Efficacy of hemithyroidectomy in papillary thyroid carcinoma with minimal extrathyroidal extension

Ji, Yong Bae; Song, Chang Myeon; Kim, Dong Hwan; Sung, Eui Suk; Lee, Jun Young; Chung, Min Sung; Tae, Kyung

doi:10.1007/s00405-019-05598-z

Cited by 15 publications

(17 citation statements)

References 28 publications

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“…Regarding laryngeal nerve injury, TT ± RAI had a higher rate than HT, with an incidence from 0 per cent 21,26 to 1·6 per cent 25 for HT and from 0·6 per cent 23 to 9·4 per cent 25 for TT ± RAI. Permanent hypoparathyroidism was reported in three studies 21,23,26 . Although no patients with hypoparathyroidism were reported following HT, in the TT ± RAI groups the rate ranged from 1·7 per cent 23 ( P < 0·001) to 7·7 per cent 21 .…”

Section: Resultsmentioning

confidence: 91%

“…The initial search resulted in a total of 7203 records. After removal of 2080 duplicates and screening of all titles and abstracts, a total of 68 papers were assessed in full text for inclusion, after which 58 were excluded, resulting in a total of ten studies [18][19][20][21][22][23][24][25][26][27] for analysis ( Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…ranged from 1⋅7 per cent 23 (P < 0⋅001) to 7⋅7 per cent 21 . Finally, one study 26 reported on seroma, with 19 (29 per cent) and 25 (38 per cent) patients in the HT and TT ± RAI groups respectively (P = 0⋅268).…”

Section: Complicationsmentioning

confidence: 96%

“…A total of four studies 20,22,23,25 , involving 12 321 patients, reported on recurrence in patients with PTMC. The pooled recurrence rate after TT ± RAI was 2⋅0 per Hassanain and Wexler 19 Lee et al 20 Kim et al 21 Kim et al 22 Kwon et al 23 Song et al 27 Choi et al 24 Jeon et al 25 Ji et al 26 163 of 5844 A Mantel-Haenszel random-effects model was used for meta-analysis. Odds ratios are shown with 95 per cent confidence intervals.…”

Section: Recurrencementioning

confidence: 99%

“…Complications were reported in four studies 21,23,25,26 ( Table 3). Overall, higher complication rates were found in the TT ± RAI group.…”

Section: Complicationsmentioning

confidence: 99%

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Hemithyroidectomyversustotal thyroidectomy for well differentiated T1–2 N0 thyroid cancer: systematic review and meta-analysis

Schaap¹,

Botti

Otten

et al. 2020

BJS Open

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Background: Evidence for limiting the extent of surgery in patients with low-risk thyroid cancer is lacking. Methods: A systematic search was performed according to the PRISMA and MOOSE guidelines to assess the effect of total thyroidectomy (TT) with or without radioactive iodine (RAI) treatment versus hemithyroidectomy (HT) on recurrence and overall mortality in patients with differentiated (papillary or follicular) T1-2 N0 thyroid cancer. PubMed, Embase and Cochrane databases were searched, and two authors independently assessed the articles. Results: A total of ten eligible articles were identified. All were observational cohort series, representing a total of 23 134 patients, of which 17 699 were available for meta-analysis. Six studies included patients who had TT followed by RAI treatment. The pooled recurrence rate after TT ± RAI and HT was 2⋅3 and 2⋅8 per cent respectively (odds ratio (OR) 1⋅12, 95 per cent c.i. 0⋅82 to 1⋅53; P = 0⋅48). The pooled 20-year overall survival rate after TT ± RAI was 96⋅8 per cent, compared with 97⋅4 per cent for HT (OR 1⋅30, 0⋅71 to 2⋅37; P = 0⋅40). Overall, higher complication rates were found in the TT ± RAI group. Conclusion: Recurrence rates after HT for treatment of well differentiated T1-2 N0 thyroid cancer were similar to those after TT ± RAI, with a lower incidence of treatment-related complications.

