Efficacy of a platelet-rich plasma injection for the treatment of proximal hamstring tendinopathy: A pilot study

Levy, Gavin M.; Lucas, Phil; Hope, Nigel

doi:10.1016/j.jsams.2018.08.001

Cited by 28 publications

(23 citation statements)

References 27 publications

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“…This study indicates that the addition of PRP did not affect the improvement compared to administration of insulin without PRP. The results of the conclusions are the same as Levy et al (2018), who used PRP in patients who had problems with the tendon. But the results of this study are different from studies using PRP to repair damage to the ovaries and testes.…”

Section: Igf-1 Mrna Expression In Testicular Ratssupporting

confidence: 55%

Effect of Platelet-rich Plasma on Caspase-3 and IGF-1 mRNA expression in the diabetic rat testis

Istiqamah

Rizal

Puspitasari

2019

Indonesian J. Pharm.

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Testicular damage is a serious complication of diabetes mellitus resulting in male infertility, which is associated with caspase-3 and IGF-1 mRNA expression. Platelet-rich plasma (PRP), with its rich growth factor composition, has proven beneficial in regenerative therapy. It is believed that PRP has not been studied in testes for complication of diabetes mellitus and there are no studies in the literature concerning the influence of PRP on expressions of growth factors in diabetic rat testis. The aim of this study was to investigate the efficacy of adjunctive PRP in insulin treatment for repair of testicular damage in a diabetic rat model. Diabetes was induced by administering single dose 60mg/kg streptozotocin. Twenty Wistar male rats were divided into four groups: group 1, control group; group 2, diabetes without treatment; group 3, diabetes with treated insulin; and group 4, diabetes with treated insulin and PRP. Rats were euthanized after two weeks of treatment, and testes were taken for caspase-3 and IGF-1 mRNA expression measurements. Diabetes mellitus induction caused a significant increase in caspase-3 mRNA expression with p=0.049 and significant decrease in IGF-1 mRNA expression with p=0.004. There was no difference in caspase-3 and IGF-1 mRNA expression of the diabetic rat testis given insulin and PRP compared to without PRP.

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Section: Igf-1 Mrna Expression In Testicular Ratssupporting

confidence: 55%

Effect of Platelet-rich Plasma on Caspase-3 and IGF-1 mRNA expression in the diabetic rat testis

Istiqamah

Rizal

Puspitasari

2019

Indonesian J. Pharm.

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“…There was no mention of post-PRP rehabilitation programs in several reported non-Achilles tendon PRP studies (e.g., common extensor tendinopathy) (186) (187). The lack of such programs could be of concern if physicians do not fully appreciate rehabilitation programs as an integral part of a clinical regenerative (tendon) treatment protocol, even though physical or occupational therapy is a commonly prescribed treatment option in patients suffering from tendinopathy.…”

Section: Combining Prp With Rehabilitationmentioning

confidence: 99%

Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020

Everts¹,

Onishi²,

Jayaram³

et al. 2020

Preprint

155

120

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Emerging autologous cellular therapies that utilize platelet-rich plasma (PRP) applications have the potential to play adjunctive roles in a variety of regenerative medicine treatment plans. There is a global unmet need for tissue repair strategies to treat musculoskeletal (MSK) and spinal disorders, osteoarthritis (OA), and patients with chronic complex and recalcitrant wounds. PRP therapy is based on the fact that platelet growth factors (PGFs) support the three phases of wound healing and repair cascade (inflammation, proliferation, remodeling). Many different PRP formulations have been evaluated, originating from human, in vitro, and animal studies. However, recommendations from in vitro and animal research often lead to different clinical outcomes because it is difficult to translate non-clinical study outcomes and methodology recommendations to human clinical treatment protocols. In recent years, progress has been made in understanding PRP technology and the concepts for bioformulation, and new research directives and new indications have been suggested. In this review, we will discuss recent developments regarding PRP preparation and composition regarding platelet dosing, leukocyte activities concerning innate and adaptive immunomodulation, serotonin (5-HT) effects and pain killing. Furthermore, we discuss PRP mechanisms related to inflammation and angiogenesis in tissue repair and regenerative processes. Lastly, we will review the effect of certain drugs on PRP activity, and the combination of PRP and rehabilitation protocols.

