Efficacy of Ginger (Zingiber officinale) in ameliorating streptozotocin-induced diabetic liver injury in rats: Histological and biochemical studies

Al-Shathly, Mona Ramadan

doi:10.4103/jmau.jmau_16_19

Cited by 26 publications

(20 citation statements)

References 77 publications

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“…Ginger also promoted glucose clearance in insulin-responsive peripheral tissues and augmented insulin release which maintained blood glucose homeostasis. Additionally, ginger can prevent STZ-induced oxidative stress by inhibiting lipid peroxidation and hence protect β cells from the damaging effect of diabetes-induced free radicals ( Alshathly 2019 ). Steamed ginger extract was recently proven to have anti-hyperglycemic efficacy in alloxan-induced type 1 diabetic mice by closing KATP channels in pancreatic β cells and subsequent stimulation of insulin secretion ( Nam et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

p53 Rather Than β-Catenin Mediated the Combined Hypoglycemic Effect of Cinnamomum cassia (L.) and Zingiber officinale Roscoe in the Streptozotocin-Induced Diabetic Model

et al. 2021

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Background: The antioxidant, hypoglycemic, and insulin-enhancing effects of ginger and cinnamon were previously confirmed in experimental and human studies, while the combined effect of ginger and cinnamon was not thoroughly investigated until now.Objectives: This study was designed to assess the antidiabetic effect of combined administration of ginger (Zingiber officinale Roscoe) and cinnamon (Cinnamomum cassia L.) in streptozotocin (STZ)-induced diabetic rats compared to metformin and to explain the mechanism behind this effect.Materials and methods: STZ was utilized to induce diabetes mellitus in male Sprague–Dawley rats. Assessments of fasting blood glucose level (BGL), the total antioxidant capacity (TAC), serum insulin, HOMA-IR, and HOMA–β cells were performed. Pancreatic gene expression of β-catenin and p53 was assessed using RT-PCR. Assessment of histopathological alterations of pancreatic islet cells was performed using routine and immunohistochemical techniques.Results: BGL significantly decreased (p = 0.01), while serum insulin and TAC significantly increased (p < 0.001) in both metformin- and ginger plus cinnamon–treated groups compared to the untreated diabetic group. HOMA–β cell index significantly increased (p = 0.001) in ginger plus cinnamon, indicating their enhancing effect on insulin secretion in diabetic conditions. p53 gene expression was significantly upregulated (p < 0.001), while β-catenin was insignificantly downregulated (p = 0.32) in ginger plus cinnamon–treated groups. Insulin immunoexpression in β cells significantly increased (p = 0.001, p = 0.004) in metformin- and ginger plus cinnamon–treated groups, respectively.Conclusions: The combined administration of ginger and cinnamon has a significant hypoglycemic and antioxidant effect in STZ-induced diabetes mostly through enhancing repair of islet cells mediated via upregulation of pancreatic p53 expression. Therefore, testing this effect in diabetic patients is recommended.

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Section: Discussionmentioning

confidence: 99%

p53 Rather Than β-Catenin Mediated the Combined Hypoglycemic Effect of Cinnamomum cassia (L.) and Zingiber officinale Roscoe in the Streptozotocin-Induced Diabetic Model

et al. 2021

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“…Increased levels of urea and creatinine may lead to renal dysfunction. However, treatment with the different doses of MECG and glibenclamide signi icantly decreased ALP, ALT, AST, total bilirubin, urea and creatinine levels in blood indicates ameliorative effect of MECG on renal dysfunction and hepatocytes in the liver after administration of STZ in the diabetic rats (Alshathly, 2019). Restoration of decreased globulin, total protein, albumin/globulin ratio and albumin by plant extract and glibenclamide could be due to inhibition of proteolytic activity due to improved insulin production (Ali et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

Antidiabetic and Antihyperlipidemic Activities of Methanolic Extract of Leaves of Coccinia grandis in Diabetic Rats

