Polymeric Micelles as Novel Carriers for Poorly Soluble Drugs— Review

Abstract

Polymeric micelles are used as 'smart drug carriers' for targeting certain areas of the body by making them stimuli-sensitive or by attachment of a specific ligand molecule onto their surface. The main aim of using polymeric micelles is to deliver the poorly water soluble drugs. Now-a-days they are used especially in the areas of cancer therapy also. In this article we have reviewed several aspects of polymeric micelles concerning their mechanism of formation, chemical nature, preparation and characterization techniques, and their applications in the areas of drug delivery.

Ascorbyl palmitate/d-α-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo

“…The biocompatible polymeric corona causes reduced recognition of the micelles by reticuloendothelial systems, thus providing prolonged circulation of the loaded component in the blood stream. 22,23 The nanoranged size along with the prolonged circulatory property allows mixed micelles to eventually accumulate in any compromised tissue vasculature sites, eg, tumor via a passive targeting phenomenon commonly referred to as enhanced permeability and retention effect. 20,22,24 Therefore, the overarching aim of the current study was to design a novel AP/TPGS mixed micellar system and investigate its potential targeted therapeutic effect in treating lung cancer in vitro and in vivo.…”

“…22,23 The nanoranged size along with the prolonged circulatory property allows mixed micelles to eventually accumulate in any compromised tissue vasculature sites, eg, tumor via a passive targeting phenomenon commonly referred to as enhanced permeability and retention effect. 20,22,24 Therefore, the overarching aim of the current study was to design a novel AP/TPGS mixed micellar system and investigate its potential targeted therapeutic effect in treating lung cancer in vitro and in vivo. The AP/TPGS mixed micelles of CK could enhance the water solubility and permeability of CK, prolong its retention time, and promote its accumulation in tumor tissues.…”

Surface Charge Reversible Polymeric Micelle‐Laden Hydrogels for Drug Delivery and 3D Cell Culture

“…However, loading hydrophobic drugs into the hydrogels homogeneously remains a challenge due to the hydrophilic nature of the hydrogels . It is well known that polymeric micelles could increase the solubility of hydrophobic drugs and control the release rate of hydrophobic drugs . Polymeric micelles laden hydrogels combine the advantages of polymeric micelles and the hydrogels for prolonging the release time of the drugs and improving the treatment effect of the drugs .…”

An 8-hydroxyquinoline-containing polymeric micelle system is effective for the treatment of murine tegumentary leishmaniasis

“…Studies performed on the development of systems composed of polymeric micelle are rapidly growing. The physicochemical properties of these products make them well suited for the drug delivery of challenging molecules from different perspectives (Glisoni and Sosnik 2014;Brugués et al 2015;Reddy et al 2015;Rongbin et al 2016;Chen et al 2016). In this context, the present study evaluated an 8-HQN-containing polymeric micelle system to treat L. amazonensis-infected BALB/c mice.…”