Efficacy of 5-Day Continuous Lidocaine Infusion for the Treatment of Refractory Complex Regional Pain Syndrome

Schwartzman, Robert J.; Patel, Mona; Grothusen, John R.; Alexander, Guillermo M.

doi:10.1111/j.1526-4637.2009.00573.x

Cited by 63 publications

(49 citation statements)

References 49 publications

(56 reference statements)

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“…One RCT found significant improvement in all pain parameters with a 5-mg/kg infusion; 17 a retrospective study of 49 CRPS patients found that 76% had at least 25% pain reduction 3 months after a 5-day lidocaine infusion. 18 …”

Section: Anestheticsmentioning

confidence: 97%

Modalities for Complex Regional Pain Syndrome

Zimmerman

Astifidis

Katz

2015

The Journal of Hand Surgery

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Section: Anestheticsmentioning

confidence: 97%

Modalities for Complex Regional Pain Syndrome

Zimmerman

Astifidis

Katz

2015

The Journal of Hand Surgery

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“…However, prolonged relief has been reported in animal models [274] and in some non-randomized [255,275] and randomized trials [175,276,277]. The Canadian Pain Society states that "intravenous lidocaine infusions are generally safe and can provide significant pain relief for 2-3 weeks at a time" [278].…”

Section: Selection Criteria For the Use Of Ivlt In Paediatric Chronicmentioning

confidence: 99%

“…Early recognition and appropriate '3P' management is the key to success. Within the context of the coordinated multi-disciplinary approach, IVLT can serve as a useful adjunct to concurrent physical, and psychological interventions to manage chronic pain in children and youths [133,254,255]. IVLT needs to be explained and utilized in a way that does not negate the multi-disciplinary teams attempts to promote self-management and de-medicalization.…”

Section: Multi-disciplinary Team Management Of Children With Chronic mentioning

confidence: 99%

“…Clinical studies show analgesic effects of intravenously administered sodium channel blockers especially in pain conditions where hyperalgesia is prominent [114,139,143,144,276,277,[280][281][282]. Chronic pain conditions, in which reports of IVLT have been beneficial include peripheral nerve injury [283], neuropathic pain [7,16,274,276,279,[284][285][286], CRPS [255,287], headaches [133,288,289], cancer therapy, spinal cord injury [176] and fibromyalgia [290].…”

Section: Selection Criteria For the Use Of Ivlt In Paediatric Chronicmentioning

confidence: 99%

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A Review of Intravenous Lidocaine Infusion Therapy for Paediatric Acute and Chronic Pain Management

Lauder¹

2017

Pain Relief - From Analgesics to Alternative Therapies

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Pediatric acute and chronic pain experiences involve the interaction of physiological, psychological, behavioural, developmental, pharmacological and situational factors. In the acute perioperative pain setting preventative multimodal analgesia is required to provide comfort and minimise the potential for "wind-up" and central sensitisation. When pain is recurrent, ongoing or chronic some children embark on a downward spiral of decreased physical, psychological and social functioning. The multidisciplinary team management approach is a well-established standard of care for children with complex chronic pain. Intravenous lidocaine has peripheral and central mediated analgesic, anti-inflammatory and anti-hyperalgesic properties. Intravenous lidocaine infusion therapy (IVLT) has been shown to be effective in the management of acute and chronic pain in adults. This chapter will present the rational for IVLT in pediatric pain management with emphasis on preventative multimodal therapy in acute pain and the multidisciplinary treatment approach in chronic pain. Large multi-centre randomised controlled trials are required to provide the evidence-base to confirm that IVLT is indeed an effective and safe treatment option in acute preventative multimodal analgesia and as an adjunct in the multidisciplinary care of chronic pain in the pediatric population. Keywords

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“…She has been treated with both ketamine and lidocaine infusions for her CRPS. 5,6 The ketamine has shown benefit in terms of decreasing the diffuse erythema and swelling which occur intermittently over her entire body and face. Lidocaine infusions produce some relief of her pain.…”

Section: Introductionmentioning

confidence: 99%

Gardner-Diamond syndrome associated with complex regional pain syndrome

Edinger¹,

Schwartzman²

2013

J Dermatol Case Rep

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Background: Gardner-Diamond syndrome (GDS) is also known as psychogenic purpura, autoerythrocyte sensitization syndrome and painful bruising syndrome.Main observation: This is a case report of 27-year-old woman who presented with unexplained bruising and intramuscular hematomas after a seven year history of complex regional pain syndrome. Her evaluation consisted of hematological studies, skin and muscle biopsy; it failed to reveal an underlying coagulopathy, vasculitis or other demonstrable cause. In the absence of any other etiology, she was diagnosed as Gardner-Diamond syndrome. Conclusion:This patient is unique because of intramuscular hematomas and the association of Complex regional pain syndrome with Gardner-Diamond syndro-

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Efficacy of 5-Day Continuous Lidocaine Infusion for the Treatment of Refractory Complex Regional Pain Syndrome

Abstract: Intravenous lidocaine administration titrated to 5 mg/L demonstrated: 1) a significant decrease in mechanical and thermal allodynia for three months, 2) lessened associated inflammatory components of CRPS, and 3) only minimal side effects and no severe complications.

Cited by 63 publications

References 49 publications

Modalities for Complex Regional Pain Syndrome

Modalities for Complex Regional Pain Syndrome

A Review of Intravenous Lidocaine Infusion Therapy for Paediatric Acute and Chronic Pain Management

Gardner-Diamond syndrome associated with complex regional pain syndrome

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