Efficacy of Chamomile in the Treatment of Premenstrual Syndrome: A Systematic Review

Khalesi, Zahra Bostani; Beiranvand, Siavash; Bokaie, Mahshid

doi:10.3831/kpi.2019.22.028

Cited by 18 publications

(22 citation statements)

References 19 publications

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“…Additionally, clinical studies demonstrated that M. chamomilla could exhibit an interesting analgesic effect on women during childbirth [182,183]. The plant was also efficient in relieving the pain of mild to moderate mastalgia, breast pain often preceding the menstrual period [184]. In addition, some reviews gathered studies on the use of M. chamomilla in the treatment of premenstrual syndrome [185], primary dysmenorrhea, and reducing menstrual bleeding [186].…”

Section: Phyotherapeutical Applicationsmentioning

confidence: 99%

Chamomile (Matricaria chamomilla L.): A Review of Ethnomedicinal Use, Phytochemistry and Pharmacological Uses

Mihyaoui

Silva

Charfi

et al. 2022

Life

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Matricaria chamomilla L. is a famous medicinal plant distributed worldwide. It is widely used in traditional medicine to treat all kinds of diseases, including infections, neuropsychiatric, respiratory, gastrointestinal, and liver disorders. It is also used as a sedative, antispasmodic, antiseptic, and antiemetic. In this review, reports on M. chamomilla taxonomy, botanical and ecology description, ethnomedicinal uses, phytochemistry, biological and pharmacological properties, possible application in different industries, and encapsulation were critically gathered and summarized. Scientific search engines such as Web of Science, PubMed, Wiley Online, SpringerLink, ScienceDirect, Scopus, and Google Scholar were used to gather data on M. chamomilla. The phytochemistry composition of essential oils and extracts of M. chamomilla has been widely analyzed, showing that the plant contains over 120 constituents. Essential oils are generally composed of terpenoids, such as α-bisabolol and its oxides A and B, bisabolone oxide A, chamazulene, and β-farnesene, among other compounds. On the other hand, M. chamomilla extracts were dominated by phenolic compounds, including phenolic acids, flavonoids, and coumarins. In addition, M. chamomilla demonstrated several biological properties such as antioxidant, antibacterial, antifungal, anti-parasitic, insecticidal, anti-diabetic, anti-cancer, and anti-inflammatory effects. These activities allow the application of M. chamomilla in the medicinal and veterinary field, food preservation, phytosanitary control, and as a surfactant and anti-corrosive agent. Finally, the encapsulation of M. chamomilla essential oils or extracts allows the enhancement of its biological activities and improvement of its applications. According to the findings, the pharmacological activities of M. chamomilla confirm its traditional uses. Indeed, M. chamomilla essential oils and extracts showed interesting antioxidant, antibacterial, antifungal, anticancer, antidiabetic, antiparasitic, anti-inflammatory, anti-depressant, anti-pyretic, anti-allergic, and analgesic activities. Moreover, the most important application of M. chamomilla was in the medicinal field on animals and humans.

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Section: Phyotherapeutical Applicationsmentioning

confidence: 99%

Chamomile (Matricaria chamomilla L.): A Review of Ethnomedicinal Use, Phytochemistry and Pharmacological Uses

Mihyaoui

Silva

Charfi

et al. 2022

Life

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“…The diagnostic criteria of the PMS for affective symptoms and somatic symptoms must be experienced during the five days before menses in three prior menstrual cycles and relieved with the menstrual flow [ 7 ]. The primary psychological range of PMS is anxiety and depression [ 6 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Oxidative stress is higher in women who experience PMS as per the previous research [ 5 ]. Consequently, as an etiology is unclear, several possible treatments are prescribed and purchased [ 8 ]. Various therapeutic interventions have been scientifically confirmed helpful in PMS ranging from nonpharmacological management (cognitive behavioral therapy, lifestyle modification and diet, education, exercise, and complementary and herbal medications) to pharmacotherapy hormonal therapy (gonadotropin-releasing hormone (GnRH) agonists OCP, etc.)…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the majority of women are turning towards complementary and alternative medicines to treat their symptoms. Many Unani herbs have been anticipated to alleviate PMS as they are a potentially effective natural alternative for PMS symptoms [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…They also designed a study related to herbal medicine and acupuncture for PMS in 2014 [ 21 ]. The other researchers conducted a study on the Chamomile single herb [ 8 ] and exercises for PMS [ 22 ]. However, a recent update on the systematic review of RCTs on herbal medicine and nutritional supplements alleviating PMS as per the modified Jadad scale was not available to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%

