Lip creams with propolis special extract GH 2002 0.5% versus aciclovir 5.0% for herpes labialis (vesicular stage)

Jautová, J; Zelenkova, Hana; Drotarová, Katarína; Nejdková, A; Grünwaldová, Božena; Hladíková, Marie

doi:10.1007/s10354-018-0667-6

Cited by 22 publications

(10 citation statements)

References 27 publications

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“…A following double‐blind, randomized, multicentre trial with 400 patients evaluated the effect of 0.5% GH 2002 lip cream, compared with 5% acyclovir, for the treatment of the vesicular stage of herpes labialis. This time, the primary endpoint was reached after 3 days with propolis and 4 days with acyclovir, and, also in this case, significant differences in favor of propolis treatment were observed for the secondary parameters 71 . Altogether, these results show the overall efficacy of the topical application of GH 2002 propolis extract against herpes labialis, irrespective of the stage of the disease, susbstantiating the activity against HSV‐1 previously observed in vitro.…”

Section: Antiviral Activitysupporting

confidence: 74%

The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases

Magnavacca

Sangiovanni

Racagni

et al. 2021

Medicinal Research Reviews

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Propolis is a complex natural product that possesses antioxidant, anti‐inflammatory, immunomodulatory, antibacterial, and antiviral properties mainly attributed to the high content in flavonoids, phenolic acids, and their derivatives. The chemical composition of propolis is multifarious, as it depends on the botanical sources from which honeybees collect resins and exudates. Nevertheless, despite this variability propolis may have a general pharmacological value, and this review systematically compiles, for the first time, the existing preclinical and clinical evidence of propolis activities as an antiviral and immunomodulatory agent, focusing on the possible application in respiratory diseases. In vitro and in vivo assays have demonstrated propolis broad‐spectrum effects on viral infectivity and replication, as well as the modulatory actions on cytokine production and immune cell activation as part of both innate and adaptive immune responses. Clinical trials confirmed propolis undeniable potential as an effective therapeutic agent; however, the lack of rigorous randomized clinical trials in the context of respiratory diseases is tangible. Since propolis is available as a dietary supplement, possible use for the prevention of respiratory diseases and their deleterious inflammatory drawbacks on the respiratory tract in humans is considered and discussed. This review opens up new perspectives on the clinical investigation of neglected propolis biological properties which, now more than ever, are particularly relevant with respect to the recent outbreaks of pandemic respiratory infections.

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Section: Antiviral Activitysupporting

confidence: 74%

The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases

Magnavacca

Sangiovanni

Racagni

et al. 2021

Medicinal Research Reviews

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“…Due to the high number of participants in this single study, we included the patients as soon as HSL occurred, leading to a higher number of enrolled females. Comparable studies also did not consider the unbalanced proportion of male to female participants in the recruitment 22,27,28 . This can be considered a limitation of this study, but the advantage of this study is the high number of participants.…”

Section: Discussionmentioning

confidence: 99%

Clinical Study on the Effectiveness of Three Products in the Treatment of Herpes Simplex Labialis

