Chamomile (Matricaria chamomilla L.): A Review of Ethnomedicinal Use, Phytochemistry and Pharmacological Uses

Mihyaoui, Amina El; Silva, Joaquim C. G. Esteves da; Charfi, Saoulajan; Castillo, María Emilia Candela; Lamarti, Ahmed; Arnao, Marino B.

doi:10.3390/life12040479

Cited by 68 publications

(28 citation statements)

References 189 publications

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“…The composition of the EOs is diverse, depending on the plant species and chemo-types, which vary according to geographical and genetic parameters (chemical polymorphism) [ 35 ]. The bioactive compounds of EOs are terpenes and terpenoids, mainly mono-terpenoids (90%) and, in a small percentage, sesqui-, di- and triterpenoids; as very minority components appear some phenylpropanoids (see Table 1 ) and others (amino acids, polyketides, and sulfur compounds).…”

Section: Essential Oilsmentioning

confidence: 99%

Essential Oils and Melatonin as Functional Ingredients in Dogs

Ruiz-Cano¹,

Sánchez-Carrasco²,

Mihyaoui

et al. 2022

Animals

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The use of nutraceuticals or functional ingredients is increasingly widespread in human food; their use is also widespread in animal feed. These natural compounds generally come from plant materials and comprise a wide range of substances of a very diverse chemical nature. In animals, these compounds, so-called phytogenics, are used to obtain improvements in feed production/stability and also as functional components with repercussions on animal health. Along with polyphenols, isoprenoid compounds represent a family of substances with wide applications in therapy and pet nutrition. Essential oils (EOs) are a group of complex substances with fat-soluble nature that are widely used. Melatonin is an indolic amine present in all living with amphiphilic nature. In this work, we present a review of the most relevant phytogenics (polyphenol, isoprenoid, and alkaloid compounds), their characteristics, and possible uses as nutraceuticals in dogs, with special emphasis on EOs and their regulatory aspects, applied in foods and topically. Additionally, a presentation of the importance of the use of melatonin in dogs is developed, giving physiological and practical aspects about its use in dog feeding and also in topical application, with examples and future projections. This review points to the combination of EOs and melatonin in food supplements and in the topical application as an innovative product and shows excellent perspectives aimed at addressing dysfunctions in pets, such as the treatment of stress and anxiety, sleep disorders, alopecia, and hair growth problems, among others.

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Section: Essential Oilsmentioning

confidence: 99%

Essential Oils and Melatonin as Functional Ingredients in Dogs

Ruiz-Cano¹,

Sánchez-Carrasco²,

Mihyaoui

et al. 2022

Animals

Self Cite

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“…These bioactivities are attributed to the phytochemical components of relevant species [45][46][47]. For example, the chemical composition of Matricaria aurea of Asteraceae is dominated by terpenoids and phenolic compounds, phenolic acid, flavonoids, and coumarins [48]. Another example of Asteraceae is Dittrichia viscosa which is rich in sesquiterpenes, flavonoids, and caffeic acids among others [49].…”

Section: Ethnobotanical Diversitymentioning

confidence: 99%

Ethnobotanical survey of medicinal wild plants in the Shouf Biosphere Reserve, Lebanon

Hani

Baydoun

Nasser

et al. 2022

J Ethnobiology Ethnomedicine

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Background Medicinal plants and associated traditional knowledge play a vital role in supporting the livelihoods and resilience of indigenous communities. This ethnobotanical survey aims to identify medicinal plants used by the local communities of the Shouf Biosphere Reserve of Lebanon (SBR) and document the associated traditional knowledge. Methodology Focus groups and personal interviews with 133 informants of community members of 22 villages of SBR were performed during 2019–2022. Informants were selected using purposive sampling techniques based on their knowledge of medicinal plants and experience in traditional herbal medicine. Interviews were conducted using a semi-structured questionnaire through field visits. Results Informants were equally represented by females and males and had different demographic characteristics, and the main source of knowledge was ancestral. A total of 184 medicinal plant species belonging to 57 families were documented. The predominant families were Asteraceae (31 spp.), Lamiaceae (14 spp.), and Rosaceae (14 spp.). Leaves (23%) were the plant part most used. Decoction (45%) was the predominant preparation method, while internal (oral) use (47%) was the most frequent administration mean. Berberis libanotica, Dittrichia viscosa, and Daucus carota achieved the highest scores of frequency of citation (FC), relative frequency of citation (RFC), use value (UV), and fidelity level (FL). Furthermore, diseases and ailments of gastrointestinal tract were the category most treated. Conclusions Findings revealed a rich and diverse list of medicinal plants with associated traditional knowledge still actively used to treat a wide range of diseases. Future phytochemical and pharmacological studies are recommended to determine the efficacy and safety of plant species used. The management body of the SBR and all related authorities are invited to continue their conservation efforts to protect such rich biocultural heritage.

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“…The experimental studies focused on the use of natural compounds in the plant extract and finding the therapies for relieving neurodegenerative diseases including epileptic convulsions (6). MC belongs to the Asteraceae family and is widely grown all around the world (7). The dried flower parts of the plant are largely used in traditional medicine to treat different kinds of diseases, including neurodegenerative, gastrointestinal, cardiovascular and skin diseases (8).…”

Section: Introductionmentioning

confidence: 99%

The effects of crude alkaloid extract of Matricaria chamomilla L. on convulsions induced by pentylenetetrazole in chicks

Suleiman¹,

Hassan²

2022

Bas.J.Vet.Res.

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The present research was designed to evaluate the protective effect of crude alkaloid extract of Matricaria chamomilla L. (MC) against pentylenetetrazole (PTZ) induced convulsions in chicks. A total of seventy-two chicks were randomly divided into six groups each one consisting of 12 chicks. The first group was considered to be a negative group that received subcutaneous injection of normal saline, the second group (positive control) received subcutaneous injection of PTZ (90 mg/kg), and the third group received sodium valproate (200 mg/kg) orally for six days. The other groups (fourth, fifth and sixth) were treated with single intraperitoneal injection of crude alkaloids extract of MC (20, 40, 80 mg/kg) respectively. After 30 minutes of the treatment, the groups (third to sixth) received PTZ and observed the convulsion signs for the next 30 minutes. At the end of the experiment, various biochemical parameters were assessed including, brain gamma-aminobutyric acid (GABA) and glutamate, serum catalase (CAT), glutathione reductase (GR), malondialdehyde (MDA), and 8-isoprostane, and some electrolytes (potassium K + , sodium Na + , chloride Cl -, ionized calcium iCa 2+ , total calcium TCa 2+ ), pH, and glucose levels in serum. The results indicated that the group treated with crude alkaloids extract at higher dose (80 mg/kg) showed a significant increase in CAT and significantly decreased in 8-isoprostane, and an increase in Na + ions concentration in serum. It was concluded that pretreatment of crude alkaloids extract (80 mg/kg) of MC offers anticonvulsant activity by reducing the mortality rate induced by PTZ, as well as it plays an important role in inhibiting oxidative stress.

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Chamomile (Matricaria chamomilla L.): A Review of Ethnomedicinal Use, Phytochemistry and Pharmacological Uses

Cited by 68 publications

References 189 publications

Essential Oils and Melatonin as Functional Ingredients in Dogs

Essential Oils and Melatonin as Functional Ingredients in Dogs

Ethnobotanical survey of medicinal wild plants in the Shouf Biosphere Reserve, Lebanon

The effects of crude alkaloid extract of Matricaria chamomilla L. on convulsions induced by pentylenetetrazole in chicks

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