Efficacy, safety and quality of life of calcipotriol/betamethasone dipropionate (Dovobet^®) versus calcipotriol (Daivonex^®) in the treatment of psoriasis vulgaris: A randomized, multicentre, clinical trial

Abstract

Our results demonstrate a higher efficacy and more rapid onset of action with the two-compound ointment compared with calcipotriol cream alone in short-term treatment. However, sequential application of calcipotriol allows maintenance of the results.

Efficacy and maintenance strategies of two-compound formulation calcipotriol and betamethasone dipropionate gel (Xamiol® gel) in the treatment of scalp psoriasis: results from a study in 885 patients

“…The efficacy and safety of the combination of calcipotriol 50 mg/g, betamethasone dipropionate 0.5 mg/g, have been shown in previous studies (7)(8)(9)(10)(11)(12)(13)(14). The once-daily application of this combination in clinical studies on scalp psoriasis proved to be significantly superior to the individual components calcipotriol and betamethasone with respect to rapidity of effects and efficacy (10)(11)(12)(13).…”

“…This is a lipophilic gel formulation, particularly suitable for application to the scalp that combines the keratinocytes differentiation action of the vitamin D 3 analogues with the anti-inflammatory effect of steroids reducing the side-effect profile of the single topical agent. Previous studies showed the efficacy and safety of this combination in mild-to-moderate plaque-type psoriasis of body and scalp (7)(8)(9)(10)(11)(12)(13)(14). However, maintenance strategies after complete remission have been poorly investigated.…”

Calcipotriol plus Betamethasone Dipropionate Gel Compared with Tacalcitol Ointment and the Gel Vehicle Alone in Patients with Psoriasis Vulgaris: A Randomized, Controlled Clinical Trial

“…There is an ongoing need for the development of new formulations and therapeutic regimens suitable for the treatment of psoriasis. Previous reports have emphasized the high efficacy of treatments combining vitamin D analogues and corticosteroids [16]. Use of calcipotriol/betamethasone dipropionate ointment (Daivobet/Dovobet/Taclonex) in the treatment of psoriasis vulgaris is well documented [8,9,10,11,12,13,17,18].…”

Once-daily topical treatment for psoriasis: calcipotriene + betamethasone two-compound topical formulation

“…This combination increases the efficacy of treatment for psoriasis vulgaris, although one clinical trial showed that it may not be as effective as clobetasol, which is a superpotent class I topical steroid 3,4,16,17. The probability of a ≥75% reduction in PASI has been reported to be 47%–50% with once-daily calcipotriene + betamethasone ointment 5,18.…”