New technologies rely on the development of new materials, and these may simply be the innovative combination of known components. The structural combination of a polymer hydrogel network with a nanoparticle (metals, non‐metals, metal oxides, and polymeric moieties) holds the promise of providing superior functionality to the composite material with applications in diverse fields, including catalysis, electronics, bio‐sensing, drug delivery, nano‐medicine, and environmental remediation. This mixing may result in a synergistic property enhancement of each component: for example, the mechanical strength of the hydrogel and concomitantly decrease aggregation of the nanoparticles. These mutual benefits and the associated potential applications have seen a surge of interest in the past decade from multi‐disciplinary research groups. Recent advances in nanoparticle–hydrogel composites are herein reviewed with a focus on their synthesis, design, potential applications, and the inherent challenges accompanying these exciting materials.
In situ gel delivery systems are preferred over conventional systems due to sustained and prolonged release action of therapeutic payload onto the targeted site. Thermogel, a form of in situ gel-forming polymeric formulation, undergoes sol–gel transition after administration into the body. At room temperature, the system is an aqueous polymer solution that easily entraps therapeutic payload by mixing. Upon injection, the higher physiological temperature causes gelation in situ because of the presence of thermosensitive polymers. The gel degrades gradually over time, allowing sustained release of therapeutics localized to the site of interest. This minimizes systemic toxicity and improved efficacy of drug release to the targeted site. Thermogel properties can be easily altered for specific applications via substitution and modification of components in diblock and triblock copolymer systems. The feasibility of fine-tuning allows modifications to biodegradability, biocompatibility, biological functionalization, mechanical properties, and drug release profile. This review summarized recent development in thermogel research with a focus on synthesis and self-assembly mechanisms, gel biodegradability, and applications for drug delivery, cell encapsulation and tissue engineering. This review also assessed inadequacy of material properties as a stand-alone factor on therapeutic action efficacy in human trials, with a focus on OncoGel, an experimental thermogel that demonstrated excellent individual or synergistic drug delivery system in preclinical trials but lacked therapeutic impact in human trials. Detailed analysis from all aspects must be considered during technology development for a successful thermogel platform in drug delivery and tissue engineering.
The recently developed poly(glycerol sebacate) (PGS) has been gaining attraction as a biomaterial for tissue engineering applications. Reported in 2002, a simple polycondensation method was developed to synthesize PGS for soft tissue engineering applications. It has since become a highly sought after biomaterial due to its soft, robust and flexible characteristics and it is relatively low cost compared to other biodegradable elastomers currently available in the market. We summarise in this review, the various synthetic approaches of PGS and highlight selected applications in nerve guidance, soft tissue regeneration, vascular and myocardial tissue regeneration, blood vessel reconstruction, drug delivery, and the replacement of photoreceptor cells. A critical assessment of the material is provided as a scope for future improvement. The future outlook of this material is also provided at the end of this review.
The development of functional polymers from renewable lignin is attractive due to the depletion of fossil fuel and increasing environmental usage. A series of poly(ethylene glycol) methyl ether methacrylate (PEGMA)-grafted lignin hyperbranched copolymers were prepared by atom transfer radical polymerization (ATRP). The chemical structures, molecular characteristic and thermal properties of these copolymers were evaluated and such copolymers were prepared in a range of molecular weights from 38.7 to 65.0 kDa by adjusting the PEGMA-to-lignin weight ratio. As a result from their hyperbranch architecture, their aqueous solutions were found to form supramolecular hydrogels with a very low critical gelation concentration of 1 wt % copolymers, in the presence of α-cyclodextrin (α-CD). The rheological properties of the supramolecular assemblies were investigated and these hydrogel systems showed tunable mechanical response and excellent self-healing capability. Combined with good biocompatibility, these new types of green supramolecular hydrogels based on lignin−PEGMA/cyclodextrin inclusion are potentially useful as a smart biomaterial for biomedical application.
Recent advances in host–guest chemistry have significantly influenced the construction of supramolecular soft biomaterials. The highly selective and non‐covalent interactions provide vast possibilities of manipulating supramolecular self‐assemblies at the molecular level, allowing a rational design to control the sizes and morphologies of the resultant objects as carrier vehicles in a delivery system. In this Focus Review, the most recent developments of supramolecular self‐assemblies through host–guest inclusion, including nanoparticles, micelles, vesicles, hydrogels, and various stimuli‐responsive morphology transition materials are presented. These sophisticated materials with diverse functions, oriented towards therapeutic agent delivery, are further summarized into several active domains in the areas of drug delivery, gene delivery, co‐delivery and site‐specific targeting deliveries. Finally, the possible strategies for future design of multifunctional delivery carriers by combining host–guest chemistry with biological interface science are proposed.
Pluronic F127 exhibits thermogelling behaviour at 20-30 • C via a micelle packing mechanism. Disruption of the micelle packing increases the sol-gel temperature, but results in the decrease of modulus. Herein, we reported a method to modify F127 with polyhedral oligosilsesquioxane (POSS) to impart a higher gelling temperature without yielding the property and strength of the thermogel. The thermal degradation temperature was enhanced to 15 • C after POSS incorporation and the gelling temperature shifted 10 • C higher, without sacrificing the modulus of the gel. Rheological studies supported the claim that the gel property was reinforced after POSS incorporation. F127-POSS copolymer matrix stored more energy from POSS reinforcement, which saw larger Lissajous curve areas before the collapse of the microstructure for the same amount of stress applied. These results indicated that modification with POSS would raise the sol-gel transition temperature without sacrificing the modulus of the gel.
Polymeric micelles are used as 'smart drug carriers' for targeting certain areas of the body by making them stimuli-sensitive or by attachment of a specific ligand molecule onto their surface. The main aim of using polymeric micelles is to deliver the poorly water soluble drugs. Now-a-days they are used especially in the areas of cancer therapy also. In this article we have reviewed several aspects of polymeric micelles concerning their mechanism of formation, chemical nature, preparation and characterization techniques, and their applications in the areas of drug delivery.
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