Efficacy of six days triple therapy with pantoprazole plus clarithromycin and amoxycillin versus omeprazole plus clarithromycin and amoxycillin for H. pylori eradication

Domínguez-Martín, Antonio; Domínguez-Muñoz, Antonio; Muñoz, Santiago J.; Alonso, J. Blasco; González, Miguel

doi:10.1016/s0016-5085(98)80435-6

Cited by 5 publications

(9 citation statements)

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“…These clinically equivalent findings are well in accordance with results of other trials combining a proton pump inhibitor either with clarithromycin and metronidazole or clarithromycin and amoxycillin 4 , . 6 In other trials using a combination therapy of pantoprazole and two antibiotics, high eradication rates could also be demonstrated 7 –13 …”

Section: Discussionmentioning

confidence: 99%

“…Clinical trials combining the proton pump inhibitor pantoprazole with clarithromycin and metronidazole have shown promising results in the eradication of H. pylori 7 –10 . A triple therapy comprising pantoprazole, clarithromycin and either amoxycillin or metronidazole was also demonstrated to be well‐tolerated and effective in the eradication of the bacterium 11 –13 . However, comparable data of a direct comparison in a large population are missing.…”

Section: Introductionmentioning

confidence: 99%

“…Patients were administered pantoprazole with either clarithromycin and metronidazole (PCM) or clarithromycin and amoxycillin (PAC) for 1 week, followed by a 7-day pantoprazole therapy. The primary criterion of this study was the H. pylori eradication rate determined by 13 C-urea breath test. Pain alleviation, reduction of gastrointestinal symptoms and tolerability were considered as secondary criteria.…”

Section: Introductionmentioning

confidence: 99%

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Eradication of Helicobacter pylori with pantoprazole and two antibiotics: a comparison of two short‐term regimens

Frevel¹,

Daake²,

Janisch³

et al. 2000

Aliment Pharmacol Ther

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Since the discovery of Helicobacter pylori in the early 1980s, its role as a major pathogenic factor in peptic ulcer disease has been well established. Therapeutic regimens aiming to eradicate the bacterium have been shown to be highly effective and are strongly recommended in the treatment of patients with peptic ulcer disease.1 With classic bismuth salt based triple therapy, combining bismuth with two antibiotics, poor compliance is often observed resulting from a high incidence of side-effects. 2 In search for therapeutic approaches leading to fewer side-effects and compliance problems, regimens combining antibiotics with proton pump inhibitors have been under investigation. The latter are not only used to relieve symptoms but also to provide an optimal environment for the action of the antibiotics. 3As reported by several authors, a short-term therapy with omeprazole in combination with clarithromycin and either amoxycillin or metronidazole can achieve eradication rates of above 90%. 4±6 These regimens were

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Eradication of Helicobacter pylori with pantoprazole and two antibiotics: a comparison of two short‐term regimens

Frevel¹,

Daake²,

Janisch³

et al. 2000

Aliment Pharmacol Ther

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“…[87] The major result of the aforementioned metaanalysis comparing pantoprazole with other PPIs (such as omeprazole or lansoprazole) as eradication therapy against H. pylori is that the results are the same regardless of the PPI used. [78] Thus, as graphically presented in figure 2 derived from the seven studies [88][89][90][91][92][93][94] included in the meta-analysis in which 534 patients received pantoprazole and 603 patients received other PPIs, the mean H. pylori eradication rate was 83% and 81%, respectively. The OR for this comparison was exactly 1 (95% CI, 0.61-1.64).…”

Section: Pantoprazolementioning

confidence: 99%

“…Intention-to-treat analysis. [88][89][90][91][92][93][94] OR ¼ odds ratio; 95% CI ¼ 95% confidence interval.…”

Section: Rabeprazolementioning

confidence: 99%

Potent Gastric Acid Inhibition in Helicobacter pylori Eradication

Gisbert

2005

Drugs

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At present, antisecretory drugs -foremost among them the proton pump inhibitors (PPIs) -represent a keystone in Helicobacter pylori eradication therapy. The present article shall first compare the role of PPIs as compared with histamine H 2 receptor antagonists, both of them in the role of antibiotic-associated antisecretory therapy, and shall then address the contribution of each of the various PPIs that have been developed until the present time to the H. pylori eradication therapies. In summary, it may be concluded that PPIs are more effective overall than H 2 receptor antagonists when the two groups of antisecretory drugs are given at the usual standard doses together with antibiotics with the intention of eradicating H. pylori infection. However, all PPIs (omeprazole, lansoprazole, pantoprazole, rabeprazole, and esomeprazole) are equivalent when given together with two antibiotics to cure the infection.

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Tratamiento erradicador de Helicobacter pylori. Recomendaciones de la Conferencia Española de Consenso

et al. 2000

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Efficacy of six days triple therapy with pantoprazole plus clarithromycin and amoxycillin versus omeprazole plus clarithromycin and amoxycillin for H. pylori eradication

Cited by 5 publications

References 0 publications

Eradication of Helicobacter pylori with pantoprazole and two antibiotics: a comparison of two short‐term regimens

Eradication of Helicobacter pylori with pantoprazole and two antibiotics: a comparison of two short‐term regimens

Potent Gastric Acid Inhibition in Helicobacter pylori Eradication

Tratamiento erradicador de Helicobacter pylori. Recomendaciones de la Conferencia Española de Consenso

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