The Role of Probiotics in Atopic Dermatitis Prevention and Therapy

Özdemir, Öner

doi:10.5772/25301

Cited by 2 publications

(1 citation statement)

References 113 publications

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“…Therefore, promotion of Th1 immunity and suppression of Th2 immunity can be an effective therapeutic measure for AD [ 6 , 7 ]. In fact, some strains of probiotic bacteria have been reported to exert beneficial effects in AD by promoting IFN-γ production [ 8 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of diet supplemented with rice prolamin extract against DNCB-induced atopic dermatitis in BALB/c mice

Yoon

Jang

Kim

et al. 2015

BMC Complement Altern Med

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BackgroundRice prolamin has been reported to possess antioxidative, anti-inflammatory and immune-promoting properties. This study is aimed to examine the protective effects of dietary rice prolamin extract (RPE) against dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions in mice.MethodsBALB/c mice were fed diet supplemented with 0–0.1 % RPE for 6 weeks. For the last 2 weeks, 1 % or 0.2 % DNCB was applied repeatedly to the back skin of mice to induce AD-like lesions. Following AD induction, the severity of skin lesions was examined macroscopically and histologically. In addition, the serum levels of IgE, IgG1 and IgG2a were determined by ELISA, and the mRNA expression of IL-4 and IFN-γ in the skin was determined by real-time PCR.ResultsDietary RPE suppressed the clinical symptoms of DNCB-induced dermatitis as well as its associated histopathological changes such as epidermal hyperplasia and infiltration of mast cells and eosinophils in the dermis. RPE treatment also suppressed the DNCB-induced increase in transepidermal water loss. Dietary RPE inhibited the DNCB-induced enhancement of serum IgE and IgG1 levels, whereas it increased the serum IgG2a level in DNCB-treated mice. In addition, dietary RPE upregulated the IFN-γ mRNA expression and downregulated the IL-4 mRNA expression in the skin of DNCB-treated mice.ConclusionsThe above results suggest that dietary RPE exerts a protective effect against DNCB-induced AD in mice via upregulation of Th1 immunity and that RPE may be useful for the treatment of AD.

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Section: Introductionmentioning

confidence: 99%

Protective effect of diet supplemented with rice prolamin extract against DNCB-induced atopic dermatitis in BALB/c mice

Yoon

Jang

Kim

et al. 2015

BMC Complement Altern Med

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Çocuklarda Profilaktik ve Terapötik Probiyotik Kullanımı

Tüsüz Önata,

Özdemir

2024

Journal of Biotechnology and Strategic Health Research

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Probiyotikler uygun miktarda uygulandıklarında kişiye sağlık açısından fayda sağlayan canlı mikroorganizmalardır. Probiyotikler bağırsak epiteli ve mukusuna yapışma yetenekleri sayesinde patojenlerle yarışarak patojen istilasını azaltırlar, bakteriyosin, hidrojen peroksit ve organik asitler gibi antimikrobiyal ürünler üretip antimikrobiyal etki sağlarlar. Bu etkileri sayesinde probiyotiklerin özellikle gastrointestinal sistem hastalıklarının önlenmesi ve tedavisinde kullanımı uzun yıllardır araştırma konusu olmuştur. Probiyotiklerin regülatör T hücre üretiminin indüklenmesi, alerjenlere cevabın Th1 yönüne saptırılması gibi sistemik etkileri olması alerjik hastalıklarda kullanımı için umut olmuştur. Son yıllarda probiyotiklerin profilaktik veya tedavi amaçlı kullanıldığı pek çok hastalıkla ilgili araştırmalar yapılmaktadır. Bu çalışmalardan probiyotiklerin etkinliğinin suş ve hastalık açısından özel olduğunu gösteren önemli kanıtlar elde edilmiştir. Bu yazının amacı probiyotiklerin hastalık tipine bağlı kullanımını güncel bilgiler ışığında gözden geçirmektir.

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The Role of Probiotics in Atopic Dermatitis Prevention and Therapy

Cited by 2 publications

References 113 publications

Protective effect of diet supplemented with rice prolamin extract against DNCB-induced atopic dermatitis in BALB/c mice

Protective effect of diet supplemented with rice prolamin extract against DNCB-induced atopic dermatitis in BALB/c mice

Çocuklarda Profilaktik ve Terapötik Probiyotik Kullanımı

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