Eine neue Nanofaser-Matrix für den kornealen Gewebeersatz

Salehi, Sahar; Grünert, A.; Bahners, Thomas; Gutmann, Jochen S.; Steuhl, K.–P.; Czugala, Marta; Singer, Bernhard B.; Fuchsluger, Thomas Armin

doi:10.1055/s-0034-1368533

Cited by 6 publications

(2 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PGS membranes have been used to isolate donor photoreceptor layers in vitro as well as to selectively remove host photoreceptors in vivo. 53 Satisfactory cell viability was observed after 7 days of cultivation with no apparent toxicity based on the MTT assay data. PGS membranes with electrospun nanofibers of laminin and PCL stimulated adequate cell adhesion for concurrent relocation of sequestered photoreceptor layers.…”

Section: Pgs For Biomedical Applications a Pgs For Ophthalmology Appmentioning

confidence: 92%

“…52 Further biocompatibility tests of the material was carried out in vitro by the MTT assay on days 3, 5, and 7 to test the cell viability of HCECs. 53 Satisfactory cell viability was observed after 7 days of cultivation with no apparent toxicity based on the MTT assay data. Apoptotic assessments by FACS analysis showed that no composition stimulated apoptosis or activated PBMCs occurred.…”

Section: Pgs For Biomedical Applications a Pgs For Ophthalmology Appl...mentioning

confidence: 92%

See 1 more Smart Citation

Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

2015

View full text Add to dashboard Cite

The recently developed poly(glycerol sebacate) (PGS) has been gaining attraction as a biomaterial for tissue engineering applications. Reported in 2002, a simple polycondensation method was developed to synthesize PGS for soft tissue engineering applications. It has since become a highly sought after biomaterial due to its soft, robust and flexible characteristics and it is relatively low cost compared to other biodegradable elastomers currently available in the market. We summarise in this review, the various synthetic approaches of PGS and highlight selected applications in nerve guidance, soft tissue regeneration, vascular and myocardial tissue regeneration, blood vessel reconstruction, drug delivery, and the replacement of photoreceptor cells. A critical assessment of the material is provided as a scope for future improvement. The future outlook of this material is also provided at the end of this review.

show abstract

Section: Pgs For Biomedical Applications a Pgs For Ophthalmology Appmentioning

confidence: 92%

Section: Pgs For Biomedical Applications a Pgs For Ophthalmology Appl...mentioning

confidence: 92%

Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

2015

View full text Add to dashboard Cite

show abstract

Neue Möglichkeiten der Augenoberflächenrekonstruktion

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

Korneale Zelltherapie – Eine Übersicht

et al. 2017

View full text Add to dashboard Cite

In recent years, the cultivation and expansion of primary corneal cells has made significant progress. The transplantation of cultured limbal epithelial cells represents a successful and established treatment of the ocular surface. Cultivated corneal endothelial cells are undergoing a clinical trial in Japan. Stromal keratocytes can now be expanded in vitro. A wide range of stem cell sources is being tested in vitro and animal models for their possible application in corneal cell therapy. This article gives an overview of recent advancements and prevailing limitations for the use of different cell sources in the therapy of corneal disease.

show abstract

Eine neue Nanofaser-Matrix für den kornealen Gewebeersatz

Abstract: A tissue-like scaffold mimicking the human stroma could be developed. The results indicate that PGS/PCL scaffolds could be considered as ideal candidates for corneal tissue engineering as they are biocompatible in contact to corneal endothelial cells and blood cells.

Cited by 6 publications

References 40 publications

Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

Neue Möglichkeiten der Augenoberflächenrekonstruktion

Korneale Zelltherapie – Eine Übersicht

Contact Info

Product

Resources

About