Efficacy of photodynamic therapy versus antibiotics as an adjunct to scaling and root planing in the treatment of periodontitis: A systematic review and meta-analysis

Akram, Zohaib; Hyder, Tahira; Al-Hamoudi, Nawwaf; Binshabaib, Munerah; ALHarthi, Shatha Subhi; Hanif, Atif

doi:10.1016/j.pdpdt.2017.05.007

Cited by 99 publications

(36 citation statements)

References 33 publications

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“…Scaling and root planing (SRP) is the main mechanical treatment (Heitz‐Mayfield & Lang, 2013) with variable success rates attributable to the local factors such as deep probing pocket depths (PPDs) and intra‐bony/furcation defects; in such circumstances, surgery may become mandatory for satisfactory healing (Drisko, 2001). For better SRP outcomes and reducing surgical need, several adjuncts including statins, bisphosphonates, metformin, antimicrobials, delivery systems, lasers and host modulators have been introduced (Abduljabbar et al, 2017; Akram, Abduljabbar, et al, 2017; Akram, Hyder, et al, 2017; Akram, Vohra, & Javed, 2018). At present, however, no adjunct is superior to another; thus, well‐conducted randomized controlled trials (RCTs) are still necessary to understand their value in treatment (Heitz‐Mayfield & Lang, 2013; Mombelli, 2018).…”

Section: Introductionmentioning

confidence: 99%

The effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C‐reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo‐controlled clinical trial

Keçeli

Ercan

Hendek

et al. 2020

J Clinic Periodontology

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Aim: To evaluate clinical and biochemical effects of adjunctive systemic folic acid (FA) intake with scaling and root planing (SRP) in periodontitis treatment. Materials and methods: Sixty periodontitis subjects (30 per group) were randomly assigned into study groups and treated with either SRP + placebo (SRP + P) or SRP + folic acid (SRP + F). In addition to clinical parameters (plaque index [PI], gingival index [GI], probing pocket depth [PPD], clinical attachment level [CAL] and gingival recession [GR]), gingival crevicular fluid (GCF) samples were obtained at baseline and post-treatment (PT) periods (one (PT-1), three (PT-3) and six (PT-6) months) for C-reactive protein (CRP) and homocysteine (Hcy) evaluation.Results: Significant time-dependent reduction was detected at all clinical parameters for both groups (p < .001). Compared to SRP + P, CAL was lower in SRP + F at PT-1 (p = .004) and PT-3 (p = .035), whereas GR was lower at only PT-1 (p = .015). GCF volume and CRP did not show inter-group differences, whereas Hcy was higher in SRP + F at PT-3 (p = .044) and PT-6 (p = .041). GCF volume and Hcy showed reduction after treatment in both groups (p < .001). Conclusion: Both modalities exhibited clinical improvement and change in biochemical parameters. Adjunctive systemic FA intake may be recommended adjunctive to periodontitis treatment to reveal better outcomes. However, its impact mechanisms should be further enlightened. K E Y W O R D S C-reactive protein, folic acid, gingival crevicular fluid, homocysteine, periodontal treatment, periodontitis | 603 KECELI Et aL.

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Section: Introductionmentioning

confidence: 99%

The effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C‐reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo‐controlled clinical trial

Keçeli

Ercan

Hendek

et al. 2020

J Clinic Periodontology

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“…Considering the limitations of SRP, many commercially‐available adjunctives can be helpful in overcoming these shortcomings. Local and systemic antibiotics, photodynamic therapy, locally‐delivered statins, and metformin are some of the suggested adjunctives, among which the most widely used are systemic antibiotics. However, restoring symbiotic bacteria causes a change in the local environment, which could enable SRP to resolve inflammation and prevent further recolonization .…”

Section: Introductionmentioning

confidence: 99%

Effect of local probiotic (Lactobacillus reuteri) vs systemic antibiotic therapy as an adjunct to non‐surgical periodontal treatment in chronic periodontitis

Ikram

Hassan

Baig

et al. 2019

J of Invest & Clin Dent

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Aim The aim of the present study was to assess and compare the clinical efficacy of local probiotic Lactobacillus reuteri (L. reuteri) and systemic antibiotics as adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis (CP). Methods Thirty systemically‐healthy participants (15 probiotic and 15 antibiotic), clinically diagnosed with CP, were enrolled. All patients underwent SRP. Adjunctive probiotics were administered twice daily for 3 months, whereas a combination of amoxicillin and metronidazole were given three times daily for 7 days. Results Intragroup analysis showed statistically‐significant improvement in all clinical parameters: plaque index, bleeding on probing, periodontal pocket depth, and clinical attachment level gain at each follow‐up visit. However, intergroup comparison of clinical periodontal parameters did not show statistical significance. Conclusion The adjunctive use of L. reuteri and systemic antibiotics along with SRP showed similar improvement in all clinical periodontal parameters. This indicates that both adjunctive therapeutic agents showed similar efficacy in resolving inflammation and improving periodontal outcomes.

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“…Low-intensity laser therapy (LILT) in dentistry has been used for longer than half a century and has enabled clinicians to achieve enhanced clinical results in the treatment of several oral diseases, including periodontal diseases, desquamative gingivitis, pigmented lesions, and GR defects. [6][7][8][9][10][11][12][13] Research indicates that LILT produces tissue surface sterilization and minimizes the chances of bacteremia, and decreases edema, swelling, and scarring. 14 In addition, LILT has been shown to successfully biostimulate and accelerate wound healing by stimulating epithelization and regeneration of human and animal tissue.…”

Section: Introductionmentioning

confidence: 99%

Low‐intensity laser for harvesting palatal graft for the treatment of gingival recession: A systematic review

Al‐Shibani

2018

J of Invest & Clin Dent

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The aim of the present study was to assess the efficacy of low‐intensity laser therapy (LILT) for harvesting palatal connective tissue graft (PCTG) in the treatment of gingival recession. Databases were searched up to May 2018. The addressed focused question was: Is adjunctive LILT effective in the healing of donor palatine area after harvesting PCTG? Screening of the initially identified studies resulted in four clinical studies. All studies showed that LILT was effective in improving clinical outcomes, such as tissue thickness, postoperative discomfort, remaining wound area, and visual analog score at follow up. Upon comparison with the control group, two studies showed significantly greater improvements in the clinical parameters and patient‐centered outcomes for LILT than control groups at follow up. Due to the low number of included clinical studies, it remains debatable whether LILT improves clinical and patient‐centered outcomes of PCTG procedures. Further randomized controlled trials are needed to evaluate the outcomes of LILT on the healing of donor palatine area after harvesting PCTG

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Efficacy of photodynamic therapy versus antibiotics as an adjunct to scaling and root planing in the treatment of periodontitis: A systematic review and meta-analysis

Cited by 99 publications

References 33 publications

The effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C‐reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo‐controlled clinical trial

The effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C‐reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo‐controlled clinical trial

Effect of local probiotic (Lactobacillus reuteri) vs systemic antibiotic therapy as an adjunct to non‐surgical periodontal treatment in chronic periodontitis

Low‐intensity laser for harvesting palatal graft for the treatment of gingival recession: A systematic review

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