Efficacy of Thermotherapy to Treat Cutaneous Leishmaniasis Caused byLeishmania tropicain Kabul, Afghanistan: A Randomized, Controlled Trial

Abstract

Thermotherapy is an effective, comparatively well-tolerated, and rapid treatment for CL, and it should be considered as an alternative to antimony treatment.

Thermoterapy effective and safer than miltefosine in the treatment of cutaneous leishmaniasis in Colombia

“…This result was comparable to that obtained in Kabul, Afghanistan, where the efficacy by protocol was found to be 69.4% 19 and less than that found in other studies where localized heat was applied in various dosages.…”

“…The Thermomed ® is an operator, with special devices which achieve and maintain a temperature of 50 ºC. The electrodes are placed locally in the lesion for 30 seconds, the device produces heat waves through radio frequency technology, which extends them to deeper layers of the skin, causing destruction of the amastigotes 10,11,16,19,30 . In Colombia, there has only been one report of the use of thermotherapy in the treatment of CL in a study that focused on patients with an L. guyanensis from the Andean region; however, the elevated number of participant follow-up losses (81%) decreased the power of the study and did not allow for a conclusive efficacy result 29 .…”

Clinical and Epidemiologic Profile of Cutaneous Leishmaniasis in Colombian Children: Considerations for Local Treatment

“…Thermotherapy has proven efficacious in the treatment of CL in adults in Old and New World settings, with cure rates from 58% to 75% for CL caused by L. braziliensis or L. panamensis and from 69% to 73% for L. tropica and L. major. [26][27][28][29][30] Tolerability of thermotherapy for young children, who can require multiple treatments to achieve clinical resolution, has not been evaluated. A recent study of intralesional treatment of CL in patients 12 years of age and older in Bolivia reported 70% efficacy and was considered an attractive therapeutic alternative for approximately 49% of patients having infections attributable to L. braziliensis who met the criteria of single lesions of less than 900 mm 2 .…”

Technological Development in Therapeutic Applications of Alternating Electric Fields: Review

“…However, the extensive use of antibiotics holds a threat in the future due to the rapid rise of multi drug resistant bacteria. Recently, a number of alternative modes like weak electric currents [1,2,3,4], ultrasound wave therapy [5,6,7] , thermotherapy [8], photodynamic therapy [9] have been studied. These are expected to aid the antibiotics in the battle against bacterial pathogens.…”