Efficient development of a magnetic molecularly imprinted polymer for selective determination of trimethoprim and sulfamethoxazole in milk

Dinali, Laíse Aparecida Fonseca; Oliveira, Hanna Leijoto de; Teixeira, Leila Suleimara; Silva, Anny Talita Maria da; D'Oliveira, Kaique Alexandre; Cuin, Alexandre; Borges, Keyller Bastos

doi:10.1016/j.microc.2020.104648

Cited by 31 publications

(9 citation statements)

References 40 publications

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“…Figure 5 shows the particles after the next modification process, i.e., polymerization aiming to obtain a molecularly imprinted polymer layer on a magnetic core. According to the TEM images ( Figure 5 A,B), after another modification in which the layer of polymer was immobilized on a magnetic particle, it had a more homogeneous distribution than basic Fe 3 O 4 and Fe 3 O 4 @SDS@OA [ 36 ]. Meanwhile, after the removal of the template molecule, MMIPs were characterized by a more visible porous structure with cavities [ 37 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…At 1600–1700 cm −1 a carboxylic bond (C=O) of MAA can be observed. Moreover, the IR of MMIP spectrum also contained bands for C–N at 1300–1150 cm −1 , for C=C at 1350–1550 cm −1 , for C=C=O stretching vibration at 2150 cm −1 , and for C–H stretching vibration at 2900–3050 cm −1 [ 36 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…As can be seen from the results collected in Table 3 , only one text was found, which described the use of a polymer with an imprinted particle with magnetic properties [ 26 ]. In most cases, sample preparation was based on the use of the obtained sorbent in the SPE [ 27 , 29 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ], which requires packing an SPE cartridge. In our opinion, the use of the sorbent in bulk form as a dispersive solid-phase extraction allows a quicker sample preparation.…”

Section: Resultsmentioning

confidence: 99%

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Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk

et al. 2020

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Magnetic molecularly imprinted polymers (MMIPs) are an invaluable asset in the development of many methods in analytical chemistry, particularly sample preparation. Novel adsorbents based on MMIPs are characterized by high selectivity towards a specific analyte due to the presence of a specific cavity on their polymer surface, enabling the lock–key model interactions to occur. In addition, the magnetic core provides superparamagnetic properties that allow rapid separation of the sorbent from the sample solution. Such a combination of imprinted polymers with a magnetic core has an innovative influence on the development of separation techniques. Hence, the present study describes the synthesis of MMIPs with 17β-estradiol used as a template molecule in the production of imprinted polymers. The as-prepared sorbent was used for a sorption/desorption study of five parabens from breast milk samples. The obtained results were characterized by sorption efficiency exceeding 92%, which shows the high affinity of the analytes to the functional groups on the sorbent. The final determination of the selected analytes was done with high-performance liquid chromatography using a fluorometric detector. The determined linearity ranges for selected parabens were characterized by high determination coefficients (r2 from 0.9992 to 0.9999), and the calculated limit of detection (LOD) and limit of quantification (LOQ) for the identified compounds were low (LOD from 1.1–2.7 ng mL−1; LOQ from 3.6–8.1 ng mL−1), which makes their quantitative analysis in real samples feasible.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk

et al. 2020

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“…Fe3O4 nanoparticles were synthesized via co-precipitation [24,25]. FeCl2•4H2O (0.88 g) and FeCl3•6H2O (2.35 g) were dissolved in 40 mL of ultrapure water.…”

Section: Synthesis Of Fe3o4 Nanoparticlesmentioning

confidence: 99%

Synthesis and Characterization of Genistein Magnetic Molecularly Imprinted Polymers and Its Application in Soy Sauce Products

