Efficacy of rabies biologics against new lyssaviruses from Eurasia

Hanlon, Cathleen A.; Kuzmin, Ivan V.; Blanton, Jesse D.; Weldon, William C.; Manangan, Jamie; Rupprecht, Charles E.

doi:10.1016/j.virusres.2005.03.009

Cited by 157 publications

(119 citation statements)

References 27 publications

Supporting

Mentioning

109

Contrasting

Unclassified

Order By: Relevance

“…For instance, when sera of EBLV-1 and EBLV-2 experimentally infected ferrets [34] were serologically investigated against EBLV-1 and EBLV-2, sera had lower neutralizing activity using the heterologous test virus (T. Müller et al, unpublished data). Similar reactions were reported from serological tests with Aravan virus (ARAV) and Khujand virus (KHUV) [51]. In this respect we are aware of the fact that by using one test virus only we may have missed seroconversion in other bat species, in particular in Myotis species.…”

Section: Discussionsupporting

confidence: 73%

Twenty years of active bat rabies surveillance in Germany: a detailed analysis and future perspectives

Schatz

Ohlendorf²,

Busse³

et al. 2013

Epidemiol. Infect.

View full text Add to dashboard Cite

SUMMARYIn Germany, active bat rabies surveillance was conducted between 1993 and 2012. A total of 4546 oropharyngeal swab samples from 18 bat species were screened for the presence of EBLV-1-, EBLV-2-and BBLV-specific RNA. Overall, 0·15% of oropharyngeal swab samples tested EBLV-1 positive, with the majority originating from Eptesicus serotinus. Interestingly, out of seven RT-PCR-positive oropharyngeal swabs subjected to virus isolation, viable virus was isolated from a single serotine bat (E. serotinus). Additionally, about 1226 blood samples were tested serologically, and varying virus neutralizing antibody titres were found in at least eight different bat species. The detection of viral RNA and seroconversion in repeatedly sampled serotine bats indicates long-term circulation of the virus in a particular bat colony. The limitations of random-based active bat rabies surveillance over passive bat rabies surveillance and its possible application of targeted approaches for future research activities on bat lyssavirus dynamics and maintenance are discussed.

show abstract

Section: Discussionsupporting

confidence: 73%

Twenty years of active bat rabies surveillance in Germany: a detailed analysis and future perspectives

Schatz

Ohlendorf²,

Busse³

et al. 2013

Epidemiol. Infect.

View full text Add to dashboard Cite

show abstract

“…Serologic cross-reactivity between LBV and MOKV has been demonstrated previously (Shope et al, 1970;Hanlon et al, 2005). Therefore, based on our cumulative serologic results, we have no substantive reason to consider the possibility of MOKV circulation in bats.…”

mentioning

confidence: 44%

“…Human consumption of bats is practiced in many parts of Nigeria, and the public health implication of this practice remains to be assessed. Surveillance is particularly important for nonrabies lyssaviruses because commercially available rabies biologics do not provide reliable protection against LBV, MOKV, and West Causcasian bat virus (WCBV) (Hanlon et al, 2005). In this study, we performed active surveillance for lyssaviruses among bats in the northern part of Nigeria in order to provide the baseline information necessary to begin assessment of the epidemiology of lyssaviruses in this part of the world.…”

mentioning

confidence: 99%

Evidence of Lagos Bat Virus Circulation among Nigerian Fruit Bats

Dzikwi

Kuzmin

Umoh

et al. 2010

Journal of Wildlife Diseases

Self Cite

View full text Add to dashboard Cite

“…We have shown that LBV infection may be present in bat populations; consequently, we recommend appropriate precautions and use of proper personal protection equipment, such as gloves, when interacting with these animals. Even though the value of rabies vaccination is doubtful, it should be considered in light of the potential for cross-reactivity ( 15 ) and the lack of alternatives. Surveillance should be maintained as part of a strategy to better understand the epidemiology of LBV.…”

Section: Discussionmentioning

confidence: 99%