Ein neues Catechinglykosid aus Polypodium vulgare / A New Catechin Glycoside from Polypodium vulgare

Karl, Christian; Müller, Gerhard; Pedersen, Peter Alsted

doi:10.1515/znc-1982-3-402

Cited by 18 publications

(1 citation statement)

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“…Chemical composition. Flavonoids (Grzybek, 1976;Karl et al, 1982); hydroxycinnamic acids (caffeic acid 4'-glucoside, 0.6% in the rhizome) (Jizba and Herout, 1967;Grzybek, 1976); phytoecdysteroids (Arai et al, 1991;Yamada et al, 1992;Marco et al, 1993;Coll et al, 1994;Reixach et al, 1996;Messeguer et al, 1998;Simon et al, 2011); triterpenes (Devys et al, 1969;Robinson et al, 1973;EMA, 2008b).…”

Section: Polypodium Vulgare L -Polypodiaceae (Rhizomes)mentioning

confidence: 99%

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

et al. 2020

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Background: Current recommendations for the self-management of SARS-Cov-2 disease (COVID-19) include self-isolation, rest, hydration, and the use of NSAID in case of high fever only. It is expected that many patients will add other symptomatic/adjuvant treatments, such as herbal medicines. Aims: To provide a benefits/risks assessment of selected herbal medicines traditionally indicated for "respiratory diseases" within the current frame of the COVID-19 pandemic as an adjuvant treatment. Method: The plant selection was primarily based on species listed by the WHO and EMA, but some other herbal remedies were considered due to their widespread use in respiratory conditions. Preclinical and clinical data on their efficacy and safety were collected from authoritative sources. The target population were adults with early and mild flu symptoms without underlying conditions. These were evaluated according to a modified PrOACT-URL method with paracetamol, ibuprofen, and codeine as reference drugs. The benefits/risks balance of the treatments was classified as positive, promising, negative, and unknown. Results: A total of 39 herbal medicines were identified as very likely to appeal to the COVID-19 patient. According to our method, the benefits/risks assessment of the herbal medicines was found to be positive in 5 cases (Althaea officinalis, Commiphora molmol, Glycyrrhiza glabra, Hedera helix, and Sambucus nigra), promising in 12 cases (Allium sativum, Andrographis paniculata, Echinacea angustifolia, Echinacea purpurea, Eucalyptus globulus essential oil, Justicia pectoralis, Magnolia officinalis, Mikania glomerata, Pelargonium sidoides, Pimpinella anisum, Salix sp, Zingiber officinale), and unknown for the rest. On the same grounds, only ibuprofen resulted promising, but we could not find compelling evidence to endorse the use of paracetamol and/or codeine. Conclusions: Our work suggests that several herbal medicines have safety margins superior to those of reference drugs and enough levels of evidence to start a clinical

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