Efficacy of a pectin‐lecithin complex for treatment and prevention of gastric ulcers in horses

Sanz, Macarena G.; Viljoen, Adrienne; Saulez, Montague N.; Olorunju, Steve; Andrews, Frank M.

doi:10.1136/vr.102359

Cited by 21 publications

(30 citation statements)

References 35 publications

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“…Although ineffective in feed deprivation models (Murray and Grady ; Sanz et al . ), the use of mucosal protectants such as the pectin‐lecithin complexes may be adequate in low–moderate risk environments, especially when used in combination with antacids where they have been shown to be beneficial (Sykes et al . ).…”

Section: Preventionmentioning

confidence: 99%

Rethinking equine gastric ulcer syndrome: Part 2 – Equine squamous gastric ulcer syndrome (ESGUS)

Sykes¹,

Jokisalo

2015

Equine Veterinary Education

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Summary It has recently been highlighted that significant differences in prevalence, risk factors and the response to treatment exist between ulceration of the squamous gastric mucosa and ulceration of the glandular gastric mucosa in the horse. In the first article in the series, the term equine squamous gastric ulcer syndrome (ESGUS) was used to describe disease of the squamous gastric mucosa with clinical signs and diagnosis discussed. The purpose of this article is to review the pathophysiology, risk factors, prevalence, treatment and prevention of ESGUS.

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Section: Preventionmentioning

confidence: 99%

Rethinking equine gastric ulcer syndrome: Part 2 – Equine squamous gastric ulcer syndrome (ESGUS)

Sykes¹,

Jokisalo

2015

Equine Veterinary Education

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“…Several dietary supplements preventing and supporting the gastric mucus layer are commercially available. An improved recovery of EGUS by feeding a commercial pectinlecithin supplement has been reported by Venner et al (1999) and Ferruci et al (2003), whereas Murray and Grady (2002) and recently Sanz et al (2014) could not find any preventive effect in a gastric ulceration model using an intermittent fasting protocol. Administration of magnesium oxide (MgO) resulted in a transient increase in the gastric pH of up to 6 (Murray and Grodinsky 1992).…”

Section: Introductionmentioning

confidence: 85%

Effects of different neutraceutic supplements on the gastric mucosa of weanling foals

Fedtke¹,

Fiedler²,

Venner³

et al. 2015

PHK

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Summary: Weaning can be a stressful period in foal's life resulting in increased prevalence of gastric ulcers which may lead to impaired rearing performance and economical losses. Beside medical treatment and optimizing housing and feeding conditions, dietary supplements have been proposed to reduce gastric mucosal lesions. Sixty-one warmblood weanlings from one stud farm, aged between 6 and 8 months were included in the study. During the experimental period, all foals were fed a total mixed ration (TMR) and hay ad libitum. After weaning, all foals were randomly and blindly allocated to one of three supplementation groups: group 1, control foals with no supplements; group 2, supplemented with MgO; and group 3, supplemented with a fermented preparation of herbs. Gastroscopy was performed prior to weaning and again after 16 days of feeding. Before weaning, the prevalence of gastric mucosal lesions was 82 % mainly found in the Curvatura minor of the Pars nonglandularis. After weaning, the prevalence was 96.7 %. The Antrum pyloricum and the Curvatura minor of the Pars nonglandularis showed a significant increase in gastric mucosa lesions after weaning in all groups. In both treatment groups, weaning resulted in a significantly higher lesion score in the Pars nonglandularis of the Curvatura major and on the pylorus and did not reduce the gastric lesion scores.

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“…On p 147 of this issue of Veterinary Record , Sanz and others (2014) report a prospective crossover study designed to assess the ability of an oral pectin-lecithin complex to prevent the development of ulcers in an experimental model. The evidence published previously regarding the efficacy of this complex in either preventing or treating equine gastric ulceration has been conflicting.…”

mentioning

confidence: 99%

“…The research was performed in 10 stabled horses, allocated randomly to intervention or control groups, before crossover for the second half of the study. Sanz and others (2014) implemented a 28-day treatment period for the complex in accordance with manufacturer recommendations, before induction of ulceration by a similar feed deprivation protocol (96 hours cumulative deprivation over seven days). The authors gastroscoped each horse at days 1 and 28 of the trial, and then again after feed deprivation (day 35).…”

mentioning

confidence: 99%

Equine gastric ulceration syndrome: treatment and prevention

Sutton

2014

Veterinary Record

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Efficacy of a pectin‐lecithin complex for treatment and prevention of gastric ulcers in horses

Cited by 21 publications

References 35 publications

Rethinking equine gastric ulcer syndrome: Part 2 – Equine squamous gastric ulcer syndrome (ESGUS)

Rethinking equine gastric ulcer syndrome: Part 2 – Equine squamous gastric ulcer syndrome (ESGUS)

Effects of different neutraceutic supplements on the gastric mucosa of weanling foals

Equine gastric ulceration syndrome: treatment and prevention

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