Efficacy of florfenicol in the treatment of bacterial infections in halibut, Hippoglossus hippoglossus (L.), larvae

Roiha, Irja Sunde; Samuelsen, Ole Bent; Harboe, Torstein

doi:10.1111/j.1365-2761.2011.01307.x

Cited by 5 publications

(5 citation statements)

References 25 publications

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“…FFC does not carry the risk of inducing drug-related bone marrow suppression or human aplastic anemia (Syriopoulou et al, 1981;Soback et al, 1995). FFC is a broad spectrum antibacterial agent with efficacy against a number of commonly encountered bacteria including many gram-positive and gramnegative bacteria (Ayling et al, 2000;Liu et al, 2003;Shin et al, 2005;Marien et al, 2007;Gilliam et al, 2008;Roiha et al, 2011;Del Pozo Sacristan et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of an in situ forming gel system for sustained delivery of Florfenicol

Liu

et al. 2014

Vet Pharm & Therapeutics

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The objective of this study was to develop an injectable in situ forming gel system based on Poloxamer for sustained release of Florfenicol (FFC). The formulations were prepared containing certain amounts of Poloxamer 407 (P407) and Poloxamer 188 (P188) alone or with hydroxylpropyl methylcellulose (HPMC), sodium carboxymethyl cellulose (CMC-Na), or polyvinyl pyrrolidone (PVP) as polymer additives. The optimal formulation was chosen according to in vitro parameters (gelation temperature, gelation time, pH value, viscosity, and in vitro release). Then the FFC in vivo pharmacokinetic character of the optimal formulation was investigated in dogs with a single dose of 50 mg/kg b.w. under s.c. injection. In vitro release studies, all formulations containing polymer additives had prolonged release time and decreased initial burst to some extent. The optimal formulation containing 0.15% HPMC showed a best sustained release profile for about 128 h with the lowest initial burst in vitro (<40% in 24 h). In vivo, the 20% FFC in situ forming gel provided prolonged drug release time within the therapeutic range for about 100 h, with stable plasma levels and elimination half-life (t1/2λz ) nine times higher than the control formulation. In conclusion, in situ forming gel is an attractive alternative for FFC sustained release system.

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Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of an in situ forming gel system for sustained delivery of Florfenicol

Liu

et al. 2014

Vet Pharm & Therapeutics

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“…FFC is an animal‐specific bacteriostatic antibiotic that derived from chloramphenicol and thiamphenicol, which has a fluorine atom instead of the hydroxyl group located at C‐3 (Cannon et al ., ). Florfenicol is a broad spectrum against many gram‐negative bacteria that inhibits protein synthesis by binding to ribosomal subunits of susceptible bacteria, leading to the inhibition of peptidyl transferase and thereby preventing the transfer of amino acids to growing peptide chains and subsequent protein formation (Cannon et al ., ; Ayling et al ., ; Liu et al ., ; Shin et al ., ; Marien et al ., ; Roiha et al ., ; Del Pozo Sacristan et al ., ). Unlike chloramphenicol and thiamphenicol, florfenicol is not subject to the action of acetyltransferase that bacteria used to develop resistance (Cannon et al ., ; Paape et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Study of pharmacokinetics of an in situ forming gel system for controlled delivery of florfenicol in pigs

Tian

et al. 2015

Vet Pharm & Therapeutics

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To reduce florfenicol (FFC) administration frequency in veterinary use, the drug was currently developed into in situ forming gel. Twelve pigs were randomly divided into two groups (six pigs per group). A single i.m. dose of 40 mg/kg body weight (b.w.) was given to pigs, group one was given FFC in situ forming gel, and group two was given FFC conventional injection. High-performance liquid chromatography (HPLC) was used to determine FFC plasma concentrations. There were significant differences (P < 0.01) between FFC in situ forming gel and conventional injection, in pharmacokinetic parameters MRT (mean retention time) (57.79 ± 2.88) h versus (15.94 ± 1.29) h, AUC (area under the concentration-time curve) (421.54 ± 8.97) μg·h/mL versus (168.16 ± 4.59) μg·h/mL, tmax (time of occurrence of cmax ) (9.00 ± 2.68) h versus (4.33 ± 0.82) h, cmax (maximum plasma concentration) (6.87 ± 0.66) μg/mL versus (12.01 ± 0.66) μg/mL, t1/2λz (terminal elimination half-life) (38.04 ± 2.20) h versus (9.15 ± 2.71) h. The results demonstrated that the in situ forming gel system could shorten dosing interval of FFC and thus achieved less frequent administration during long-term treatment.

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“…s almonicida, A. salmonicida ssp. a chromogenes , Flexibacter ovolyticus and Vibrio (Listonella) anguillarum (Bergh et al., ; Björnsdóttir, Smáradóttir, Sigurgísladóttir, & Guðmundsdóttir, ; Roiha, Samuelsen, & Harboe, ). It has previously been shown that juvenile and adult halibut are susceptible to A. salmonicida ssp.…”

Section: Introductionmentioning

confidence: 99%

“…The principle bacterial pathogens of larval, juvenile and adult halibut are the following: Aeromonas salmonicida ssp. salmonicida, Harboe, 2011). It has previously been shown that juvenile and adult halibut are susceptible to A. salmonicida ssp.…”

Section: Introductionmentioning

confidence: 99%

Comparative pathogenicity of Vibrio spp., Photobacterium damselae ssp. damselae and five isolates of Aeromonas salmonicida ssp. achromogenes in juvenile Atlantic halibut (Hippoglossus hippoglossus)

Bowden

Bricknell

Preziosi

2017

Journal of Fish Diseases

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Juvenile Atlantic halibut (~100 mg, Hippoglossus hippoglossus) were exposed to Vibrio proteolyticus, a Vibrio spp. isolate, Photobacterium damselae ssp. damselae and five different isolates of Aeromonas salmonicida ssp. achromogenes via an hour‐long bath immersion to ascertain their variation in pathogenicity to this fish species. Results were analysed using Kaplan–Meier survival analysis. Analysis of the data from challenges using A. salmonicida ssp. achromogenes revealed three survival values of zero and a spread of values from 0 to 28.43. Challenges using a Vibrio spp isolate, V. proteolyticus and P. damselae resulted in Kaplan–Meier survival estimates of 31.21, 50.41 and 57.21, respectively. As all bacterial species tested could induce juvenile halibut mortalities, they must all be considered as potential pathogens. However, the degree of pathogenicity of A. salmonicida is isolate dependent.

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Efficacy of florfenicol in the treatment of bacterial infections in halibut, Hippoglossus hippoglossus (L.), larvae

Cited by 5 publications

References 25 publications

In vitro and in vivo evaluation of an in situ forming gel system for sustained delivery of Florfenicol

In vitro and in vivo evaluation of an in situ forming gel system for sustained delivery of Florfenicol

Study of pharmacokinetics of an in situ forming gel system for controlled delivery of florfenicol in pigs

Comparative pathogenicity of Vibrio spp., Photobacterium damselae ssp. damselae and five isolates of Aeromonas salmonicida ssp. achromogenes in juvenile Atlantic halibut (Hippoglossus hippoglossus)

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