Ramachawolran¹,

Parasuraman²,

Subramaniam³

et al. 2020

ijrps

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Coccinia grandis is a one of the edible plant and its antidiabetic and antihyperlipidemic activities are not well explored. Hence, the present is planned to study the antidiabetic and antihyperlipidemic activities of methanolic extract of Coccinia grandis leaves in streptozotocin-induced diabetic rats. Coccinia grandis leaves was dried under the shade and extracted with methanol. Preliminary phytochemical and pharmacological analysis were conducted using methanolic extract of Coccinia grandis (MECG) leaves. Female Sprague dawley (SD) was used for acute toxicity studies. Female SD was induced with diabetes by administering streptozotocin (55 mg/kg, i.p.). Glibenclamide (20 mg/kg, p.o.) or MECG leaves (125, 250 and 500 mg/kg, p.o.) used to treat diabetic rats for 28 days. Blood samples were collected at regular intervals to check the antidiabetic effect of MECG. On 28th day, blood sample was collected from the rats to analyse biochemical and lipid profile. MECG did not show any toxic symptoms up to the dose 2000 mg/kg/ BW. MECG at 125, 250 and 500 mg/kg marked significant antidiabetic and antihyperlipidemic activities. Coccinia grandis reduced streptozotocin-induced weight loss and significantly recovered lipid levels. At the end of the study, MECG exhibited significant antidiabetic and antihyperlipidemic activities in streptozotocin-induced diabetes in rats.

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“…The antioxidant potency of ginger has been attributed to gingerols preventing ROS production [47]. The increase in antioxidants activities and diminishusion of MDA level were observed in ginger supplemented rats [48][49][50]. The antioxidant effect of N. sativa extract may be due to counteracting the injury generated during diabetes via the free radicals [41], or due to their contents of phenolics and flavonoids that have scavenging effect on the free radicals [13, 43,49].…”

Section: Discussionmentioning

confidence: 99%

Effect of Zingiber officinale and Nigella sativa on Streptozotocin-Diabetic Rats with Reference to Biochemical and Hematological Studies

Ibrahim

Hashem

Mohamed

et al. 2020

Zagazig Veterinary Journal

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This study was aimed to assess the potential ameliorative effect of the ethanolic extract of Zingiber officinale (Z. officinale; ginger) and Nigella sativa (N. sativa; black seed) on streptozotocin (STZ)-diabetic rats. Fifty albino rats of Wistar strain were randomly divided into five equal groups. Group 1 received saline orally (a control group). Groups 2-5 were experimentally exposed to diabetes via intraperitoneal (i.p.) injection of STZ (55 mg/kg BW.). The 2 nd group was left without treatment as diabetic non-treated control, while the 3 rd to 5 th groups were orally treated with metformin (100mg/kg BW), ethanolic extract of ginger (200mg/kg BW.) and N. sativa (300mg/kg BW.), respectively for 21 consecutive days. Blood and pancreatic tissue samples were collected at the end of the experiment for biochemical analysis. The results revealed that blood glucose, fructosamine and insulin levels were improved following treatment by metformin (99.00±4.76, 198.69±5.25 and 29.82±2.35, respectively), and ethanol extract of ginger (105.20±4.87, 317.48±17.79 and13.64±0.72, respectively). Meanwhile, N. sativa extract produced insignificant decrease in glucose level (201.60±14.91) and significant improvement in serum fructosamine and insulin levels (273.20±6.39 and 21.65±1.78) if matched with the diabetic control group on the 3 rd week of the experiment. Treating of diabetic rats with metformin and N. sativa extract elicited a significant increase in blood RBCs count (6.21±0.170 and 5.63±0.135), Hb concentration (12.96±0.229 and 12.00±0.141), PCV% (46.40±1.077 and 74.72±1.085), tissue catalase (0.32 ±0.012 and 0.25±0 .009) and superoxide dismutase activities (19.44±2.16 and 12.77±0.914), respectively when compared with the diabetic group. However, administration with ginger extract produced variable changes in the erythrogram and leukogram. This study provided that Z. officinale and N. sativa extracts have significant effects on some biochemical and hematological assays, as compared with metformin known as standard antidiabetic drug. Consequently, the herbal extracts under current inquiry could have a role in alleviating the risk of some chronic complications of diabetes.

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Efficacy of Ginger (Zingiber officinale) in ameliorating streptozotocin-induced diabetic liver injury in rats: Histological and biochemical studies

Cited by 26 publications

References 77 publications

p53 Rather Than β-Catenin Mediated the Combined Hypoglycemic Effect of Cinnamomum cassia (L.) and Zingiber officinale Roscoe in the Streptozotocin-Induced Diabetic Model

p53 Rather Than β-Catenin Mediated the Combined Hypoglycemic Effect of Cinnamomum cassia (L.) and Zingiber officinale Roscoe in the Streptozotocin-Induced Diabetic Model

Antidiabetic and Antihyperlipidemic Activities of Methanolic Extract of Leaves of Coccinia grandis in Diabetic Rats

Effect of Zingiber officinale and Nigella sativa on Streptozotocin-Diabetic Rats with Reference to Biochemical and Hematological Studies

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