Efficacy of Intralesional Corticosteroid Injection in Endoscopic Treatment of Esophageal Strictures

Abstract

Intralesional triamcinolone presented a higher improvement of dysphagia and a lower refractority rate in patients with complex strictures with statistically significant differences.

A prospective randomized trial of intralesional triamcinolone injections after endoscopic dilation for complex esophagogastric anastomotic strictures

“…Different steroids such as betamethasone or dexamethasone have been used intralesionally along with endoscopic dilation in other retrospective series with encouraging results [3,9].…”

“…The technique of dilation (either bougie or balloon) or injections (before or after dilation), as well as the performance of injections varies from only in the first session to as many sessions as the number of dilations [4,5,[9][10][11].…”

Intralesional steroid is beneficial in benign refractory esophageal strictures: A meta-analysis

“…The TNRD was comparable in 5 studies[ 17 , 18 , 19 , 20 , 21 ], where MD was -1.172 in comparison to the dilation alone group (95%CI: -0.238, 0.053; P = 0.057). The studies in this analysis showed no heterogeneity: ( Q = 3.66; df = 4; P = 0.45; I 2 = 0.0%).…”

“…However, the laceration developed in a patient, who continued the anticoagulant therapy during the procedure, and the other 4 patients received adjuvant chemotherapy, which is a risk factor for candidiasis. One perforation occurred in the dilation only group in Orive-Calzada et al[ 20 ] trial, with no complication reported in patients with intralesional steroid injection. Other trials did not report any adverse events in either therapy group.…”

“…The TNRD[ 17 , 18 , 19 , 20 , 21 ] was compared with the method noted above. We found a non-significant ( P = 0.057) improvement in the combined therapy group using the mean difference method.…”