Efficacy of platelet-rich plasma in alveolar bone grafting

Oyama, T; Nishimoto, Soh; Tsugawa, Tomoe; Shimizu, Fumiaki

doi:10.1016/j.joms.2003.08.023

Cited by 139 publications

(115 citation statements)

References 11 publications

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“…In goats, autogenous bone showed considerable improvements in the bone repair, with increase of the revascularization, reduction of the reabsortion and increase of the bone neoformation, mainly after six and 12 weeks; the beneficial effect of the PRP were also observed later on 19 . Although it is known that the growth factors are delivered during few days after the local application, according to these authors, their initial effect can be important once they can promote the revascularization and also tissue acceptance of the grafted material.…”

Section: Discussionmentioning

confidence: 96%

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Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

et al. 2010

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PURPOSE: To verify the effect of highly concentrated platelet-rich plasma (hPRP) in the pathways of bone repair using non-critical defects in the calvaria of rabbits. METHODS: The hPRP was produced from collected venous blood of 21 rabbits. Four non-critical defects of 8 mm in diameter were created on the calvaria of each animal. The defects were all treated differently: autogenous particled bone (APB, group 1), autogenous particled bone associated with hPRP (APB + hPRP, group 2), isolated hPRP (group 3), and blood clot (control, group 4). Animals were submitted to euthanasia on the 2nd, 4th and 6th week postoperatively. Histological and histomorphometric analysis were carried through. RESULTS: After two weeks, groups 1 and 2 were in more advanced stage of repair than 3 and 4. At this period, comparing the groups 1 and 2, no significant differences were found between both, which also happened between the groups 3 and 4. However, after four and six weeks, the group 1 showed a more advanced stage of repair among all the other studied groups, while group 2 was in more advanced signs of bone repair than groups 3 and 4. Comparing groups 3 and 4, after four and six weeks, the least advanced stage of bone repair was found to be within group 3. CONCLUSION: The use of a highly concentrated PRP was considered prejudicial to the repair of non-critical defects in the calvaria of rabbits, either in the association of autogenous particled bone, when compared to autogenous particled bone alone, or in its isolated form, when compared to blood clot (control).

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Section: Discussionmentioning

confidence: 96%

“…In humans, many authors demonstrate positive results with the use of PRP in situations of tissue repair 2,3,17,[18][19][20][21][22] , while others, however, do not observe benefits 9,23 .…”

Section: Discussionmentioning

confidence: 99%

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

et al. 2010

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“…Although many controversial results are reported, PRP is also widely used in the field of bone tissue engineering. Clinical studies by Marx et al (1998) and Oyama et al (2004) in the field of oral-maxillofacial reconstructions showed a strong effect of PRP on bone formation (88 and 12 patients, respectively), while there was weak to absent effect on bone formation in other studies investigating 26 and 10 patients (Dori et al, 2008;Kassolis and Reynolds, 2005).…”

Section: Clinical Use Of Prpmentioning

confidence: 93%

State of the art and future perspectives of articular cartilage regeneration: a focus on adipose-derived stem cells and platelet-derived products

Hildner

Albrecht

Gabriel

et al. 2011

J Tissue Eng Regen Med

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Trauma, malposition and age-related degeneration of articular cartilage often result in severe lesions that do not heal spontaneously. Many efforts over the last centuries have been undertaken to support cartilage healing, with approaches ranging from symptomatic treatment to structural cartilage regeneration. Microfracture and matrix-associated autologous chondrocyte transplantation (MACT) can be regarded as one of the most effective techniques available today to treat traumatic cartilage defects. Research is focused on the development of new biomaterials, which are intended to provide optimized physical and biochemical conditions for cell proliferation and cartilage synthesis. New attempts have also been undertaken to replace chondrocytes with cells that are more easily available and cause less donor site morbidity, e.g. adipose derived stem cells (ASC). The number of in vitro studies on adult stem cells has rapidly increased during the last decade, indicating that many variables have yet to be optimized to direct stem cells towards the desired lineage. The present review gives an overview of the difficulties of cartilage repair and current cartilage repair techniques. Moreover, it reviews new fields of cartilage tissue engineering, including stem cells, co-cultures and platelet-rich plasma (PRP).

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“…O plasma rico em plaquetas (PRP) é a fonte de FCs mais utilizada em enxertos ósseos, fornecendo dois dos principais FCs envolvidos no reparo ósseo: PDGF e TGFβ. Adicionalmente, o PRP pode ser obtido e aplicado ao foco de fratura por técnicas relativamente simples e pouco onerosas (OYAMA et al, 2004).…”

Section: Potencial Terapêutico Dos Fatores De Crescimentounclassified

“…A centrifugação repetida em duas etapas foi utilizada por OYAMA et al (2004) com resultados igualmente positivos. O sangue colhido é centrifugado a 160g a por 20 minutos, e o plasma sobrenadante resultante, juntamente com 6mm da fração vermelha, é centrifugado a 400g por 15 minutos.…”

Section: Potencial Terapêutico Dos Fatores De Crescimentounclassified

Considerações sobre a obtenção e o uso do plasma rico em plaquetas e das células mesenquimais indiferenciadas em enxertos ósseos

Pagliosa

Alves

2007

Cienc. Rural

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Efficacy of platelet-rich plasma in alveolar bone grafting

Cited by 139 publications

References 11 publications

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

State of the art and future perspectives of articular cartilage regeneration: a focus on adipose-derived stem cells and platelet-derived products

Considerações sobre a obtenção e o uso do plasma rico em plaquetas e das células mesenquimais indiferenciadas em enxertos ósseos

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