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Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Complicationsmentioning

confidence: 96%

Section: Recurrencementioning

confidence: 99%

“…Complications were reported in four studies 21,23,25,26 ( Table 3). Overall, higher complication rates were found in the TT ± RAI group.…”

Section: Complicationsmentioning

confidence: 99%

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Hemithyroidectomyversustotal thyroidectomy for well differentiated T1–2 N0 thyroid cancer: systematic review and meta-analysis

Schaap¹,

Botti

Otten

et al. 2020

BJS Open

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Assessment of Radiofrequency Ablation for Papillary Microcarcinoma of the Thyroid

Dijk

Coerts

Gunput

et al. 2022

JAMA Otolaryngol Head Neck Surg

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IMPORTANCE Papillary microcarcinomas of the thyroid (mPTCs) account for an increasing proportion of thyroid cancers in past decades. The use of radiofrequency ablation (RFA) has been investigated as an alternative to surgery. The effectiveness and safety of RFA has yet to be determined. OBJECTIVE To evaluate the effectiveness and safety of RFA for low-risk mPTC. DATA SOURCES Embase, MEDLINE via Ovid, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and the top 100 references of Google Scholar were searched from inception to May 28, 2021. STUDY SELECTION Articles reporting on adult patients with mPTC treated with RFA were included. Studies that involved patients with pre-ablation lymph node or distant metastases, recurrence of disease, or extrathyroidal extension were excluded. Final article selection was conducted by multiple reviewers based on consensus. The proportion of eligible articles was 1%.DATA EXTRACTION AND SYNTHESIS This meta-analysis was conducted in accordance with the MOOSE guidelines. Random and fixed-effect models were applied to obtain pooled proportions and 95% CIs. MAIN OUTCOMES AND MEASURESThe primary outcome was the complete disappearance rate of mPTC. Secondary outcomes were tumor progression and complications. RESULTSFifteen studies were included in this meta-analysis. A total of 1770 patients (1379 women [77.9%]; mean [SD] age, 45.4 [11.4] years; age range, 42.5-66.0 years) with 1822 tumors were treated with RFA; 49 tumors underwent 1 additional RFA session and 1 tumor underwent 2 additional RFA sessions. Mean (SD) follow-up time was 33.0 (11.4) months (range, 6-131 months). The pooled complete disappearance rate at the end of follow-up was 79% (95% CI, 65%-94%). The overall tumor progression rate was 1.5% (n = 26 patients), local residual mPTC in the ablation area was found in 7 tumors (0.4%), new mPTC in the thyroid was found in 15 patients (0.9%), and 4 patients (0.2%) developed lymph node metastases during follow-up. No distant metastases were detected. Three major complications occurred (2 voice changes lasting >2 months and 1 cardiac arrhythmia). Minor complications were described in 45 patients. CONCLUSIONS AND RELEVANCEThe findings of this systematic review and meta-analysis suggest that RFA is a safe and efficient method to treat selected low-risk mPTCs. Radiofrequency ablation could be envisioned as step-up treatment after local tumor growth under active surveillance for an mPTC or initial treatment in patients with mPTCs with anxiety about active surveillance.

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Hemithyroidectomy or total thyroidectomy for low-risk papillary thyroid cancer?

et al. 2022

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Efficacy of hemithyroidectomy in papillary thyroid carcinoma with minimal extrathyroidal extension

Cited by 15 publications

References 28 publications

Hemithyroidectomyversustotal thyroidectomy for well differentiated T1–2 N0 thyroid cancer: systematic review and meta-analysis

Hemithyroidectomyversustotal thyroidectomy for well differentiated T1–2 N0 thyroid cancer: systematic review and meta-analysis

Assessment of Radiofrequency Ablation for Papillary Microcarcinoma of the Thyroid

Hemithyroidectomy or total thyroidectomy for low-risk papillary thyroid cancer?

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