Efficacy and tolerability of oral lactoferrin supplementation in mild to moderate acne vulgaris: an exploratory study

Mueller, Edgar A.; Trapp, Sonja; Frentzel, Adrian; Kirch, Wilhelm; Brantl, Victor

doi:10.1185/03007995.2011.557720

Cited by 19 publications

(18 citation statements)

References 31 publications

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“…Our results are in partial agreement with previous studies showing the efficacy and safety of lactoferrin for mild to moderate acne, as well as a decrease in sebum levels . However, these past studies failed to detect a gender effect of lactoferrin in the reduction in total and comedonal lesions.…”

Section: Discussionsupporting

confidence: 92%

“…Since the milk‐derived lactoferrin used in this study has >96% purity, it contains negligible amounts of the other potentially acne‐promoting bioactive molecules. In contrast, other lactoferrin products only have 80% purity . Indeed, we were able to show a better range of percent acne reduction versus baseline in our study (32.7–36% median reduction; 22.7–39% mean reduction) compared to a noncontrolled study (20–23.5% mean reduction) at 8 weeks …”

Section: Discussionsupporting

confidence: 41%

“…Additionally, vitamin E and zinc have potent antioxidant and anti‐inflammatory properties that are important for skin health . The effect of lactoferrin against acne has only been demonstrated in either small or noncontrolled open label trials . Thus, we investigated the effect of an oral lactoferrin with vitamin E and zinc capsule formulation in an adequately powered, randomized, double‐blind, placebo‐controlled trial for mild to moderate acne vulgaris.…”

Section: Introductionmentioning

confidence: 99%

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A randomized, double‐blind, placebo‐controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris

Chan¹,

Chan²,

Santos³

et al. 2017

Int J Dermatology

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Lactoferrin is an iron-binding milk-derived protein that has shown antibacterial and anti-inflammatory effects in vitro and in vivo. The objective of this study was to determine the efficacy and safety of lactoferrin, combined with vitamin E and zinc, for mild to moderate acne vulgaris. In this randomized, double-blind, placebo-controlled trial, 168 subjects aged 13-40 years old were randomly assigned to take either a capsule formulation containing lactoferrin with vitamin E and zinc or placebo twice a day for 3 months. The primary outcome measure was a reduction in the number of acne lesions compared to placebo. A total of 164 subjects completed the study per protocol. The lactoferrin group (n = 82) showed a significant median percent reduction in total lesions as early as 2 weeks (14.5%, P = 0.0120), with the maximum reduction occurring at week 10 (28.5%, P < 0.0001) compared to placebo group (n = 82). Maximum reduction in comedones (32.5%, P < 0.0001) and inflammatory lesions (44%, P < 0.0001) was also seen at week 10 compared to placebo. Sebum scores were improved by week 12. No adverse events were observed during the trial. A twice daily regimen of lactoferrin with vitamin E and zinc significantly reduced acne lesions in people with mild to moderate acne vulgaris.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 41%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A randomized, double‐blind, placebo‐controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris

Chan¹,

Chan²,

Santos³

et al. 2017

Int J Dermatology

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“…Whey protein concentrates represent a mixture of globular proteins and it remains to be determined which whey milk protein isolates may have this acne-promoting effect. More particularly, some abundant low-whey proteins, such as lactoferrin, possess antimicrobial and anti-inflammatory activities and were shown to lead to an overall improvement in acne lesion counts in 2 independent studies [15,16]. It is, of course, not possible to disentangle the effects of whey protein consumption and other dietary attitudes, lifestyle habits and psychological characteristics which may be associated with bodybuilding [17].…”

Section: Discussionmentioning

confidence: 99%

Acne and Whey Protein Supplementation among Bodybuilders

Simonart¹

2012

Dermatology

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Accumulative evidence supports the role of nutritional factors in acne. I report here 5 healthy male adult patients developing acne after the consumption of whey protein, a favorite supplement of those engaged in bodybuilding. These observations are in line with biochemical and epidemiological data supporting the effects of milk and dairy products as enhancers of insulin/insulin-like growth factor 1 signaling and acne aggravation. Further prospective studies are required to determine the possible role of dietary supplements in the fitness and bodybuilding environment.

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“… 8 LF is present in myriad mucosal fluids, 9–13 but is most predominant in human milk, particularly in the colostrum during early lactation, where it has been suggested to promote the healthy growth and development of the gastrointestinal [GI] tract, 14 promote the growth of commensal bacteria, and deter the establishment of pathogenic bacteria and viruses. 15–17 LF has been previously used for its beneficial effects in several models of human health including dermal inflammation, 18 , 19 wound healing, 20 and infectious diseases. 19 , 21 , 22 …”

Section: Introductionmentioning

confidence: 99%

VEN-120, a Recombinant Human Lactoferrin, Promotes a Regulatory T Cell [Treg] Phenotype and Drives Resolution of Inflammation in Distinct Murine Models of Inflammatory Bowel Disease

MacManus

Collins

Nguyen

et al. 2017

Journal of Crohn's and Colitis

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Background and AimsInflammatory bowel disease [IBD] is characterised by a disruption of immune homeostasis, which is tightly regulated to protect against harmful pathogens yet not react to commensal antigens. Animal studies indicate that regulatory T cells [Treg] modulate the immune response to prevent IBD development. Lactoferrin [LF] is an endogenous anti-inflammatory pleiotropic protein secreted at high concentrations in colostrum and at mucosal sites. However, the effect of LF on specific T lymphocyte populations has not been studied. Here, we identify a novel mechanism by which a recombinant human LF, VEN-120, regulates T cell populations in health and disease.MethodsTwo murine models of intestinal inflammation, the dextran sodium sulphate colitis model and the TNFΔARE/+ model of ileitis, were used to study the anti-inflammatory and T cell modulating ability of VEN-120. Flow cytometry was used to evaluate T cell populations within the lamina propria and mesenteric lymph nodes, and to evaluate the effect of VEN-120 on CD4+ T cells in vitro.ResultsVEN-120 reduced inflammation in both models of IBD, accompanied by increased Tregs in the intestinal lamina propria. Treatment of CD4+ T cells in vitro resulted in an upregulation of Treg genes and skewing towards a Treg population. This in vitro T cell skewing translated to an increase of Treg homing to the intestinal lamina propria and associated lymph tissue in healthy mice.ConclusionsThese data provide a novel immunological mechanism by which VEN-120 modulates T cells to restrict inflammatory T cell-driven disease.

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Efficacy and tolerability of oral lactoferrin supplementation in mild to moderate acne vulgaris: an exploratory study

Cited by 19 publications

References 31 publications

A randomized, double‐blind, placebo‐controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris

A randomized, double‐blind, placebo‐controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris

Acne and Whey Protein Supplementation among Bodybuilders

VEN-120, a Recombinant Human Lactoferrin, Promotes a Regulatory T Cell [Treg] Phenotype and Drives Resolution of Inflammation in Distinct Murine Models of Inflammatory Bowel Disease

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