Efficacy and maintenance strategies of two-compound formulation calcipotriol and betamethasone dipropionate gel (Xamiol® gel) in the treatment of scalp psoriasis: results from a study in 885 patients

Saraceno, Rosita; Camplone, G.; D’agostino, M. A.; Simone, Clara De; Cesare, Antonella Di; Filosa, Giorgio; Frascione, Pasquale; Gabellini, Massimo; Lunghi, Franco; Mazzotta, Annamaria; Peris, Ketty; Luzio, Genoveffa Scotto Di; Calvieri, Stefano; Simonacci, Marco; Chimenti, Sergio

doi:10.3109/09546634.2013.800182

Cited by 34 publications

(28 citation statements)

References 16 publications

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“…Another 12‐week study on scalp psoriasis compared the classical „on demand“ regimen of the two compound gel with a regimen to be used twice a week. A significantly higher percentage of remissions was achieved with the twice‐weekly regimen (p < 0.05) compared to the „on demand“ regimen . ▸ Standardized, simple treatment regimens seem to achieve better therapeutic results than on‐demand regimens.…”

Section: Discussionmentioning

confidence: 98%

“…Another 12-week study on scalp psoriasis compared the classical "on demand" regimen of the two compound gel with a regimen to be used twice a week. A significantly higher percentage of remissions was achieved with the twiceweekly regimen (p < 0.05) compared to the "on demand" regimen [42]. Neither data are available to compare different treatment modalities (re-induction therapy, on demand regimens) regarding their efficacy, safety and adherence for therapeutic intervals >12 weeks, nor to determine the optimum time point to switch from a daily treatment to a once-to twice weekly maintenance therapy.…”

Section: Evaluation Of Treatment Regimensmentioning

confidence: 99%

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Topical long‐term therapy of psoriasis with vitamin D₃ analogues, corticosteroids and their two compound formulations: position paper on evidence and use in daily practice

Augustin

Mrowietz²,

Bonnekoh

et al. 2014

J Deutsche Derma Gesell

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SummaryBackground: Current data from daily practice show that vitamin D 3 analogues, corticosteroids and their fixed combination products are used heterogeneously for topical long-term treatment of psoriasis.Aim: To evaluate scientific evidence about topical long-term therapy with vitamin D 3 analogues, corticosteroids and their two-compound-products in psoriasis vulgaris and scalp psoriasis and to develop daily practice recommendations. Methods: Systematic literature review via PubMed® and Embase® and informal expert consensus.Results: The search strategy identified 21 relevant clinical trials. Best evidence regarding topical long term treatment was available for the two-compound-formulation containing calcipotriene and betamethasone. In a comparative trial in psoriasis vulgaris the two-compound-formulation showed superior tolerability and cost effectiveness compared to monotherapy. In scalp psoriasis the two-compound-gel was superior compared to calcipotriene monotherapy. Standardized and simplified treatment application modes resulted in a better clinical outcome comparing to on-demand therapies.Daily practice recommendations: Patients should be proactively involved in the choice of treatment, formulation and mode of application. Besides long-term treatment with the two-compound-formulation other treatment regimens including calcipotriene monotherapy can also be considered. Due to a favorable risk-benefit ratio in maintenance trials and due to better cost-effectiveness the application of two-compound-products once or twice a week after initial therapy is recommended.

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Section: Discussionmentioning

confidence: 98%

Section: Evaluation Of Treatment Regimensmentioning

confidence: 99%

Topical long‐term therapy of psoriasis with vitamin D₃ analogues, corticosteroids and their two compound formulations: position paper on evidence and use in daily practice

Augustin

Mrowietz²,

Bonnekoh

et al. 2014

J Deutsche Derma Gesell

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“…Compared to ''on-demand'' treatment with calcipotriol/betamethasone dipropionate gel a structured twice-weekly applications of this two compound product was more effective and associated with a lower rate of relapse in a comparative real practice study (28). Considering a group of psoriatic patients, an intermittent schedule of the two compound products twice weekly was a better maintenance treatment as compared to an on demand schedule.…”

Section: Maintenance Phasementioning

confidence: 96%

“Patient-centered treatment” for mild-to-moderate psoriasis

Koetsier

Kerkhof

2015

Journal of Dermatological Treatment

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People with mild-to-moderate psoriasis have an impaired healthrelated quality of life. Surprisingly, on one hand, at least one-third of these patients are not seeing a physician during episodes of at least 1 year on and average. On the other hand, some patients are seen by the GP and simultaneously by several dermatologists. In this review, we will try to understand this discrepancy between unmet need and medical consumption by reviewing evidencebased data on topical treatments as well as patient reported outcomes and aspects of adherence.In a recent study in patients treated by general practitioners (GPs) in the United Kingdom, awareness of psoriasis, diagnosis, and the options for treatments were low for GPs and their patients. Indeed, it is also our impression that continuous long-term control of mild-to-moderate psoriasis by the GP's is not adequate in all patients, which they have referred to us. In particular, the limitations of chronic exposure to (super)potent corticosteroids, treatment adherence, and the expectations of the patients have to be reconciled in this respect. In order to provide a high-quality management of patients with mild-to-moderate psoriasis, a ''patient centered approach'' is proposed. This model is based on the following considerations:(1) The step-wise approach in treatment selection.(2) Monitoring adherence factors and patient reported outcome measures in a virtual environment. (3) A virtual treatment environment and a liaison between echelons of care. The present review provides the rationale and propositions for a tentative program using ICT solutions and face-to-face contacts for a patient centered treatment model. Ultimately we will suggest the ''patient-centered approach'', a combination of a virtual treatment environment and faceto-face consultations to improve quality and cost effectiveness of care for patients with mild-to-moderate psoriasis.

