Potent Gastric Acid Inhibition in Helicobacter pylori Eradication

Abstract

At present, antisecretory drugs -foremost among them the proton pump inhibitors (PPIs) -represent a keystone in Helicobacter pylori eradication therapy. The present article shall first compare the role of PPIs as compared with histamine H 2 receptor antagonists, both of them in the role of antibiotic-associated antisecretory therapy, and shall then address the contribution of each of the various PPIs that have been developed until the present time to the H. pylori eradication therapies. In summary, it may be concluded that PPIs are more effective overall than H 2 receptor antagonists when the two groups of antisecretory drugs are given at the usual standard doses together with antibiotics with the intention of eradicating H. pylori infection. However, all PPIs (omeprazole, lansoprazole, pantoprazole, rabeprazole, and esomeprazole) are equivalent when given together with two antibiotics to cure the infection.

Effects of Pantoprazole in experimental acute pancreatitis

“…By this mechanism, acid secretion can be effectively reduced which makes PPZ the gold standard therapy for gastric acid related disorders like GERD or Helicobacter pylori associated ulcers (Khan et al 2007;Gisbert 2005). In this context, PPZ is usually combined with two or three antibiotics to maximize the therapeutic efficacy.…”

Gastroprotective Effect of Guttarda speciosa against Ethanol Induced Gastric Ulcer in Rats

“…Presently used antisecretory agents like proton pump inhibitors may represent a key option in peptic ulcer therapy [3] but their prolonged use seems to be associated with high incidence of hip fractures. NSAIDs induced gastropathy remains a major clinical problem [4] which has not been solved through the introduction of selective inhibitors of cyclooxygenase-2 (COX-2) due to cardiac side effects [5].…”

Letter: clarithromycin dose for H. pylori therapy remains unresolved

“…4 Effective anti-microbial therapy depends on the pharmokinetics of the drugs, the tissue and blood drug levels, anti-microbial susceptibility, 5 and with triple therapy with the degree of inhibition of gastric acidity. 6 The Helicobacter field has seen many examples of meta-analyses which ignored the overriding effects of antibiotic resistance on outcome and resulted false claims of equivalence or superiority in the presence of unacceptable low cure rates. [7][8][9] Clarithromycin resistance has continued to increase 10 ;…”