Efficacy of the intralesional treatment with Chenopodium ambrosioides in the murine infection by Leishmania amazonensis

Patrício, Fernando J.; Costa, Graciomar C.; Pereira, Pedro Paulo; Aragão-Filho, Walmir Cutrim; Sousa, Sanara M.; Frazão, Josias Brito; Pereira, Wanderson S.; Maciel, Márcia C.G.; Silva, Lucilene A.; Amaral, Flávia Maria Mendonça do; Rebêlo, José Manuel Macário; Guerra, Rosane Nassar Meireles; Ribeiro, Maria Nilce de Sousa; Nascimento, Flávia R.F.

doi:10.1016/j.jep.2007.10.009

Cited by 47 publications

(37 citation statements)

References 32 publications

(38 reference statements)

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“…Fatty acids like oleic, linoleic, palmitic, stearic, cis-11-eicosenoic and cis-11,14-eicosadienoic were found in this species (Martinez-Herrera et al, 2006). Fabaceae, the family of legumes, covers 650 genera and 18,000 species (Pietrobom & Oliveira, 2004). The medicinal plants of this family found in this study were Copaifera langsdorffii Desf., Hymenaea courbaril L., Bauhinia forficata Link subsp.…”

Section: Discussionmentioning

confidence: 49%

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Medicinal plants used in Rondônia, Western Amazon, Brazil

Santos

Lima

Oliveira

2014

Rev. bras. plantas med.

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ABSTRACT:This study refers to the use of medicinal plants by populations in the Western Amazon and provides information that can be used in phytochemical studies. It draws upon the traditional knowledge regarding the use of medicinal plants in five regions of the state of Rondônia, in the Brazilian Amazon, focusing on native species. The field research was carried out in five municipalities of the state of Rondônia: Ariquemes, Buritis, Candeias do Jamari, Cujubim and Itapoa do Oeste, characterized by primary economic sectors: agriculture, cattle farming, plant extraction and mineral exploration. Structured interviews were applied to 227 persons chosen because of their prestige in the communities in relation to the knowledge and use of medicinal plants, identifying the therapeutic purpose, parts of the plant used and methods of preparation. The species were taxonomically identified. The ethnobotanic knowledge (inferred by the number of uses of medicinal plants per person) was correlated with the Brazilian region of origin, age, and gender of the interviewees. According to the collected data, 34 botanical families and 53 native species were identified. Of the 53 species, only 7 occur exclusively in the Amazon Forest: Theobroma grandiflorum (Willd. ex Spreng.) K. Schum., Psidium densicomum Mart. ex DC, Piper cavalcantei Yunck., Pilocarpus microphyllus Stapf ex Wardlew., Euterpe oleracea Mart., Croton cajucara Benth., Baccharis altimontana G. Heiden. The most common disorders treated with the plants were kidney problems, influenza, generalized infections and inflammations, malaria and high blood pressure. Leaves were the most used parts in preparations. Barks, fruits, roots, flowers, stems, seeds, oils, buds, tubercles, and rhizomes were also mentioned. Thirteen forms of preparations were recorded, and infusion and decoction were the most used. Syrups, juices, flour, sap, oil and parts of the plant blended with milk, honey and coffee or flamed, macerated and in the form of poultice, were also found. Persons from the Southeast region had more information compared with persons from the other regions; persons in the age groups between 50-59, 60-69 and 70-79 had more information in comparison with the other age groups; and the female interviewees mentioned significantly more uses of medicinal plants than the male ones. The relatively small number of native Amazon species identified can be the result of the loss of knowledge about medicinal plants in the Amazon because of internal migration, extinction of local indigenous groups, increasing urbanization and consequent globalization of the lifestyles. Keywords: Ethnobotany, Phytotherapy, Traditional Medicine.RESUMO: Plantas medicinais usadas em Rondônia, Amazônia Ocidental, Brasil. Este estudo se refere ao uso de plantas medicinais por populações da Amazônia Ocidental, fornece informações passíveis de utilização em estudos fitoquímicos e resgata o conhecimento tradicional a respeito do uso de plantas medicinais em cinco regiões do estado de Rondônia na Amazônia Brasileira...