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“…Eine ebenfalls zwölfwöchige Studie bei Kopfhaut‐Psoriasis verglich direkt das klassische „Nach‐Bedarf‐Anwendungsschema“ der Fixkombination in Gelform mit einem Erhaltungstherapieschema, das die Anwendung der Fixkombination auf zweimal pro Woche festlegte. Dabei zeigte die zweimal pro Woche verabreichte Fixkombinationstherapie einen signifikant (p < 0,05) höheren Anteil an Remissionen als eine „nach Bedarf“ angewendete Fixkombinationstherapie . ▸Feste, einfache Therapieschemata scheinen einen höheren Therapieerfolg zu erzielen als „Nach‐Bedarf‐Therapien“.…”

Section: Diskussionunclassified

Topische Langzeittherapie der Psoriasis mit Vitamin‐D₃‐Analoga, Kortikosteroiden und deren Kombinationen: Positionspapier zu Evidenz und praktischer Anwendung

Augustin

Mrowietz

Bonnekoh

et al. 2014

J Deutsche Derma Gesell

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ZusammenfassungHintergrund: Aktuelle Daten aus der Versorgungsforschung zeigen, dass Vitamin-D 3 -Analoga, Kortikosteroide und deren fixe Kombinationen in der topischen Langzeittherapie der Psoriasis sehr unterschiedlich eingesetzt werden. Praxisempfehlungen: Patienten müssen aktiv in die Wahl der Therapie, der Grundlage und der Anwendungsweise einbezogen werden. In der Praxis haben sich neben der Langzeittherapie mit der Fixkombination auch andere Therapieschemata unter Einbeziehung der Calcipotriol-Monotherapie bewährt. Aufgrund des guten Nutzen-Risiko-Profils in Studien zur Erhaltungstherapie und aufgrund der höheren Wirtschaftlichkeit ist im Anschluss an die Initialtherapie eine 1-bis 2-mal wöchentliche Applikation der Fixkombination zu empfehlen. Zielsetzung SummaryBackground: Current data from daily practice show that vitamin D 3 analogues, corticosteroids and their fixed combination products are used heterogeneously for topical long-term treatment of psoriasis.

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Efficacy and maintenance strategies of two-compound formulation calcipotriol and betamethasone dipropionate gel (Xamiol® gel) in the treatment of scalp psoriasis: results from a study in 885 patients

Abstract: The maintenance of twice-weekly application versus on-demand treatment of calcipotriol/betamethasone dipropionate gel is more effective and is associated with a lower rate of relapse.

Cited by 34 publications

References 16 publications

Topical long‐term therapy of psoriasis with vitamin D₃ analogues, corticosteroids and their two compound formulations: position paper on evidence and use in daily practice

Topical long‐term therapy of psoriasis with vitamin D₃ analogues, corticosteroids and their two compound formulations: position paper on evidence and use in daily practice

“Patient-centered treatment” for mild-to-moderate psoriasis

Topische Langzeittherapie der Psoriasis mit Vitamin‐D₃‐Analoga, Kortikosteroiden und deren Kombinationen: Positionspapier zu Evidenz und praktischer Anwendung

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Efficacy and maintenance strategies of two-compound formulation calcipotriol and betamethasone dipropionate gel (Xamiol® gel) in the treatment of scalp psoriasis: results from a study in 885 patients

Abstract: The maintenance of twice-weekly application versus on-demand treatment of calcipotriol/betamethasone dipropionate gel is more effective and is associated with a lower rate of relapse.

Cited by 34 publications

References 16 publications

Topical long‐term therapy of psoriasis with vitamin D3 analogues, corticosteroids and their two compound formulations: position paper on evidence and use in daily practice

Topical long‐term therapy of psoriasis with vitamin D3 analogues, corticosteroids and their two compound formulations: position paper on evidence and use in daily practice

“Patient-centered treatment” for mild-to-moderate psoriasis

Topische Langzeittherapie der Psoriasis mit Vitamin‐D3‐Analoga, Kortikosteroiden und deren Kombinationen: Positionspapier zu Evidenz und praktischer Anwendung

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Product

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About

Topical long‐term therapy of psoriasis with vitamin D₃ analogues, corticosteroids and their two compound formulations: position paper on evidence and use in daily practice

Topical long‐term therapy of psoriasis with vitamin D₃ analogues, corticosteroids and their two compound formulations: position paper on evidence and use in daily practice

Topische Langzeittherapie der Psoriasis mit Vitamin‐D₃‐Analoga, Kortikosteroiden und deren Kombinationen: Positionspapier zu Evidenz und praktischer Anwendung