Efficacy and tolerability of propolis special extract gh 2002 as a lip balm against herpes labialis: a randomized, double-blind three-arm dose finding study

Holcova, S.; Hladíková, Marie

doi:10.4236/health.2011.31010

Cited by 7 publications

(11 citation statements)

References 24 publications

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“…Dermatological studies [ 8 , 29 ] performed with the special propolis extract GH 2002 (with pollen, waxes and resins removed to reduce the risk of allergic reactions) confirm the in vitro results and verified that significant results were achieved in the treatment of herpes labialis, applying 0.5% of this active substance in a cream. Recently, a single-blind study in 379 herpes labialis patients showed significant therapeutic results in favor of a cream with 0.5% GH 2002 compared with aciclovir cream 5%, both for the primary parameter incrustation/healing and for the secondary parameters pain, itching, swelling and tension [ 9 ].…”

Section: Introductionmentioning

confidence: 74%

“…Antiviral effects of the special propolis extract preparation GH 2002 applied in this trial have been demonstrated in several open studies aimed on the treatment of herpes labialis [ 29 , 31 ] and herpes zoster [ 30 ], including an examination of the dose and effect [ 29 ]. A recent study under blinded conditions examined the effects GH 2002 against herpes labialis in patients included in the early stages of the episode [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…The results of a previously performed dose-finding study [ 29 ] were used for the case number calculation. In the dose-finding study in patients with herpes labialis, the dose group with 0.5% propolis extract had reduced the time to complete encrustation by approximately one day when compared to a 0.1% concentration.…”

Section: Methodsmentioning

confidence: 99%

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Lip creams with propolis special extract GH 2002 0.5% versus aciclovir 5.0% for herpes labialis (vesicular stage)

Jautová

Zelenkova²,

Drotarová³

et al. 2018

Wien Med Wochenschr

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Summary A lip cream with special propolis extract GH 2002 at a concentration of 0.5% (199 patients) was tested against aciclovir 5% (198 patients) in the treatment of episodes of herpes labialis under double-blind conditions. Upon inclusion, all patients were in the vesicular phase. Application was five times daily of approximately 0.2 g of cream to the entire upper and lower lip. The primary parameter was the difference in time between groups to complete encrustation or epithelization of the lesions. Secondary endpoints were the course of typical herpes symptoms (pain, burning and itching, tension and swelling), the global assessment of efficacy and the safety of application. The predefined clinical situation was reached after a (median) 3 days with propolis and 4 days with aciclovir ( p < 0.0001). Significant differences in favor of propolis were also found for all secondary parameters. No allergic reactions, local irritations or other adverse events occurred.

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Section: Introductionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

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Lip creams with propolis special extract GH 2002 0.5% versus aciclovir 5.0% for herpes labialis (vesicular stage)

Jautová

Zelenkova²,

Drotarová³

et al. 2018

Wien Med Wochenschr

Self Cite

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“…8 A clinical dose-finding study compared concentrations of 0.1%, 0.5%, and 1% of propolis extract GH 2002 in a lip balm for the treatment of herpes labialis. 9 The study resulted in the recommendation of 0.5% as a concentration with a sufficiently strong effect and an acceptable level of safety. The latter point was also examined and confirmed in an open observational study.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study with a Lip Balm Containing 0.5% Propolis Special Extract GH 2002 versus 5% Aciclovir Cream in Patients with Herpes Labialis in the Papular/Erythematous Stage: A Single-blind, Randomized, Two-arm Study