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Section: Discussionmentioning

confidence: 49%

“…ambrosioides has antitumor activity (Cruz et al, 2007) and is used to treat ulcers caused by Leishmania (Patrício et al, 2008). It has flavonol glycosides, kaempferol 3-ramnoside-4'-xyloside and kaempferol xyloside 3-ramnoside-7, along with isoramnetin kaempferol and quercetin (Jain et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

Medicinal plants used in Rondônia, Western Amazon, Brazil

Santos

Lima

Oliveira

2014

Rev. bras. plantas med.

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“…This fact was verified by the presence of amastigotes forms of L. braziliensis and the cellular infiltrate in footpad, and an increase of drainage lymph nodes. On the other hand, the oral treatments with Kalanchoe pinnata (Da Silva et al, 1999), Chenopodium ambrosioides (Patrício et al, 2008), Tinospora sinensis (Singh et al, 2008) were able to control the dissemination of Leishmania sp. infection.…”

Section: Discussionmentioning

confidence: 99%

Effect of ethyl acetate extract from husk fiber water of Cocos nucifera in Leishmania braziliensis infected hamsters

Freitas¹,

Nunes-Pinheiro²,

Pessoa³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The objective of this study was to evaluate the treatment with ethyl acetate extract (EAE) from husk fiber water of Cocos nucifera L., Arecaceae, in L. braziliensis (Lb) infected hamsters. Twelve male hamsters were randomly allocated in three groups (n=4): G1 received only EAE; G2 was infected with Lb only and G3 received EAE after Lb infection. The infection was carried 28 days prior to the treatment with EAE, which was administrated (0.2 mL, 300 mg.kg -1 ) for 21 consecutive days. Infection was evaluated through skin lesions and infected footpad edema. Haematological evaluation was done on -28 th , 0 and 21 st days. Imprint footpad and lymph node weight were evaluated on 21 st day. Lb infection significantly inhibited the peripheral leukocytes blood. However, neutrophils and lymphocytes values did not have significant alterations. G3 presented eosinophilia in relation to G2. The treatment with EAE did not reduce edema of infected footpad neither weight of drainage lymph node. Infected footpad imprints revealed amastigotes forms and cellular infiltration. Animals from G3 presented skin lesions on 7 th day, shown a reduction of these lesions in day 14. Therefore, the treatment with EAE did not alter the etiological agent elimination in these conditions. However, EAE presents a healing activity in this experimental model.

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“…Possuem ainda como princípios ativos os glicosídios cianogenéticos, saponina (PROJETO GUANDU, 1995), cineol, cimeno, salicilato de metila, quenopodina, histamina, limaneno, glicol, ácidos butírico e salicílico (ALBUQUERQUE, 1989). Estudos indicam ação inseticida (DELOBEL e MALONGA, 1987), repelente (MAZZONETTO, 2002), ação antifúngica (JARDIM, 2008) e o uso tópico das folhas são eficazes no tratamento de Leishmaniose cutânea (PATRÍCIO et al 2008). …”

Section: Introductionunclassified

Análise hematológica e bioquímica da bioatividade da erva-de-santa-maria em bovinos

Pozzatti¹,

Porfírio²,

Casagrande³

et al. 2011

Pubvet

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A erva-de-santa-maria (Chenopodium ambrosioides L.) é uma das plantas usadas na fitoterapia humana, tendo sua origem na América tropical e subtropical, Antilhas e México, sendo muito abundante no Brasil. O Rhiphicephalus (Boophilus) microplus é conhecido no Brasil como carrapato dos bovinos, sendo parasita de alta importância, produzindo perdas diretas e indiretas pela transmissão de doenças e alto custo de seu combate. Este trabalho avaliou os resultados da erva-de-santa-maria sobre os carrapatos,

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Efficacy of the intralesional treatment with Chenopodium ambrosioides in the murine infection by Leishmania amazonensis

Cited by 47 publications

References 32 publications

Medicinal plants used in Rondônia, Western Amazon, Brazil

Medicinal plants used in Rondônia, Western Amazon, Brazil

Effect of ethyl acetate extract from husk fiber water of Cocos nucifera in Leishmania braziliensis infected hamsters

Análise hematológica e bioquímica da bioatividade da erva-de-santa-maria em bovinos

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