Efficacy of Combination Therapy of Statin and Vitamin C in Comparison with Statin in the Prevention of Post-CABG Atrial Fibrillation

Samadikhah, Jahanbakhsh; Golzari, Samad Ej; Sabermarouf, Babak; karimzadeh, Ida; Tizro, Parastou; Khanli, Hadi Mohammad; Ghabili, Kamyar

doi:10.5681/apb.2014.015

Cited by 9 publications

(1 citation statement)

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“…An additive beneficial effect with regards to the reduction of postoperative arrhythmias was observed with simultaneous supplementation of vitamin C and b-blockers 83 , 87 , 91 , while Samadikhah et al . 93 reported the same beneficial effect for the combination of atorvastatin plus vitamin C, than single oral atorvastatin.…”

Section: Resultsmentioning

confidence: 86%

Preoperative and postoperative administration of vitamin C in cardiac surgery patients – settings, dosages, duration, and clinical outcomes: a narrative review

Athanasiou,

Charalambous,

Anastasiou

et al. 2024

Annals of Medicine &Amp; Surgery

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Vitamin C or ascorbic acid is a water-soluble vitamin capable of directly donating electrons to reactive oxygen species, attenuating electrical remodeling, and cardiac dysfunction in patients undergoing cardiac surgery (CS), considered one of the most effective defenses against free radicals in the blood, thus being one of the first antioxidants consumed during oxidative stress. The aim of this review is to assess the effects of perioperative administration of vitamin C in CS patients. A comprehensive literature search was conducted in order to identify prospective cohort studies and/or randomized controlled trials reporting on the perioperative effects of vitamin C among adult patients undergoing CS. Studies published between January 1980 to December 2022 were included in our search, resulting in a total of 31 articles that met all our inclusion criteria. There seems to be a beneficial effect of vitamin C supplementation in arrhythmias such as in postoperative atrial fibrillation, reduction of ICU length of stay, and hospital length of stay, reduction in postoperative ventilation time, in inotropic demand, and in postoperative fatigue. Vitamin C can act as a scavenger of free radicals to decrease the peroxidation of the lipids present in the cell membrane, and to protect the myocardium postoperatively from ischemia/reperfusion injury, thus attenuating oxidative stress and inflammation. It represents a readily available and cost-effective strategy that could improve the outcome of patients undergoing CS, by reducing the risk of serious cardiovascular adverse events, both perioperatively and postoperatively.

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Section: Resultsmentioning

confidence: 86%