Xie

Luo

et al. 2021

Preprint

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In this study, a novel method based on genistein magnetic molecularly imprinted polymers (Gen-MMIPs) was developed by surface molecular imprinting technique, in which genistein was used as the template molecule and Fe3O4 was used as the carrier. The synthesis of Gen-MMIPs were characterized by using of scanning electron microscopy (SEM) and transmission electron microscopy (TEM), which indicated the diameters of Gen-MMIPs were about 500 nm. Through the technique of vibrating sample magnetometer (VSM), the saturation magnetization of Gen-MMIPs were detected as 24.79 emu/g. Fourier transform infrared (FR-IR) spectroscopy showed that polymer groups were on the surface of the magnetic carrier. Adsorption experiment suggested the adsorption capability of Gen-MMIPs to genistein were 1.55 mg/g, and 2 the adsorption equilibrium was achieved within 20 min. Gen-MMIPs as dispersive solid-phase extraction adsorbent combined with HPLC was used to selectively separate genistein in soy sauce samples, the recoveries were ranged from 85.7% to 88.5% with the relative standard deviations (RSD) less than 5%, which proved this method can be used for the detection of genistein residues in real samples.

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“…In recent years, researchers have discovered a new adsorbent for separation technique which is called magnetic molecularly imprinted polymers (MMIPs). 35 Dinali et al 36 developed a molecularly imprinted polymer for subsequent application in the extraction of trimethoprim and sulfamethoxazole residues in bovine milk. Kaabipour et al 37 synthesized core/shell MMIPs-NPs for extraction and pre-concentration of valsartan from water and urine samples followed by HPLC-UV.…”

Section: Introductionmentioning

confidence: 99%

Magnetic molecularly imprinted polymers for extraction of S‐phenylmercapturic acid from urine samples followed by high‐performance liquid chromatography

Shao

Shi

et al. 2021

J of Molecular Recognition

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In this study, magnetic molecularly imprinted polymers (MMIPs) were prepared and used as sorbents for extraction of S-phenylmercapturic acid (S-PMA) from urine samples, followed by high-performance liquid chromatography ultraviolet-visible (HPLC-UV/Vis) analysis. The MMIPs were synthesized by the copolymerization reaction of (phenylthio) acetic acid (template molecule), methacrylic acid (functional monomers) and ethylene glycol dimethacrylate (cross-linkers). The morphology, structure property and surface groups of the prepared MMIPs were characterized by scan electron microscopy, transmission electron microscopy, infrared spectroscopy, X-ray diffraction pattern, thermogravimetric analyses, Brunauer-Emmett-Teller and vibrating sample magnetometer. The selectivity of the MMIPs was investigated in the presence of interferents. Various parameters affecting the S-PMA extraction efficiency were investigated, including MMIPs amount, pH, sample volume, desorption solvent, as well as extraction and desorption time. The obtained optimal parameters were as follows: MMIPs amount (20 mg), pH (3.0), sample volume (5 mL), desorption solvent (methanol/acetic acid [9/1, v/v]), extraction time (30 minutes) and desorption time (2 minutes). The method was validated according to the Food and Drug Administration Guidance for Industry on Bioanalytical Method Validation. The calibration curve for the analyte was linear in the concentration range of 0.030-1.0 mg/L (r = 0.9995).The LOD and LOQ of the method were 0.0080 and 0.0267 mg/L, respectively. The enrichment factor of the MMIPs was 5. The relative standard deviations of intra-and inter-day tests were in the range of 3.8-5.1% and 3.9-6.3%, respectively. The recoveries at three different concentrations of 0.10, 0.50 and 0.80 mg/L ranged between 95.2% and 98.6%. In addition, the MMIPs could be reused for at least eight times.The proposed method was successfully applied to the determination of S-PMA in urine samples. In addition, this developed method could be used as a tool in the early screening and clinical diagnosis of benzene intoxication.

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Efficient development of a magnetic molecularly imprinted polymer for selective determination of trimethoprim and sulfamethoxazole in milk

Cited by 31 publications

References 40 publications

Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk

Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk

Synthesis and Characterization of Genistein Magnetic Molecularly Imprinted Polymers and Its Application in Soy Sauce Products

Magnetic molecularly imprinted polymers for extraction of S‐phenylmercapturic acid from urine samples followed by high‐performance liquid chromatography

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