Efficacy of fumagillin against Thelohanellus kitauei infection of Israel carp, Cyprinus carpio nudus

Abstract

The potential of fumagillin dicyclohexylamine salt to treat and prevent intestinal giant-cystic disease in Israel carp, Cyprinus carpio nudus, was monitored in field experimental studies. In experiment 1 (therapeutic), most fish were already naturally infected with more advanced stage of Thelohanellus kitauei. Fumagillin was administered to fish (mean body weight of 830 g) for a period of one month at a dose of 10.62 mg in the first group and 5.3 mg in the second group per fish per day. In experiment 2 (prophylactic), most fish also were already naturally infected with an early developmental stage of the protozoa and fish (average body weight of 484 g) were administered fumagillin for 45 days at a dose of 3.95 mg per fish per day. In both experiments, the cumulative mortalities of fish and the extrusion rates of the polar filaments of the spores were significantly decreased in a dose-independent fashion. In experiment 2 no dead fish were observed. No adverse side effects of the drug were observed among fish from any dosage group. In experiment 2, an oval or dot-like concave lesion of most cysts developed at the 7th day and the vegetative form was never observed at the 17th day postmedication and the cysts were grossly reduced in size as compared with the control group, beginning at the 24th day until the end of the study. In contrast, it was scarcely effective to the cysts in experiment 1.(ABSTRACT TRUNCATED AT 250 WORDS)

Efficacy of fumagillin against haemorrhagic thelohanellosis caused by Thelohanellus hovorkai (Myxosporea: Myxozoa) in coloured carp, Cyprinus carpio L.

“…Fumagillin is an antibiotic which has been reported to be the only efficacious chemotherapeutant against myxosporean diseases ( Molnár, Baska & Székely 1987; Hedrick, Groff, Foley & McDowell 1988; Székely, Molnár & Baska 1988; Wishkovsky, Groff, Lauren, Toth & Hedrick 1990; Yokoyama, Ogawa & Wakabayashi 1990; El‐Matbouli & Hoffmann 1991; Sitja‐Bobadilla & Alvarez‐Pellitero 1992; Rhee, Kim & Park 1993). To date, fumagillin treatment has not yet been practised in aquaculture because there are unresolved problems with toxic residues in the tissues and the withdrawal time of the drug.…”

Molecular Identification and Real-time Quantitative PCR (qPCR) for Rapid Detection of Thelohanellus kitauei, a Myxozoan Parasite Causing Intestinal Giant Cystic Disease in the Israel Carp

“…Only the antibiotic fumagillin has currently been proved as an effective drug for the treatment of IGCD in South Korea by Rhee et al [11]. They pointed out that fumagillin should be administered before the disease develops, as the efficacy of the drug is limited only to the early stages of infection.…”

A Review: Gaps in Our Knowledge on Myxozoan Parasites of Fishes

“…Since the mid-1980s, many researchers have reported successful oral treatments with the fungal anti biotic, fumagillin (Molnar et al, 1987;Hedrick et al, 1988;Szekely et al, 1988;Wishkovsky et al, 1990;Yokoyama et al, 1990;El-Matbouli and Hoffmann, 1991 b; Sitja-Bobadilla and Alvarez-Pellitero, 1992; Rhee et al, 1993;Yokoyama et al, 1999;Wang et al, 2001) and its analog TNP-470 (Higgins and Kent, 1998) against many myxozoan diseases (Table 1), except for ceratomyxosis (Izbarra et al, 1990;Whipple et al, 2002). However, the toxicities of these drugs have lim ited their practical application for farmed fish (Wishkovsky et al, 1990).…”