Efficient microwave synthesis, functionalisation and biocompatibility studies of SPION based potential nano-drug carriers

Saxena, Namita; Dholia, Neeraj; Satyaprasad, A.; Singh, Anupinder; Yadav, Umesh C. S.; Dube, Charu Lata

doi:10.1007/s13204-019-01153-8

Cited by 9 publications

(4 citation statements)

References 39 publications

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“…Among them, superparamagnetic iron oxide nanoparticles (SPIONs) obtained low remanence and coercivity to prevent caking, which is conducive to maintaining long-term circulation in the body. 114 The combination of HAP nanorods and superparamagnetic Fe 3 O 4 nanoparticles can form a dual-phase Fe 3 O 4 /HAP composite with high saturation magnetization of 18 emu g −1 . 115 Due to their low coercivity, large specific surface area, high mesoporous volume, and good magnetism, Fe 3 O 4 /HAP composites are suitable for targeted DDS.…”

Section: Drug Release Responsiveness Of Hap-based Carriersmentioning

confidence: 99%

Hydroxyapatite-based carriers for tumor targeting therapy

Qian

Xiong

2023

RSC Adv.

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Section: Drug Release Responsiveness Of Hap-based Carriersmentioning

confidence: 99%

Hydroxyapatite-based carriers for tumor targeting therapy

Qian

Xiong

2023

RSC Adv.

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“…The A similar agreement is shown in panels (e) and (f) for vertex magnetization (M V ) and remanence (M R ). Both properties play important roles in many recent applications of magnetic materials: the vertex magnetization is proportional to the amplitude of the induced voltage signal and can therefore be used to determine, for a given magnetic nanomaterial, the minimum concentration needed to get a measurable signal [64]; on the other hand, magnetic remanence of nanoparticles is very sensitive to physical and chemical effects such as dipole-dipole interactions among distant particles, magnetic contact interactions and magnetic coherence length [65] in aggregated particles, interfacial coupling between particles and non-magnetic entities, such as molecules decorating the particle surface and/or functionalization agents [66], and can therefore be used to monitor changes with time of nanoparticle concentration, degree of aggregation, surface coverage both in vitro and in vivo.…”

Section: Hysteresis Loop Parametersmentioning

confidence: 99%

From spectral analysis to hysteresis loops: a breakthrough in the optimization of magnetic nanomaterials for bioapplications

Barrera

Tiberto

2023

J. Phys. Mater.

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An innovative method is proposed to determine the most important magnetic properties of bioapplication-oriented magnetic nanomaterials exploiting the connection between hysteresis loop and frequency spectrum of magnetization. Owing to conceptual and practical simplicity, the method may result in a substantial advance in the optimization of magnetic nanomaterials for use in precision medicine. The techniques of frequency analysis of the magnetization currently applied to nanomaterials both in vitro and in vivo usually give a limited, qualitative picture of the effects of the active biological environment on magnetic tracers, and have to be complemented by direct measurement of the hysteresis loop. We show that the very same techniques can be used to convey all the information needed by present-day biomedical applications without the necessity of doing conventional magnetic measurements in the same experimental conditions. The spectral harmonics obtained analyzing the response of a magnetic tracer in frequency, as in Magnetic Particle Spectroscopy/Imaging (MPS/MPI), are demonstrated to lead to a precise reconstruction of the hysteresis loop, whose most important parameters (loop's area, magnetic remanence and coercive field) are directly obtained through transformation formulas based on simple manipulation of the harmonics amplitudes and phases.The validity of the method is experimentally verified on various magnetic nanomaterials for bioapplications submitted to ac magnetic fields of different amplitude, frequency and waveshape. In all cases, the experimental data taken in the frequency domain exactly reproduce the magnetic properties obtained from conventional magnetic measurements.

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“…Some of the disadvantages that are seen in such type of formulation are that only small-sized molecules can be entrapped especially having mass less than 500 Dalton (Da), so drug delivery of large-sized molecules is not feasible. Degree of crystallization affects drug loading [25]. There is also a possibility of dose dumping, which can be improved by use of polymer blends which will help in encapsulation of compounds with higher molecular mass [26].…”

Section: Introductionmentioning

confidence: 99%

The ascension of nanosponges as a drug delivery carrier: preparation, characterization, and applications

Tiwari

Bhattacharya

2022

J Mater Sci: Mater Med

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Nanosponges are nanosized drug carriers with a three-dimensional structure created by crosslinking polymers. They have the advantage of being able to hold a wide range of drugs of various sizes. Nanosponges come in a variety of shapes and sizes. They are distinguished by the research method used, the type of polymer used, and the type of drug they may contain. Nanosponges are superior to other delivery systems because they can provide a controlled drug release pattern with targeted drug delivery. The period of action, as well as the drug’s residence time, may be regulated. Since it is made of biodegradable materials, it has a low toxicity and is safe to use. The efficiency of drug encapsulation is determined by the size of the drug molecule and the amount of void space available. Cancer, enzyme and biocatalyst carrier, oxygen delivery, solubility enhancement, enzyme immobilization, and poison absorbent are some of the applications for nanosponges. The method of preparation, characterization, factors affecting nanosponge development, drug loading and release mechanism, recent developments in this area, and patents filed in the area of nanosponges are all highlighted in this study.

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Efficient microwave synthesis, functionalisation and biocompatibility studies of SPION based potential nano-drug carriers

Cited by 9 publications

References 39 publications

Hydroxyapatite-based carriers for tumor targeting therapy

Hydroxyapatite-based carriers for tumor targeting therapy

From spectral analysis to hysteresis loops: a breakthrough in the optimization of magnetic nanomaterials for bioapplications

The ascension of nanosponges as a drug delivery carrier: preparation, characterization, and applications

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