Efficacy of probiotics in the treatment of pediatric atopic dermatitis: a meta-analysis of randomized controlled trials

Lactococcus lactisas an adjuvant and delivery vehicle of antigens against pneumococcal respiratory infections

“…In this sense, lactic acid bacteria (LAB), microorganisms with GRAS (Generally Recognized As Safe) status, some of them with important immunostimulant properties and positive effects on human and animal health, [5][6][7] represent an interesting alternative for the development of a mucosal vaccine. The most common lactic acid bacterium used as a vehicle of antigen presentation is Lactococcus lactis, a bacterium extensively engineered for the production of heterologous bacterial and viral proteins.…”

Additional probiotic therapy lowers SCORAD index in children with atopic dermatitis

“…Other meta-analytical studies also found variable probiotic effects in AD. (14,20) Highly heterogenous conditions, including differences in probiotic preparations, study populations and the final results of measurement can directly affect the comparative results of these studies.…”

The Role of Probiotics in Atopic Dermatitis Prevention and Therapy

“…Duration of probiotic administration, age, and type of probiotic used did not affect outcome. Data from this meta-analysis suggest a modest role for probiotics in pediatric AD and the effect is seen in moderately severe rather than mild disease [94]. Lee et al meta-analyzed 10 double-blind randomized controlled clinical trials.…”

“…A significant overall benefit was demonstrated after the use of probiotics, resulting in a reduction of the SCORAD scores compared to placebo. LGG appeared to be more effective than other probiotic preparations and children with more severe disease were more likely to benefit from the use of probiotics [94]. This remarkable meta-analysis was done to determine whether probiotics are efficacious in treating AD and to explore whether type of probiotic used, duration of therapy, patient age, severity of disease, and IgE sensitization are factors in determining efficacy.…”