Efficacy of single application of topical doxycycline hyclate and triamcinolone acetonide in denture adhesive in the management of recurrent aphthous stomatitis: A comparative study

Chandak, Rakhi; Sonule, Sonal; Chandak, Manoj; Rawlani, Shivlal; Gaikwad, Romita

doi:10.4103/jorr.jorr_43_16

Cited by 4 publications

(25 citation statements)

References 1 publication

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“…All included studies found single application of doxycycline to be effective in reducing signs and symptoms of RAS [4,13,[17][18][19].…”

Section: Qualitative Resultsmentioning

confidence: 99%

“…Diagnosis of RAS was based on clinical features and history of recurrent minor ulcers. The duration of RAS at the time of recruitment was reported by three studies [4,18,19], which ranged between 10 h and 72 h. However, no information was given about RAS duration (before intervention) by the other two studies [13,17].…”

Section: General Characteristics Of the Included Studiesmentioning

confidence: 99%

“…In all included studies, a single dose of topical doxycycline was applied. The efficacy of doxycycline was compared with placebo in three studies [4,13,17]; 0.1% triamcinolone acetonide in one study [19]; and with four control groups in one study [18]: 5% amlexanox, 0.1% triamcinolone acetonide, 20% Benzocaine gel, and placebo gel ( Table 2).…”

Section: Intervention and Control Groupsmentioning

confidence: 99%

“…All the included studies reported on this outcome; three studies [4,13,17] reported a significant reduction of pain with doxycycline intervention compared to placebo. Two studies [18,19] found doxycycline as effective as 0.1% triamcinolone acetonide in reducing pain (Table 2).…”

Section: Reduction Of Painmentioning

confidence: 99%

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Single application of topical doxycycline in management of recurrent aphthous stomatitis: a systematic review and meta-analysis of the available evidence

et al. 2020

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Background: Recurrent aphthous stomatitis (RAS) is a highly prevalent oral mucosal disease. The management of RAS is quite challenging, and as yet, there is no definitive cure. The present systematic review and meta-analysis assessed the efficacy of a single application of topical doxycycline for the management of RAS. Methods: A comprehensive online search of PubMed, Scopus, Embase, and Web of Science databases was conducted to identify all relevant studies published up to March 31, 2019. All randomized clinical trials that assessed the efficacy of a single application of topical doxycycline in the management of RAS were included. Primary outcome measures were pain scores and/or healing time, while secondary outcomes included the associated side effects. RevMan 5.3 software was used for data analysis. Results: Five clinical trials fulfilled the eligibility criteria, three of which were included in the meta-analysis. All of the included studies found doxycycline effective in alleviating signs and symptoms of RAS. The results of the pooled 3 studies revealed a statistically significant decrease in the healing time in favor of the doxycycline group as compared to the control groups (I 2 = 51%; MD:-1.77, 95% CI: − 2.11, − 1.42, P <0.00001); however, the results showed no significant differences between doxycycline and control groups with regard to pain reduction (I 2 = 96%; MD:-1.28, 95% CI: − 2.83, 0.27; P = 0.11). Conclusion: Although still inconclusive, the available evidence suggests that a single application of topical doxycycline might be effective for reducing signs and symptoms of RAS. However, owing to the limited number of the included studies, further well-designed clinical trials with adequate sample sizes are required to discern the clinical efficacy of topical doxycycline in patients with RAS.

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“…All included studies found single application of doxycycline to be effective in reducing signs and symptoms of RAS [4,13,[17][18][19].…”

Section: Qualitative Resultsmentioning

confidence: 99%

Section: General Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Intervention and Control Groupsmentioning

confidence: 99%

Section: Reduction Of Painmentioning

confidence: 99%

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Single application of topical doxycycline in management of recurrent aphthous stomatitis: a systematic review and meta-analysis of the available evidence

et al. 2020

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“…Topical treatments include natural therapeutic products as well as topical therapeutic methods such as topical application of growth factors, oxidized regenerated cellulose/collagen, hyaluronic acid conjugated with glycidyl methacrylate or gelatin dressings and insulin. 2 In addition, for treatment of chronic oral ulcers advanced expertise in different topical medication were introduced as antiseptics (chlorhexidine) 11 , anti-inflammatory drugs (amlexanox 12 ), antibiotics (tetracyclines) 13 and corticosteroids (prednisone) 14 and immune-modulators (pentoxifylline). 15 The purpose of this study was to introduce and add to the field of oral ulcers treatment using topical medications a new innovation, which is topical insulin, and to evaluate its effectiveness on oral ulcers in diabetic and non-diabetic rats through histological examinations.…”

Section: Introductionmentioning

confidence: 99%

Impact of Topical Insulin on Oral Mucosal Wound Healing in Diabetic and Non Diabetic Rats

Basha

2018

Egyptian Dental Journal

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Diabetes mellitus is a chronic, lifelong metabolic disorder. Impaired wound healing capabilities in both cutaneous and oral ulceration was denoted among diabetic patients. Topical treatments include natural therapeutic products as oxidized regenerated cellulose/collagen, hyaluronic acid conjugated with glycidyl methacrylate or gelatin dressings and insulin. Different studies have proved the efficacy of topical insulin on skin ulcers. The aim of the present study was to evaluate the effectiveness of topical insulin on oral ulcers in diabetic and non-diabetic rats through histological examinations. Material and methods: 48 male albino rats were used in this study, rat population was divided into diabetic and non-diabetic groups. Each group was subdivided into test subgroup treated by insulin and control subgroup treated by placebo. Histological examination was performed to rats sacrificed after 2, 7 and 14 days. Results: Better healing was observed in nondiabetic groups compared to diabetic groups. Improved healing was noticed in groups treated by insulin manifested by hyperplastic orthokeratinized epithelium with prominent granular cell layer, while ulceration was still denoted in the groups treated by plecebo. Conclusion: From the present study, it was concluded that topical insulin can be considered as a safe and effective treatment modality for oral ulcers.

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Dissolvable and layered microneedles composed of hyaluronate/rbFGF/CPC effectively improve the treatment effect on recurrent aphthous ulcers

et al. 2022

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Efficacy of single application of topical doxycycline hyclate and triamcinolone acetonide in denture adhesive in the management of recurrent aphthous stomatitis: A comparative study

Cited by 4 publications

References 1 publication

Single application of topical doxycycline in management of recurrent aphthous stomatitis: a systematic review and meta-analysis of the available evidence

Single application of topical doxycycline in management of recurrent aphthous stomatitis: a systematic review and meta-analysis of the available evidence

Impact of Topical Insulin on Oral Mucosal Wound Healing in Diabetic and Non Diabetic Rats

Dissolvable and layered microneedles composed of hyaluronate/rbFGF/CPC effectively improve the treatment effect on recurrent aphthous ulcers

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