Effect of lactoferrin on enteric pathogens

Ochoa, Theresa J.; Cleary, Thomas G.

doi:10.1016/j.biochi.2008.04.006

Cited by 114 publications

(95 citation statements)

References 56 publications

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“…Additionally, more virulence EAEC genes detected corresponded to a rise in the fecal lactoferrin level ( Table 6 ). The protective function of lactoferrin on infections with enteropathogens have been acknowledged, 56 and colonization/infection, particularly by EAEC in the current study probably contributed to the high lactoferrin levels ( Table 6 ).…”

mentioning

confidence: 68%

Pediatric Diarrhea in Southern Ghana: Etiology and Association with Intestinal Inflammation and Malnutrition

Opintan¹,

Newman²,

Ayeh‐Kumi³

et al. 2010

The American Journal of Tropical Medicine and Hygiene

100

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Abstract. Diarrhea is a major public health problem that affects the development of children. Anthropometric data were collected from 274 children with ( N = 170) and without ( N = 104) diarrhea. Stool specimens were analyzed by conventional culture, polymerase chain reaction for enteroaggregative Escherichia coli (EAEC), Shigella , Cryptosporidium , Entamoeba , and Giardia species, and by enzyme-linked immunosorbent assay for fecal lactoferrin levels. About 50% of the study population was mildly to severely malnourished. Fecal lactoferrin levels were higher in children with diarrhea ( P = 0.019). Children who had EAEC infection, with or without diarrhea, had high mean lactoferrin levels regardless of nutritional status. The EAEC and Cryptosporidium were associated with diarrhea ( P = 0.048 and 0.011, respectively), and malnourished children who had diarrhea were often co-infected with both Cryptosporidium and EAEC. In conclusion, the use of DNA-biomarkers revealed that EAEC and Cryptosporidium were common intestinal pathogens in Accra, and that elevated lactoferrin was associated with diarrhea in this group of children.

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mentioning

confidence: 68%

Pediatric Diarrhea in Southern Ghana: Etiology and Association with Intestinal Inflammation and Malnutrition

Opintan¹,

Newman²,

Ayeh‐Kumi³

et al. 2010

The American Journal of Tropical Medicine and Hygiene

100

View full text Add to dashboard Cite

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“…As reviewed in reference 670, in a vaccine study using the ETEC heat-labile toxin, the rate of infection and severity of disease caused by ETEC was decreased, and despite the presence of EAEC in the placebo groups, the vaccine-treated group had no EAEC detected, suggesting that the vaccine may also exert protection against EAEC (687). In vitro treatment with lactoferrin inhibits EAEC enteroadhesion and biofilm formation, making it a potential but untested nonantibiotic treatment for the prevention of EAEC (670,688).…”

Section: Clinical Considerationsmentioning

confidence: 99%

Recent Advances in Understanding Enteric Pathogenic Escherichia coli

et al. 2013

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SUMMARY Although Escherichia coli can be an innocuous resident of the gastrointestinal tract, it also has the pathogenic capacity to cause significant diarrheal and extraintestinal diseases. Pathogenic variants of E. coli (pathovars or pathotypes) cause much morbidity and mortality worldwide. Consequently, pathogenic E. coli is widely studied in humans, animals, food, and the environment. While there are many common features that these pathotypes employ to colonize the intestinal mucosa and cause disease, the course, onset, and complications vary significantly. Outbreaks are common in developed and developing countries, and they sometimes have fatal consequences. Many of these pathotypes are a major public health concern as they have low infectious doses and are transmitted through ubiquitous mediums, including food and water. The seriousness of pathogenic E. coli is exemplified by dedicated national and international surveillance programs that monitor and track outbreaks; unfortunately, this surveillance is often lacking in developing countries. While not all pathotypes carry the same public health profile, they all carry an enormous potential to cause disease and continue to present challenges to human health. This comprehensive review highlights recent advances in our understanding of the intestinal pathotypes of E. coli .

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“…The inhibitory action of camel milk against L. monocytogenes, S. aureus and E. coli has been attributed to the presence of lactoperoxidase, hydrogen peroxide and lysozyme, respectively. The growth of Salmonella typhimurium is inhibited by lactoferrin in camel milk through binding iron and making it unavailable for its growth [26,84]. It is demonstrated that the potential for camel lactoferrin to inhibit HCV entry into human leukocytes is with more efficiency than human or bovine lactoferrin [31].…”

Section: Antibacterial Activitymentioning

confidence: 99%

Camel Milk: An Important Natural Adjuvant

et al. 2017

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One humped camel (Camelus dromedarius) breeds, indigenous to India, have been shown to have good genetic potential to produce milk. Camel milk not only is cost-effective in terms of feed conversion but also has additional advantage of longer lactation period and unique adaptation mechanisms for warm arid and semiarid regions. The key features of camel milk in comparison with other milk are low fat with high content of unsaturated and long-chain fatty acid. The proteins are rich in lactoferrin and lysozymes, but deficient in b-lactoglobulin. It has higher percentage of total salts, free calcium, protective proteins and vitamin C, and some of the microminerals, viz iron, copper and zinc. Physicochemical properties of camel milk are also unique and useful for food processing. The shelf life of raw camel milk is 8-9 h, which can be extended up to 18-20 h through activation of camel lactoperoxidase system. Heat stability of camel milk is shown to be highest at pH 6.8, and it ferments relatively slowly compared to the cattle milk. The camel milk is successfully processed for producing a variety of products, such as fermented milk ('lassi'), soft cheese, flavored milk and 'kulfee' (a kind of ice cream). Camel milk has been traditionally used in different regions of the world as natural adjuvant for managing a variety of human diseases.

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Effect of lactoferrin on enteric pathogens

Cited by 114 publications

References 56 publications

Pediatric Diarrhea in Southern Ghana: Etiology and Association with Intestinal Inflammation and Malnutrition

Pediatric Diarrhea in Southern Ghana: Etiology and Association with Intestinal Inflammation and Malnutrition

Recent Advances in Understanding Enteric Pathogenic Escherichia coli

Camel Milk: An Important Natural Adjuvant

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