Efficacy of Defibrinogenation and Steroid Therapies on Sudden Deafness

Kubo, Takeshi; Matsunaga, Toru; Asai, Hideaki; Kawamoto, Kazuyuki; Kusakari, Jun; Nomura, Yasuya; Oda, Makoto; Yanagita, Noriyuki; Niwa, Hideto; T, Uemura

doi:10.1001/archotol.1988.01860180063031

Cited by 61 publications

(45 citation statements)

References 10 publications

(1 reference statement)

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“…The reason why the dextran 40 treatment seemed to fail [70] can be that dextran 40 has such a short half-life that the hemodilution is too shortacting always followed by a hemoconcentration phase. Another option is that the placebo treatment, which consisted of saline infusion, might also have had a therapeutic effect.…”

Section: Discussionmentioning

confidence: 99%

Sudden Deafness – A Critical Evaluation of Pathogenesis and ‘Cure’

Hultcrantz¹

1999

Otorhinolaryngol Nova

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Objective: To discuss the possible etiology, pathogenesis and ‘cure’ of idiopathic sudden deafness (SD). Method: A review was made of different methods for the study of inner-ear physiology, especially its microcirculation, relating them to clinical evaluation and praxis for SD. Results: Cochlear blood flow (CBF) can be measured quantitatively with the microsphere method in animals. Direct qualitative measurements can be performed using the laser Doppler method. The CBF is partly autoregulated, but to a lesser degree than cerebral blood flow. Sympathetic stimulation decreases CBF up to 25%. Noise does not influence total CBF but seems to reduce blood flow in the lateral wall. Nicotinic acid, hemodilution and osmotic drugs increase the CBF proportionally. Carbogen increases the CBF but also creates acidosis. Treating patients with SD in accordance with these findings does not show any convincing effect compared to no treatment. Conclusion: More and more diseases have been identified which can have SD as a symptom. It is important to investigate to identify these treatable cases. Idiopathic cases should not be exposed to hazardous systemic medication or surgery. Local treatment through the round window will be the treatment modality for the future, but more basic research is necessary.

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Section: Discussionmentioning

confidence: 99%

Sudden Deafness – A Critical Evaluation of Pathogenesis and ‘Cure’

Hultcrantz¹

1999

Otorhinolaryngol Nova

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“…Spontaneous recovery may occur in patients with a slight degree, and no improvement can be expected in patients with profound hearing loss [17,18], All authors agree that, although ISHL appears to have a chance of spontaneous recovery during the first 2 weeks, sponta neous recovery is unlikely after 3 months. Treatment then is extremely difficult [2,7,17,18].…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Sudden Hearing Loss and Disturbance of Iron Metabolism

Sun¹,

Wang

Xiao³

et al. 1992

ORL

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The role of disturbances of the iron metabolism (DIM) in idiopathic sudden hearing loss (ISHL) was investigated in 426 patients with ISHL who received iron therapy, anti-DIM medication, vitamins, and a combined regimen in a randomized study which was stratified by stages and groups. Low concentrations of haemoglobin, serum iron, serum ferritin, and red cell basic ferritin as well as abnormal circadian variations in the serum iron level were observed. The results were significantly better in patients receiving iron therapy than in those receiving anti-DIM medication, vitamins, and the combined regimen. Hearing improvement was achieved in 53.26% of the patients whose treatment started later than 3 months after the onset of the disease. The clinical association of DIM and ISHL is discussed.

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“…Effects of defibrinogenation therapy and steroid therapy were compared by a randomized, paired, double-blind method. The improvement rate in cases in which hearing recovered more than 30 dB -the marked recovery group by the Japanese standards -was significantly better in the defibrinogenation group [14]. In a nonrandomized control study of ·-interferon, an antiviral agent, complete recovery was found in 27 patients (64.3%) among 42 patients with the average hearing over 70 dB; this suggested the effectiveness of this drug [15].…”

Section: Efficacy Of Treatmentmentioning

confidence: 94%