Efficacy of fluralaner against Otodectes cynotis infestations in dogs and cats

Abstract

BackgroundThe efficacy of fluralaner for the treatment of Otodectes cynotis infestations in dogs and cats was evaluated after oral (dogs) or topical administration (dogs and cats).Twenty-four dogs and sixteen cats were experimentally infested with O. cynotis and randomly allocated to equal sized groups (n = 8/group). Dog groups were treated once, either orally with fluralaner at a minimum dose of 25 mg/kg body weight, topically with fluralaner at a dose of 25 mg/kg body weight or topically with saline solution (control). Cat groups were treated once, either topically with fluralaner at a dose of 40 mg/kg body weight or topically with saline solution. Ears of all animals were examined otoscopically for live visible mites and the amount of debris and cerumen before, and 14 and 28 days after treatment. Twenty-eight days after treatment, animals were sedated and both ears were flushed to obtain the total number of live mites per animal. The efficacy was calculated, based on the results of the ear flushing, by comparing mean live mite counts in the fluralaner treated groups versus the saline solution treated group.ResultsA single topical treatment of cats with fluralaner reduced the mean mite counts by 100% (P < 0.001) at 28 days after treatment. Similarly, a single oral or topical treatment of dogs with fluralaner reduced the mean mite counts by 99.8% (P < 0.001) at 28 days after treatment. Cats treated topically with fluralaner had no mites visible during otoscopic examination at either 14 or 28 days after treatment. All dogs treated orally or topically with fluralaner had no mites visible during otoscopic examination at 28 days after treatment. At 14 days after treatment, only 1–2 mites were visible in three dogs (oral treatment: 2 dogs, topical treatment: 1 dog). All fluralaner-treated animals showed improvement in the amount of cerumen exudation compared with observations performed before treatment. No treatment related adverse events were observed in any dogs or cats enrolled in these studies.ConclusionsIn this study, fluralaner administered topically to cats and orally or topically to dogs was highly effective against Otodectes cynotis mite infestations.

Efficacy of fluralaner plus moxidectin (Bravecto® Plus spot-on solution for cats) against Otodectes cynotis infestations in cats

“…The same methodology as already described by Taenzler et al [ 12 ] was applied to investigate the miticidal efficacy of the fixed combination of fluralaner plus moxidectin for the treatment of Otodectes cynotis infestations after topical application in cats and, therefore, only differences with regards to methods and study set-up described by Taenzler et al [ 12 ] are given below in detail.…”

“…Of the isoxazoline class, sarolaner is the only member in combination with selamectin, which is registered for the treatment of Otodectes mites in cats, with a re-treatment interval of 4 weeks. The efficacy of fluralaner as a single agent, with a 3 months re-treatment interval, against Demodex , Sarcoptes and Otodectes mites in dogs [ 10 – 12 ] and Otodectes mites in cats [ 12 ] has been reported previously.…”

Efficacy of afoxolaner in the flea control in experimentally infested cats

“…In addition, Walther et al (2016) described fluralaner for spot-on administration in cats as a safe formulation, allowing pharmacological associations to be made without the risk of clinical changes. Taenzler et al (2017) also reported that spot-on administration of a fluralaner-based formulation in cats provoked no adverse effects. In the present study, with afoxolaner no adverse effects being observed in any of the animals treated.…”

Efficacy and safety of sarolaner in the treatment of canine ear mite infestation caused by Otodectes cynotis: a non‐inferiority study

“…Both have long residual activity and act systemically covering ectopic infestation . Good treatment results also have been reported for orally administered and systemically active drugs of the isoxazoline class in small‐scale studies with induced infestation with ear mites in dogs . Sarolaner is approved in Europe, in combination with selamectin, for the treatment of O. cynotis infestations in cats …”