Efficacy of the self-assembling peptide P11-4 in constructing a remineralization scaffold on artificially-induced enamel lesions on smooth surfaces

Remineralization of Early Carious Lesions using Biomimetic Selfassembling Peptides Versus Fluoride agent. (In vitro and In vivo study)

“…The visual and clinical results of the Curodont in the present study was in accordance also to a study (26 that showed better visual and microscopic changes in Curodont group than in control group.…”

“…The results of Curodont group, agreed with the results of another study (26) showed that with Curodont it was possible to achieve visual and microscopic changes in artificially created enamel lesions stored in a remineralizing medium. Moreover, the results of the Ra of the present study came in accordance with a study that found significant reduction in enamel roughness values on comparing eroded enamel and eroded enamel treated with Curodont (25) .…”

Ultrasonic assessment of the effects of self-assembling peptide scaffolds on preventing enamel demineralization

“…The results of the present study were consistent with those of previous reports. CDR has an ability to form scaffold-like structures with negatively charged domains, which control initial mineral deposition and subsequent hydroxyapatite crystal growth [21]. Therefore, the presence of CDR might permit a rapid return to resting mineral concentrations and allow the immediate remineralization of the Figure 2.…”

Effects of Self-Assembling Peptide P11-4, Fluorides, and Caries Infiltration on Artificial Enamel Caries Lesions in vitro

“…Due to the similar RI of the infiltrant (1.52) compared with apatite, light scattering is reduced and visual color differences to enamel are decreased directly after application. P11-4 is presumed to mask initial lesions by reversing the caries lesions under (ideal) remineralizing conditions [Jablonski-Momeni and Heinzel-Gutenbrunner, 2014]. However, data from controlled clinical studies are inconclusive [Brunton et al, 2013].…”

“…In vitro, a significant increase in the subsurface microhardness could be observed after the application of Curodont TM Repair [Schmidlin et al, 2016]. Furthermore, after the application of Curodont TM Repair significantly improved quantitative light-induced fluorescence values could be observed in another in vitro study, but only when 2 control groups were merged in the analysis [Jablonski-Momeni and Heinzel-Gutenbrunner, 2014]. Nonetheless, in both in vitro studies enamel specimens were solely stored in remineralizing solutions for 4 or 12 weeks, respectively.…”