Background Oclacitinib is a Janus kinase (JAK) 1 enzyme inhibitor and blocks JAK1-dependent cytokines and is used to control pruritus. Studies available in cats are very limited and as there is a potential role for oclacitinib in the control of pruritus in this specie, the aim of this study was to evaluate the safety and clinical effects of oral oclacitinib maleate in healthy cats. Results Thirty mixed-breed cats weighing from 2.1 to 5.3 kg each were randomly allocated to three treatment groups of 10 animals each. Cats in two groups received oclacitinib at 1 mg/kg or 2 mg/kg q 12 h orally for 28 days. Cats in the third group were given placebo tablets (cornstarch) q 12 h orally for 28 days. Oclacitinib maleate was well tolerated during the study and few adverse events were observed in treated cats. Clinical signs of toxicity were not observed in any animals treated at 1 mg/kg. Gastrointestinal clinical signs observed in the 2 mg/kg group included vomiting in two of the 10 cats and soft stools in two cats. One cat treated with placebo also exhibited soft stools. No significant differences were observed between the groups for hematologic analyses performed during the study. There was a slight increase in neutrophils and monocytes and a decrease in eosinophil mean counts in treated cats. Mean renal and liver enzymes remained normal throughout the entire study. A small, but significant increase in fructosamine levels was observed for both treated groups compared with placebo; however, values remained within the normal reference range. There were no significant difference between treated groups and the placebo group for urine specific gravity, pH, or urine protein to creatinine ratio mean values. Conclusions Oclacitinib maleate was well tolerated by cats at 1 mg/kg and 2 mg/kg and appeared to be safe for this species when administered orally twice daily for 28 days. More studies would be needed to demonstrate if oclacitinib maleate may be a suitable alternative to treat pruritic cats.
Atualmente, novos casos de leishmaniose visceral estão sendo relatados de forma significativa, como uma importante questão de saúde pública. Essa zoonose provocada pelo protozoário Leishmania spp., é transmitida principalmente pelo flebotomíneo Lutzomyia longipalpis acometendo diversas espécies de mamíferos, sendo o cão doméstico o principal mantenedor do agente em áreas urbanas. A inespecificidade de sinais clínicos, associada à elevada casuística na espécie promove difícil controle da transmissão, diagnóstico e tratamento da doença. Assim, objetivou-se avaliar a sintomatologia apresentada por seis cães positivos para leishmaniose visceral, no município de Vassouras. A investigação retrospectiva foi realizada pelo apontamento das informações presentes nas fichas clínicas de cada animal, seguido de análise estatística descritiva. Os sinais clínicos mais relevantes incluíram anemia, hepatomegalia, icterícia e seborreia. As regiões mais acometidas foram membros, coxins, plano nasal e orelhas. A comparação da sintomatologia em diferentes casos auxilia na compreensão da doença, além de agregar possíveis diagnósticos diferenciais, proporcionando melhor qualidade na investigação clínica ao paciente.Palavras-chave: dermatopatias, leishmania spp., zoonose Clinical signs presented by Leishmania positive dogs in the city of Vassouras-RJAbstract. Currently, the scope of areas affected by leishmaniasis has been growing significantly, being an important matter of public and animal health. This zoonotic disease caused by the Protozoan Leishmania spp., is transmitted primarily by the bite of sandflies, affecting various species of mammals, and the domestic dog the main maintainer of the agent in urban areas. The low specificity of clinical signs associated with high assintomatology in species, promote hard transmission control, diagnosis and treatment of this disease. Therefore, the objective of assessing the symptoms presented by six dogs positive for leishmaniasis, in the municipality of Vassouras. The investigation was conducted by the retrospective appointment of the information present in the charts of each animal, followed by descriptive statistical analysis. Relevant symptoms included anaemia, hepatomegaly, jaundice, linfonodomegalia, onychogryphosis, alopecia, crusted lesions, peeling, hyperkeratosis and seborrhea. The regions most affected were members, cushions, nose and ears. The comparison of symptoms in different cases assists in understanding the Contreras et al. 2 PUBVET v.13, n.4, a302, p.1-6, Abr., 2019disease, in addition to add possible differential diagnosis, providing better quality of life for patients.
O mastocitoma é uma das principais neoplasias diagnosticadas em cães, representando 11% das neoplasias malignas nessa espécie. Exibem várias apresentações clínicas, desde nódulos únicos, delimitados, não aderidos e não ulcerados a placas ou massas eritematosas, infiltrativas e ulceradas. O diagnóstico é realizado com anamnese, avaliação clínica, exames citopatológicos realizados a partir de citologia aspirativa (CAAF) e classificados de acordo com a histopatologia em neoplasias de alto grau ou baixo grau de malignidade. O tratamento baseia-se de acordo com a classificação do mastocitoma, a característica clínica do tumor, localização, presença de metástase e tempo de evolução clínica. Objetivou-se relatar um caso de mastocitoma cutâneo disseminado caracterizado como neoplasia de alto grau de malignidade através do exame histopatológico, em um cão da raça Boxer de 7 anos de idade, atendido na clínica veterinária da Universidade Severino Sombra, apresentando tempo de sobrevida atípico quando comparado a outros relatos de mastocitoma de alto grau.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.