We develop a model of single spherical cell electroporation and simulate spatial and temporal aspects of the transmembrane potential and pore radii as an effect of any form of applied electric field. The extent of electroporation in response to sinusoidal electric pulses of two different frequencies in a range of extracellular conductivity for two different cell radii are compared. Results show that pore radii tend to be more normalized for AC fields. The relative difference in fractional pore area is reduced by the use of a 1MHz sinusoidal applied electric field over a 100kHz field.
We investigated the stability of light transmission through Intralipid-based optical phantoms in the wavelength range of 400-950 nm at temperatures between 35 and 70 °C. Optical phantoms are materials commonly used to simulate the light scattering and absorption properties of biological materials. These simulations require the phantom to be optically stable. We demonstrate that the scattering properties of Intralipid remain stable at higher temperatures, varying less than 0.5%. We also present results that show this is not the case for absorption below 700 nm at 35 and 70 °C, with greater instability at 70 °C. For example, at 500 nm, the light intensity transmitted through 15 mm of Intralipid dropped 39% over 12 h. We demonstrate that oxidation of fatty acids in Intralipid could account for this effect and show, by flushing the system continuously with nitrogen gas, the instability is reduced.
Their combination of large continuous energy ratings and very large time constants allows supercapacitors to be used in surge protection circuits. This fact, supported by recent research publications and laboratory tests, has assisted the authors to propose a new surge protection circuit topology known as the supercapacitor-assisted surge absorber (SCASA). This technique utilizes a multi-winding transformer, common surge protector devices such as metal oxide varistors (MOV) and/or semiconductor types combined with a supercapacitor sub-circuit to absorb part of the surge energy usually expected to dissipate within the MOV or the semiconductor. The paper presents design details and test results for a differential mode surge protector based on the SCASA technique where the test device was subjected to lightning-type surges defined in international standards for Class-A and Class B type protectors. The performance of a prototype based on Class-B waveforms of up to 6.6 kV surges generated from a lightning surge simulator are discussed in the paper. Its performance is compared with two commercially available surge protectors.
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