic parameters of human skin using dynamic elastography

Gennisson

Baldeweck

Tanter

et al. 2004

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

129

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“…Effect of Some Adrenal Steroid Hormones on Skin Fibroblast Replication in vitro. By W. HARVEY and R. GRAHAME (Guy's Hospital Medical School, London) We have previously drawn attention to the fact that, in patients suffering from rheumatoid arthritis, the familiar steroid-induced skin-thinning effect which occurs in those given long-term oral corticosteroid medication is absent in those treated with ACTH- (Grahame, 1969). This observation is compatible with the earlier observations of Savage, Copeman, Chapman, Wells, and Treadwell (1962) and West (1961) that 'steroid bruising' is rare in ACTHtreated rheumatoid arthritis patients.…”

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confidence: 99%

Effect of some adrenal steroid hormones on skin fibroblast replication in vitro.

Harvey¹,

Grahame²

1973

Annals of the Rheumatic Diseases

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We have previously drawn attention to the fact that, in patients suffering from rheumatoid arthritis, the familiar steroid-induced skin-thinning effect which occurs in those given long-term oral corticosteroid medication is absent in those treated with ACTH- (Grahame, 1969). This observation is compatible with the earlier observations of Savage, Copeman, Chapman, Wells, and Treadwell (1962) and West (1961) that 'steroid bruising' is rare in ACTHtreated rheumatoid arthritis patients. This study was undertaken to investigate this apparent disparity of effect between ACTH and oral corticosteroids.It is well established that in vitro corticosteroids (including synthetic analogues) inhibit fibroblast growth and replication (Berliner, Bartley, Kenner, and Jee, 1970). It follows that the 'protective' effect of ACTH could be due to a direct effect of ACTH itself, or perhaps to the effect of androgenic steroids released by the adrenal cortex in response to ACTH stimulation, since it has been shown that the skin of hirsute women is thicker and contains more collagen (Shuster, Black, and Bottoms, 1970) and that their urine contains increased amounts of testosterone (Nabarro, personal communication

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“…in right or left palmar contact area for better or worse during the assessment period was considered significant. In order to investigate more accurately the physical properties of the skin in this disease, a suction cup was applied to the intact skin of the dorsum of the right hand and the distortion produced in response to a series of pre-determined negative pressures was measured (Grahame and Holt, 1969) (Fig. 1).…”

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confidence: 99%