Efficacy of intrauterine administration of autologous peripheral blood mononuclear cells on the pregnancy outcomes in patients with recurrent implantation failure: A systematic review and meta-analysis

Pourmoghadam, Zahra; Abdolmohammadi-Vahid, Samaneh; Pashazadeh, Fariba; Aghebati‐Maleki, Leili; Ansari, Freshteh; Yousefi, Mehdi

doi:10.1016/j.jri.2019.103077

Cited by 24 publications

(16 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The intrauterine administration of corticotropin-releasing hormone (CRH)-treated autologous PBMCs was also demonstrated to improve clinical pregnancy rates of patients with repeated implantation failure [154]. Currently, the effectiveness of PBMC therapy has been positively reported [155][156][157][158].…”

Section: Topics Of Clinical Application Of Immune Therapymentioning

confidence: 99%

Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems

Fujiwara

Ono

Sato

et al. 2020

IJMS

View full text Add to dashboard Cite

Embryo implantation in the uterus is an essential process for successful pregnancy in mammals. In general, the endocrine system induces sufficient embryo receptivity in the endometrium, where adhesion-promoting molecules increase and adhesion-inhibitory molecules decrease. Although the precise mechanisms remain unknown, it is widely accepted that maternal–embryo communications, including embryonic signals, improve the receptive ability of the sex steroid hormone-primed endometrium. The embryo may utilize repulsive forces produced by an Eph–ephrin system for its timely attachment to and subsequent invasion through the endometrial epithelial layer. Importantly, the embryonic signals are considered to act on maternal immune cells to induce immune tolerance. They also elicit local inflammation that promotes endometrial differentiation and maternal tissue remodeling during embryo implantation and placentation. Additional clarification of the immune control mechanisms by embryonic signals, such as human chorionic gonadotropin, pre-implantation factor, zona pellucida degradation products, and laeverin, will aid in the further development of immunotherapy to minimize implantation failure in the future.

show abstract

Section: Topics Of Clinical Application Of Immune Therapymentioning

confidence: 99%

Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems

Fujiwara

Ono

Sato

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…This meta‐analysis included five studies (ie, two RCTs and three quasi‐experimental studies) involving a total of 570 women in the PBMC group and 516 women in the control group. The authors revealed that immunotherapy results in higher IR ([OR = 1.59; 95% CI 1.04‐2.42; P = .03 in quasi‐experimental studies] and [OR = 2.47; 95% CI 1.31‐4.67; P = .005 in RCTs]), CPR ([OR = 2.03; 95% CI = 1.22‐3.36; P = .006 in quasi‐experimental studies] and [OR = 3.57; 95% CI 1.99‐6.40; P < .0001 in RCTs]), and LBR ([OR = 1.80; 95% CI = 1.05‐3.10; P = .03 in quasi‐experimental studies] and [undetermined in RCTs]) and reduces miscarriage rates (OR = 0.42; 95% CI 0.23‐0.77; P = .005 in RCTs) 40 …”

Section: Discussionmentioning

confidence: 99%

“…The control group of all five studies was formed by patients who did not undergo any intervention. The authors concluded that: “although the involved mechanisms of the therapeutic effects of these cells are not exactly understood, the results of this review and other studies discussed in the previous section confirm that intrauterine administration of autologous PBMCs can improve the implantation, pregnancy, and live birth.” 40 …”

Section: Discussionmentioning

confidence: 99%

Intrauterine perfusion immunotherapies in recurrent implantation failures: Systematic review

Cavalcante

Sarno

et al. 2020

American J Rep Immunol

View full text Add to dashboard Cite

Studies have investigated the gestational outcomes of new immunological therapies in the treatment of patients with recurrent implantation failure (RIF) in assisted reproductive technology (ART). The objective of this article is to assess the current state of evidence available in the literature on intrauterine perfusion immunotherapies in women undergoing ART treatments. By considering the guidelines of Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA), the authors performed systematic review by searching the databases of PubMed/MEDLINE and Scopus using the following key words: “recurrent implantation failure,” “intrauterine infusion,” “Platelet‐Rich Plasma (PRP),” “Peripheral Blood Mononuclear Cells (PBMC),” “Granulocyte Colony‐Stimulating Factor (G‐CSF),” and “Human Chorionic Gonadotropin (hCG).” The authors analyzed the indications and the impact of new immunological therapies with intrauterine infusions on the pregnancy outcomes of patients undergoing ART. PRP, PBMC, G‐CSF, and hCG were the four most used immunological therapies with intrauterine infusion. These new therapies appear to improve the results of ART treatments in cases of RIF. However, the small number of studies does not allow definitive conclusions about the effectiveness of these therapies.

show abstract

“…Recently, an array of meta-analyses has emerged, three referring to infertile populations in general (Maleki-Hajiagha et al, 2019;Yakin et al, 2019;Yang et al, 2020) and one referring to patients with RIF (Pourmoghadam et al, 2020a). Of the meta-analysis, evaluating the method as an intervention for infertility in general, the one that supports a significant benefit to the general infertile population (Maleki-Hajiagha et al, 2019) involves fewer participants than the two that draw a non-significant result (Yakin et al, 2019;Yang et al, 2020).…”

Section: Intra-uterine Administration Of Peripheral Blood Mononuclearmentioning

confidence: 99%

“…Interestingly, subgroup analysis has revealed a significant improvement in reproductive outcomes in women with RIF (Yakin et al, 2019;Yang et al, 2020). The only metaanalysis focused on RIF, having included 1,215 participants, has concluded that intra-uterine administration of PBMC significantly improves the reproductive result in women with RIF (Pourmoghadam et al, 2020a). The results of the meta-analyses, combined, regarding the significantly positive results on RIF, imply a future role for this procedure in treating women with RIF.…”

Section: Intra-uterine Administration Of Peripheral Blood Mononuclearmentioning

confidence: 99%

Approaches to Improve Endometrial Receptivity in Case of Repeated Implantation Failures

Makrigiannakis

Makrygiannakis

Vrekoussis

2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Repeated implantation failures are a constant challenge in reproductive medicine with a significant impact both on health providers and on infertile couples. Several approaches have been proposed so far as effective; however, accumulative data have clarified that most of the treatment options do not have the evidence base for a generalized application to be suggested by the relevant societies. Implantation failures are attributed to either poor quality embryos or to defected endometrial receptivity. The current review aims to summarize in a systematic way all the new trends in managing RIF via interference with endometrial receptivity. The authors focus mainly, but not exclusively, on endometrial injury prior to embryo transfer and endometrial priming with autologous cells or biological agents. To this direction, a systematic search of the Pubmed database has been conducted taking into account the emerged evidence of the last two decades. All the suggested interventions are herein presented and analyzed in terms of reproductive outcomes. It is evident that properly powered and designed randomized trials are needed to support a new standard approach in RIF treatment that will safely be incorporated in national and international guidelines.

show abstract

Efficacy of intrauterine administration of autologous peripheral blood mononuclear cells on the pregnancy outcomes in patients with recurrent implantation failure: A systematic review and meta-analysis

Cited by 24 publications

References 42 publications

Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems

Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems

Intrauterine perfusion immunotherapies in recurrent implantation failures: Systematic review

Approaches to Improve Endometrial Receptivity in Case of Repeated Implantation Failures

Contact Info

Product

Resources

About