Efficacy of Rice‐based Oral Rehydration Solution Containing Recombinant Human Lactoferrin and Lysozyme in Peruvian Children With Acute Diarrhea

Zavaleta, Nelly; Figueroa, Dante; Rivera, Juan; Sánchez, John Paul; Segundo, Alfaro; Lönnerdal, Bo

doi:10.1097/mpg.0b013e31802c41b7

Cited by 117 publications

(81 citation statements)

References 30 publications

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“…A study of 140 Peruvian children with acute watery diarrhea and dehydration showed that adding recombinant human lactoferrin and lysozyme (Ventria Bioscience, Sacramento, CA) to oral rehydration solution reduced the duration of diarrhea (3.7 days vs. 5.2 days, p = 0.05) and relapse after 48 h (9% vs. 19%) [53].…”

Section: Clinical Studies Of Lactoferrin's Effect On Enteric Pathogensmentioning

confidence: 99%

Effect of lactoferrin on enteric pathogens

Ochoa

Cleary²

2009

Biochimie

118

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Much has been learned in recent years about the mechanisms by which breastfeeding improves child health and survival. However, there has been little progress in using these insights to improve pediatric care. Factors that are important for protecting the breast fed infant might be expected to decrease the adverse effects of weaning on diarrhea, growth, and development. Lactoferrin, an ironbinding protein with multiple physiological functions (anti-microbial, anti-inflammatory, and immunomodulatory), is one of the most important proteins present in mammalian milk. Protection against gastroenteritis is the most likely biologically relevant activity of lactoferrin. Multiple in vitro and animal studies have shown a protective effect of lactoferrin on infections with enteric microorganisms, including rotavirus, Giardia, Shigella, Salmonella and the diarrheagenic Escherichia coli. Lactoferrin has two major effects on enteric pathogens: it inhibits growth and it impairs function of surface expressed virulence factors thereby decreasing their ability to adhere or to invade mammalian cells. Thus, lactoferrin may protect infants from gastrointestinal infection by preventing the attachment by enteropathogens in the gut. Recently several clinical trials in children have started to address this issue. Whether lactoferrin can prevent a significant portion of diarrheal disease remains to be determined.

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Section: Clinical Studies Of Lactoferrin's Effect On Enteric Pathogensmentioning

confidence: 99%

Effect of lactoferrin on enteric pathogens

Ochoa

Cleary²

2009

Biochimie

118

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“…Safety relevant endpoints were not studied. In two studies in Peruvian children which reported on adverse events the number of adverse events did not differ between the treatment and the placebo group and no adverse event could be attributed to the test substance (Ochoa et al, 2008;Zavaleta et al, 2007).…”

Section: Studies In Childrenmentioning

confidence: 99%

“…Four published studies with a duration of fifteen days to nine months investigated presumed antimicrobial effects of bLF at intakes between 100 and 1,000 mg per day alone or in coadministration with other substances (Ajello et al, 2002;Egashira et al, 2007;Ochoa et al, 2008;Zavaleta et al, 2007). Safety relevant endpoints were not studied.…”

Section: Studies In Childrenmentioning

confidence: 99%

Scientific Opinion on bovine lactoferrin

Products¹

2012

EFSA Journal

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Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to carry out the additional assessment of "lactoferrin" as a food ingredient in the context of Regulation (EC) No 258/97 taking into account the comments and objections of a scientific nature raised by Member States. Bovine lactoferrin (bLF) is a protein that occurs naturally in cow"s milk. The applicant intends to market bLF as an ingredient for food supplements, infant and follow-on formulae, dietetic food for special medical purposes and sports nutrition, and for a variety of foods. For infants with an age of 0 -6 months, the applicant has estimated an intake of approximately 200 mg per kg bodyweight and 1.2 g bLF per day at the proposed use level. For adults, the mean and 95 th percentile daily intakes were calculated to be about 1.4 g and 3.4 g for an adult person. The toxicological information provided by the applicant included information from an in vitro genotoxicity study, a single dose study, a four week and a thirteen week oral repeated dose study in rats. The Panel notes that the estimated intake of "lactoferrin" for infants up to the age of one year of approximately 210 mg/kg bw per day would be around ten times lower than the highest dose (2,000 mg/kg bw per day) tested in the subchronic thirteen week rat study, which did not show adverse effects related to bLF. For adults above 19 years of age the proposed intake is approximately 100 times lower. This level of anticipated intake is considered a high intake scenario as opposed to a worst-case situation. The data provided suggest the absence of adverse effects of lactoferrin at the proposed levels of consumption. The Panel concludes that the novel food ingredient bLF is safe under the proposed uses and use levels. © European Food Safety Authority, 2012 KEY WORDSBovine lactoferrin, novel food, ingredient Bovine lactoferrin (bLF) is a protein that occurs naturally in cow"s milk. The applicant intends to market bLF in isolated and purified form. bLF is an iron-binding glycoprotein of approximately 77 kDa and consists of a single polypeptide chain of about 700 amino acids. The sequence homology between human and bLF is about 70 %. The tertiary structure of this glycoprotein has two ironbinding sites, giving it the capability to bind two Fe 3+ ions per molecule of protein. Batch testing confirmed that the product complies with the given specifications. bLF from skimmed milk is concentrated via ion exchange and is subsequently subjected to filtration steps. Ultimately the bLF is dried by means of spray drying. The applicant provided sufficient information regarding the specification, manufacture, composition and stability of bLF.The applicant intends to market bLF as an ingredient for food supplements, infant and follow-on formulae, dietetic food for special medical purposes and sports nutrition, and for foods such as nonalcoholic beverages, cakes and pastries, products derived from cheese, milk-based products, cold snacks...

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“…In a research to investigate the efficacy of R-ORS compared to G-ORS, in treating children with acute watery diarrhea, R-ORS was more effective in reducing the duration of diarrhea and hospital stay, although no significant effect was found on stool output or intravenous fluid administering frequency (15). Some other studies have found no significant difference between R-ORS and G-ORS in the treatment of children with diarrhea (13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

The Effect of G-ORS Along With Rice Soup in the Treatment of Acute Diarrhea in Children: A Single-Blind Randomized Controlled Trial

Kianmehr¹,

Saber²,

Moshari³

et al. 2016

Nurs Midwifery Stud

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Background: The world health organization guidelines for treatment of diarrhea in children emphasize on continued feeding together with prescription of oral rehydration solution (ORS) and supplementary zinc therapy. However, conflicting viewpoints exist regarding the optimal diet and dietary ingredients for children with diarrhea. Moreover, few studies have investigated the effect of rice soup along with ORS in the treatment of this disease.

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Efficacy of Rice‐based Oral Rehydration Solution Containing Recombinant Human Lactoferrin and Lysozyme in Peruvian Children With Acute Diarrhea

Abstract: Addition of recombinant human lactoferrin and lysozyme to a rice-based oral rehydration solution had beneficial effects on children with acute diarrhea.

Cited by 117 publications

References 30 publications

Effect of lactoferrin on enteric pathogens

Effect of lactoferrin on enteric pathogens

Scientific Opinion on bovine lactoferrin

The Effect of G-ORS Along With Rice Soup in the Treatment of Acute Diarrhea in Children: A Single-Blind Randomized Controlled Trial

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