Arenberger

Hladíková

Holcova³

et al. 2018

Current Therapeutic Research

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Background and objectivesThis controlled single-blind trial compared the efficacy of a lip balm with propolis special extract GH 2002 at a concentration of 0.5% in the treatment of episodes of herpes labialis with that of 5% aciclovir cream.MethodsPatients in the erythematous/papular stage were randomized: 189 patients were treated with propolis cream, 190 patients were treated with aciclovir cream (intention-to-treat population). Application was 5 times daily. The primary parameter was the difference in median time to complete encrustation or epithelialization of lesions. Secondary parameters were the development of typical herpes symptoms (eg, pain, burning and itching, tension, and swelling), the global assessment of efficacy, and the safety of application.ResultsThe predefined clinical situation was reached after a median of 4 days with propolis and after 5 days with aciclovir (P < 0.0001). Significant differences in favor of the study preparation were found with all secondary parameters and symptoms. No allergic reactions, local irritations, or other adverse events were observed.ConclusionsA formulation of 0.5% propolis GH 2002 extract lip balm was found to be superior in the treatment of episodes of herpes labialis over 5% aciclovir cream in patients in the papular/erythematous phase upon inclusion. EudraCT Registration No. 2006-001971-38.

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“…Its antiviral, antibacterial and antiphlogistic as well as locally anaesthetic properties make propolis special extract GH 2002 especially suitable for local application, as demonstrated in clinical studies on the treatment of Herpes labialis [11] [12].…”

Section: Introductionmentioning

confidence: 99%

Clinical Study: Lotion Containing Propolis Special Extract GH 2002 0.5% vs. Placebo as On-Top Treatment of Herpes Zoster

Tomanová¹,

Holcova²,

Hladíková³

2017

Health

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Background: The aim of the clinical trial was to establish the contribution of propolis special extract GH 2002 as constituent of a lotion for the supportive treatment of Herpes zoster. Methods: 60 patients with diagnosed Herpes zoster were either treated with a propolis containing (n = 33) or an identical, but propolis-free lotion (n = 27) for 28 days, as an add-on therapy to oral antiviral treatment with aciclovir. Study parameters were the assessment of pain on a visual analogue scale, the assessment of the formation of new vesicles, and the safety of application of the preparation. Results: Improvement of pain was significantly better and quicker in the propolis lotion group (p < 0.001 at all visits). On day 3/4, the reduction of pain versus baseline was 54% versus 20% reduction in favour of propolis lotion. On day 14 the results were 80% versus 42% pain reduction. Healing of lesions was significantly quicker with the propolis-containing lotion: at visit 3 on day 7, 21% versus none of the patients showed a closed skin with or without crusting. After 14 days, the comparison showed 57.6% versus 25.9%. At least 50% of propolis-treated patients were lesion-free on day 14, versus day 28 in the control group (p = 0.013). The formation of new vesicles was also significantly suppressed. On day 3/4 the number of newly formed vesicles was 15 versus 25, on day seven the number of new vesicles was 4 versus 14 (p < 0.001). The advantage of propolis lotion was confirmed through the global assessment of efficacy by the physician, with 75.8 versus 33.3% "good" to "excellent" ratings already on day 3/4, 90.9 vs. 44.4% on day 7, and 100 vs. 74.1% on day 28 (p < 0.001). Skin tolerability was excellent, no allergic reactions, skin irritations or other adverse events were observed. Conclusion: The observations clinically confirm antiviral and anti-inflammatory effects of propolis special extract GH 2002 and at the same time demonstrate the benefits of the topical add-on to the systemic antiviral therapy of Herpes zoster.

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Efficacy and tolerability of propolis special extract gh 2002 as a lip balm against herpes labialis: a randomized, double-blind three-arm dose finding study

Cited by 7 publications

References 24 publications

Lip creams with propolis special extract GH 2002 0.5% versus aciclovir 5.0% for herpes labialis (vesicular stage)

Lip creams with propolis special extract GH 2002 0.5% versus aciclovir 5.0% for herpes labialis (vesicular stage)

Comparative Study with a Lip Balm Containing 0.5% Propolis Special Extract GH 2002 versus 5% Aciclovir Cream in Patients with Herpes Labialis in the Papular/Erythematous Stage: A Single-blind, Randomized, Two-arm Study

Clinical Study: Lotion Containing Propolis Special Extract GH 2002 0.5% vs. Placebo as On-Top Treatment of Herpes Zoster

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