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“…Due to a small sample size, the authors of the study could not conclusively determine the efficacy of either whole blood injection or PRP for recalcitrant PHT. Levy et al 72 conducted a retrospective case series, including 29 patients with PHT with mild-to-severe tendinopathy who received one ultrasound-guided leukocyte-poor PRP injection. This study used a validated proximal hamstring-specific functional outcome measure, the Victorian Institute Sport Assessment-Proximal Hamstring Tendons (VISA-H) questionnaire.…”

Section: Prp For Proximal Hamstring Tendinopathymentioning

confidence: 99%

“…At 8-week follow-up, there was no significant improvement in VISA-H compared to baseline, and no significant difference in outcome across severity of tendinopathy. 72 A number of additional small case series have been published that suggest PRP may be useful for the management of PHT (Table 3). Fader et al 73 reported that 10 of 18 patients had 80% or greater improvement in pain scores (mean subjective improvement 63%) at 6 months after single PRP injection.…”

Section: Prp For Proximal Hamstring Tendinopathymentioning

confidence: 99%

“…Levy et al conducted a retrospective case series, including 29 patients with PHT with mild‐to‐severe tendinopathy who received one ultrasound‐guided leukocyte‐poor PRP injection. This study used a validated proximal hamstring‐specific functional outcome measure, the Victorian Institute Sport Assessment‐Proximal Hamstring Tendons (VISA‐H) questionnaire .…”

Section: Prp For Proximal Hamstring Tendinopathymentioning

confidence: 99%

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Orthobiologics for the Hip Region: A Narrative Review

McInnis

Chen

Finnoff

et al. 2020

PM&R

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Management of hip region disorders is challenging. Orthobiologic treatments including platelet rich plasma (PRP), mesenchymal stem cells, and amniotic injectables have gained popularity as promising treatments despite a lack of robust evidence for their effectiveness. We review rationale and current evidence for orthobiologics for three common hip region conditions: hip osteoarthritis, gluteal tendinopathy, and proximal hamstring tendinopathy. Overall, the current state of evidence is extremely limited for orthobiologic treatments and is predominantly relevant to PRP injections. There is currently a lack of data to support the use of mesenchymal stem cells or amniotic injectables in these conditions of the hip. the use of orthobiologics in the treatment of three common diagnoses affecting the hip region: osteoarthritis (OA), gluteal tendinopathy, and proximal hamstring tendinopathy (PHT). Methods A review was conducted of PubMed and Medline articles from January 2000 to June 2019 with search terms including hip, osteoarthritis, gluteal tendonitis, hamstring tendonitis, tendinosis, tendinopathy, platelet rich plasma, mesenchymal stem cell, amniotic stem cell, and amniotic injectables. Randomized controlled trials, case series, systematic reviews, and meta-analyses were reviewed. Only studies investigating chronic refractory tendinopathy and osteoarthritis were included. We did not include studies investigating acute muscle, myotendinous injury, acetabular labral pathology, or focal osteochondral lesion. Platelet Rich Plasma PRP is an autologous plasma concentrate containing platelets above physiologic concentrations in whole blood. Platelets are thought to initiate the healing cascade by forming a fibrin matrix, which serves as a tissue

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Efficacy of a platelet-rich plasma injection for the treatment of proximal hamstring tendinopathy: A pilot study

Abstract: Patients with PHT receiving a PRP injection did not improve on clinical outcomes at 8-weeks follow-up.

Cited by 28 publications

References 27 publications

Effect of Platelet-rich Plasma on Caspase-3 and IGF-1 mRNA expression in the diabetic rat testis

Effect of Platelet-rich Plasma on Caspase-3 and IGF-1 mRNA expression in the diabetic rat testis

Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020

Orthobiologics for the Hip Region: A Narrative Review

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