Remineralization of Early Carious Lesions using Biomimetic Selfassembling Peptides Versus Fluoride agent. (In vitro and In vivo study)

Metwally, Noha; Niazy, Maha A.; El-Malt, Magda

doi:10.21608/adjg.2017.5226

Cited by 15 publications

(13 citation statements)

References 19 publications

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“…As there are tragically few therapeutic agents for dental caries, it is exciting that there are ten clinical trials demonstrating an anti-caries effect by CR. 33–36,39,40,44,49–51 Clinical trials supporting other brush-on treatments for caries include those of traditional fluorides, sealants (including resin-infiltration), and SDF (including silver nitrate and fluoride varnish). 18,52 This is perilously insufficient, considering that caries is the most common disease in humans.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review and Meta-Analysis on the Effect of Self-Assembling Peptide P₁₁-4 on Initial Caries Lesions

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Skaret²,

Thakkar‐Samtani

et al. 2022

Preprint

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Background: Dental caries remains a global problem that causes disproportionate suffering in underserved populations. Simple interventions are needed to improve patient experience, clinical and cost-effectiveness, and access to care. The self-assembling peptide P11-4 is a recently developed, non-invasive treatment that regenerates enamel in initial caries lesions. Studies reviewed: We conducted a systematic review and meta-analysis on the effectiveness of the P11-4 products CurodontTM Repair (CR) and CurodontTM Repair Fluoride Plus (CRFP) on initial caries lesions. Primary outcomes were lesion progression after 24 months, caries arrest, and cavitation. Secondary outcomes were changes in merged International Caries Detection and Assessment System (ICDAS) score, Quantitative Light Fluorescence, esthetic appearance, and lesion size. Results: Six clinical trials comparing CR to controls met the inclusion criteria. Results of this review represent two primary and two secondary outcomes. When compared to parallel groups, CR improved caries arrest (RR: 1.82; 95% CI: 1.32 to 2.50; 45% attributable risk; 95% CI: 24 to 60%) and decreased lesion size by 32% (Hedge g: -0.59; CI: -1.03 to -0.15). We observed positive trends for avoiding cavitation (RR: 0.32; CI: 0.10 to 1.06) and lowering merged ICDAS score (RR: 3.68; CI: 0.42 to 32.3). No studies used CRFP or reported adverse esthetic changes. Practical implications: CR has a treatment effect on caries arrest and decreased lesion size. Two trials contributing to the caries arrest result had non-masked assessors, and all trials had elevated risks of bias. We recommend conducting longer trials. CR is a promising treatment for initial caries lesions.

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Section: Discussionmentioning

confidence: 99%

Systematic Review and Meta-Analysis on the Effect of Self-Assembling Peptide P₁₁-4 on Initial Caries Lesions

Keeper

Skaret²,

Thakkar‐Samtani

et al. 2022

Preprint

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“…Mapping of the mechanical properties for natural WSLs supplemented by SEM observations was conducted by Huang et al in [ 22 ]. Metwally et al used in vivo radiographic tracing of structure to show the stages of the remineralization process for young permanent teeth with WSLs in [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Enamel and Dentine about a White Spot Lesion: Mechanical Properties, Mineral Density, Microstructure and Molecular Composition

et al. 2020

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The study focuses on in vitro tracing of some fundamental changes that emerge in teeth at the initial stage of caries development using multiple approaches. The research was conducted on a mostly sound maxillary molar tooth but with a clearly visible natural proximal white spot lesion (WSL). Values of mineral density, reduced Young’s modulus, indentation hardness and creep as well as the molecular composition and surface microstructure of the WSL and bordering dentine area were studied. The results obtained were compared to those of sound enamel and dentine on the same tooth. A decrease of mechanical properties and mineral density both for the WSL and bordering dentine was detected in comparison to the sound counterparts, as well as increase of creep for the enamel WSL. Differences in molecular composition and surface microstructure (including the indenter impressions) were found and described. WSL induces a serious change in the state of not only the visually affected enamel but also surrounding visually intact enamel and dentine in its vicinity. The results provide the basis for future studies of efficacy of minimal invasive treatments of caries.

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“…The required time for completing the treatment was calculated with stop watch chronometer by an assistant. The stop watch was clicked after application of the Optra gate system (13) . Results were calculated, tabulated and statistically analyzed.…”

Section: Radiographic Parameter (1)mentioning

confidence: 99%

Assessment the Efficacy of Resin Infiltration in Treatment of Young Permanent Teeth

2021

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Purpose: To evaluate the efficacy of resin infiltration in treatment of young permanent teeth and to evaluate dental anxiety related to resin infiltration procedure and the time required. Material and methods: 22 Egyptian children ranging from 6-14 years of age were selected with at least 2 smooth surface white lesions (WSL), one on each side using split mouth design. Lesions were assigned in a random way into 2 groups; Group I, Group II. Group I: resin infiltration, Group II: fluoride varnish.Radiographic and Photographic records were taken before treatment, immediately after treatment and 12 months plus assessing the marginal adaptation and discoloration. A facial image scale (FIS) was recorded. The outcome data were recorded, tabulated, coded to be statistically analyzed. Results: by radiographic evaluation immediately after treatment and through the study period the difference was statistically significant in the mean of DSR and RD between groups in favor of group I. By the descriptive analysis the difference of mean of change in both marginal adaptation and discoloration was not a statistically significant. While group I, show increase in mean of marginal adaptation but did not reach to significance level. But within group II, the mean of discoloration has shown statistically significantly difference. Dental anxiety was low in both groups with no statistically significantly difference. Conclusion: Infiltration concept was bridging the gap between "wait and see"; it is a promising micro-invasive approach.

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Remineralization of Early Carious Lesions using Biomimetic Selfassembling Peptides Versus Fluoride agent. (In vitro and In vivo study)

Abstract: Objective: The purpose of this study is to evaluate the remineralization potential of the self-assembling peptideP11-4 (Curodont repair) versus highly concentrated fluo-

Cited by 15 publications

References 19 publications

Systematic Review and Meta-Analysis on the Effect of Self-Assembling Peptide P₁₁-4 on Initial Caries Lesions

Systematic Review and Meta-Analysis on the Effect of Self-Assembling Peptide P₁₁-4 on Initial Caries Lesions

Characterization of Enamel and Dentine about a White Spot Lesion: Mechanical Properties, Mineral Density, Microstructure and Molecular Composition

Assessment the Efficacy of Resin Infiltration in Treatment of Young Permanent Teeth

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Remineralization of Early Carious Lesions using Biomimetic Selfassembling Peptides Versus Fluoride agent. (In vitro and In vivo study)

Abstract: Objective: The purpose of this study is to evaluate the remineralization potential of the self-assembling peptideP11-4 (Curodont repair) versus highly concentrated fluo-

Cited by 15 publications

References 19 publications

Systematic Review and Meta-Analysis on the Effect of Self-Assembling Peptide P11-4 on Initial Caries Lesions

Systematic Review and Meta-Analysis on the Effect of Self-Assembling Peptide P11-4 on Initial Caries Lesions

Characterization of Enamel and Dentine about a White Spot Lesion: Mechanical Properties, Mineral Density, Microstructure and Molecular Composition

Assessment the Efficacy of Resin Infiltration in Treatment of Young Permanent Teeth

Contact Info

Product

Resources

About

Systematic Review and Meta-Analysis on the Effect of Self-Assembling Peptide P₁₁-4 on Initial Caries Lesions

Systematic Review and Meta-Analysis on the Effect of Self-Assembling Peptide P₁₁-4 on Initial Caries Lesions