Boes

Goulioumis

Wechsler

et al. 2020

Sci Rep

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Herpes simplex labialis (HSL) is a viral disease that affects the perioral region. No guidelines recommending an effective treatment exist. The treatment of HSL with three different products was examined. Herpatch Serum, a film-forming patch, was compared to Compeed Patches, a set of semiocclusive hydrocolloid patches, and Zovirax Cream (ingredient: 5% acyclovir). In this prospective, randomized, examiner-blind study, 180 patients with recurrent HSL were split into three groups (Compeed: n = 60, Herpatch: n = 60, Zovirax: n = 60) and examined within 24 hours of HSL outbreak (DRKS Registration No.: DRKS00007786). The primary endpoint was healing time. The secondary endpoints were the reaction rate and quality of therapy evaluated by the Clinician's Global Assessment of Therapy (CGAT) and the Subject's Global Assessment of Therapy (SGAT) (0 = no response; 10 = excellent response), respectively. There was no significant difference among the healing times for the different products. The mean (95% confidence interval) was 9.67 days (9.11-10.22) for Compeed, 9.30 days (8.75-9.85) for Herpatch, and 9.80 days (9.30-10.30) for Zovirax. The reaction rate and quality of therapy (CGAT and SGAT) of Herpatch were significantly higher than those of Compeed and Zovirax. Within the study limitations, Herpatch proved to be an effective, non-antiviral alternative in the treatment of HSL.Herpes simplex labialis (HSL) is a worldwide infection of the oral and perioral regions caused by an infection with Herpes Simplex Virus type 1 (HSV-1) or, rarely, Herpes Simplex Virus type 2 (HSV-2). Despite the high prevalence of HSL, the disease has not yet been well characterized. The seroprevalence of HSV-1 in Germany was 78.4% from 2008 until 2011 1,2 . While many infections remain subclinical, other patients suffer from painful recurrent infections.Following the primary infection with HSV-1, the virus replicates at the site of infection and proceeds to travel retrograde down unmyelinated sensory fibres to the trigeminal ganglion, where it establishes latency 3 . Interfering triggers such as psychological or physiological stress, UVB radiation, trauma, menstruation, sideropenia or febrile illness can provoke the reactivation of the virus 4,5 .The course of disease in recurrent HSL generally involves several stages. Within the precursor stage, pain, tingling, or burning sensations in the affected area may occur. This is followed by the appearance of a macule, turning into a papule and leading to the formation of a vesicle. The vesicle bursts, and the formation of a soft scab is initiated. Subsequently, the soft scab is replaced by a hard scab. Over time, the scab falls off, and the lesion is fully healed without scarring 6-8 . While healing, the process is often accompanied by symptoms such as pain, discomfort or reduced self-esteem 6 . Complete healing takes seven to ten days 7 .The treatment of recurrent HSL turns out to be very difficult and variable. Because of the slight effects of diverse therapies, the infection represents a constant and...

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“…Patients with herpes labialis Lip cream with propolis (0.5%) produced a better effect than acyclovir in the treatment of patients with herpes labialis in the vesicular phase [200] Central Europe (constituent of a lotion)…”

Section: Central Europe (Lip Cream With Propolis)mentioning

confidence: 99%

“…Although little literature about the antiviral activity of propolis in clinical studies exists, in 2019, Jautová et al reported that one lip cream with propolis extract from Central Europe produced a better effect than acyclovir to treat patients with herpes labialis in the vesicular phase, confirming the clinical efficacy of lip cream composed of European propolis in the early and late start of treatment during an episode of herpes labialis [ 200 ]. Similarly, a clinical study reported the contribution of propolis extract from Central Europe as a constituent in a lotion for complementary treatment of Herpes zoster.…”

Section: Antiviral Activity Of Propolismentioning

confidence: 99%

Effects of Propolis on Infectious Diseases of Medical Relevance

Rivera-Yañez

Pozo-Molina

et al. 2021

Biology

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Infectious diseases are a significant problem affecting the public health and economic stability of societies all over the world. Treatment is available for most of these diseases; however, many pathogens have developed resistance to drugs, necessitating the development of new therapies with chemical agents, which can have serious side effects and high toxicity. In addition, the severity and aggressiveness of emerging and re-emerging diseases, such as pandemics caused by viral agents, have led to the priority of investigating new therapies to complement the treatment of different infectious diseases. Alternative and complementary medicine is widely used throughout the world due to its low cost and easy access and has been shown to provide a wide repertoire of options for the treatment of various conditions. In this work, we address the relevance of the effects of propolis on the causal pathogens of the main infectious diseases with medical relevance; the existing compiled information shows that propolis has effects on Gram-positive and Gram-negative bacteria, fungi, protozoan parasites and helminths, and viruses; however, challenges remain, such as the assessment of their effects in clinical studies for adequate and safe use.

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Lip creams with propolis special extract GH 2002 0.5% versus aciclovir 5.0% for herpes labialis (vesicular stage)

Cited by 22 publications

References 27 publications

The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases

The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases

Clinical Study on the Effectiveness of Three Products in the Treatment of Herpes Simplex Labialis

Effects of Propolis on Infectious Diseases of Medical Relevance

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