Elastic fiber changes induced by penicillamine

‘Swiss Cheese’ Lymphangiectasia in a Case of Solitary Morphea Profunda

“…Tuffanelli (5) reported three patients with systemic scleroderma and vesicles, supporting Templeton's view. In contrast, Bardach and Gebhart (9) suggested that these dilated vascular channels may be a result of defective connective tissue support of the dermal vasculature. Hashimoto et al (8) believed that defective formation of the internal elastic membrane may be responsible.…”

“…Reports of lymphangiectasia in lesions of scleroderma are rare (3)(4)(5)(6)(7). No explanation of the exact mechanism by which lymphang-iectasia develops in the morphea exists at the present time, although several theories have been proposed (3)(4)(5)(6)(7)(8)(9)(10). Templeton et al (3) were first to suggest that the bullous lesions might be due to lymphatic obstruction caused by the sclerodermatous process, particularly in the papillary dermis.…”

“…Reports oflymphangiectases that occur in lesions of morphea are rare (3..., 7). Definitive causes of the lymphatic dilatation in these cases are uncertain, but several theories have been proposed to explain the pathogenesis (3)(4)(5)(6)(7)(8)(9)(10). In this report, we report the occurrence of lymphangiectasiaand milium in a patient with a solitary morphea profunda.…”

Fifty shades of yellow: a review of the xanthodermatoses

“…Interestingly 40% of cases are associated with a connective tissue disease including Down's syndrome, Ehlers–Danlos syndrome, Marfan's syndrome, osteogenesis imperfecta, scleroderma, and PXE . It is also known to occur secondary to D‐penicillamine through a process of abnormal elastin production …”

“…By contrast with other forms of xanthoma, they are correlated with hypertriglyceridemia and regress rapidly after correction of the elevated triglyceride levels. Eruptive xanthomas tend to occur only when triglyceride levels exceed 20 mmol/l (1771 mg/dl), and patients typically have other manifestations of systemic disease related to their lipid disorder, such as cardiac, renal, or retinal pathology . They are also commonly seen in poorly‐controlled type 1 diabetes.…”