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Role of Inflammation, Oxidative Stress, and Mitochondrial Changes in Premenstrual Psychosomatic Behavioral Symptoms with Anti-Inflammatory, Antioxidant Herbs, and Nutritional Supplements

Sultana

Rahman

Heyat

et al. 2022

Oxidative Medicine and Cellular Longevity

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Premenstrual syndrome (PMS) significantly lowers the quality of life and impairs personal and social relationships in reproductive-age women. Some recommendations are that inappropriate oxidative stress and inflammatory response are involved in PMS. Various nutritional supplements and herbs showed neuro-psycho-pharmacological activity with antioxidant and anti-inflammatory properties. This study aims to determine the systematic review of randomized controlled trials (RCTs) of herbal medicine and nutritional supplements in PMS. We also comprehensively highlighted the role of oxidative stress, inflammation, and mitochondrial changes on PMS with the application of computational intelligence. We used PRISMA and research question-based techniques to collect the data for evaluation of our study on different databases such as Scopus, PubMed, and PROSPERO from 1990 to 2022. The methodological quality of the published study was assessed by the modified Jadad scale. In addition, we used network visualization and word cloud techniques to find the closest terms of the study based on previous publications. While we also used computational intelligence techniques to give the idea for the classification of experimental data from PMS. We found 25 randomized controlled studies with 1949 participants ( mean ± SD : 77.96 ± 22.753 ) using the PRISMA technique, and all were high-quality studies. We also extracted the closest terms related to our study using network visualization techniques. This work has revealed the future direction and research gap on the role of oxidative stress and inflammation in PMS. In vitro and in vivo studies showed that bioactive molecules such as curcumin, allicin, anethole, thymoquinone, cyanidin 3-glucoside, gamma-linoleic acid, and various molecules not only have antioxidant and anti-inflammatory properties but also other various activities such as GABA-A receptor agonist, serotonergic, antidepressant, sedative, and analgesic. Traditional Unani Herbal medicine and nutritional supplements can effectively relieve PMS symptoms as they possess many bioactive molecules that are pharmacologically proven for the aforementioned properties. Hence, these biomolecules might influence a complex physical and psychological disease process like PMS. However, more rigorous research studies are recommended for in-depth knowledge of the efficacy of bioactive molecules on premenstrual syndrome in clinical trials.

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Efficacy and Safety of Ganyushu Granule in Treatment of Premenstrual Syndrome with Gan (Liver) Depression and Qi Stagnation Syndrome: A Randomized, Double-Blind, Multi-Center, Phase-II Clinical Trial

Teng,

Xu,

Lin

et al. 2024

Chin. J. Integr. Med.

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Efficacy of Chamomile in the Treatment of Premenstrual Syndrome: A Systematic Review

Abstract: Premenstrual syndrome (PMS) encompasses a vast array of physical and psychological symptoms. Of the herbal supplements mentioned for remedy PMS symptoms, chamomile used as an effective herbal medicine.

Cited by 18 publications

References 19 publications

Chamomile (Matricaria chamomilla L.): A Review of Ethnomedicinal Use, Phytochemistry and Pharmacological Uses

Chamomile (Matricaria chamomilla L.): A Review of Ethnomedicinal Use, Phytochemistry and Pharmacological Uses

Role of Inflammation, Oxidative Stress, and Mitochondrial Changes in Premenstrual Psychosomatic Behavioral Symptoms with Anti-Inflammatory, Antioxidant Herbs, and Nutritional Supplements

Efficacy and Safety of Ganyushu Granule in Treatment of Premenstrual Syndrome with Gan (Liver) Depression and Qi Stagnation Syndrome: A Randomized, Double-Blind, Multi-Center, Phase-II Clinical Trial

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