Acne and Whey Protein Supplementation among Bodybuilders

Simonart, Thierry

doi:10.1159/000345102

Cited by 42 publications

(35 citation statements)

References 31 publications

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“…Nutritional supplements such as whey proteins containing leucine used by athletes may trigger or worsen acne . Leucine stimulates the production of IGF‐1 …”

Section: Resultsmentioning

confidence: 99%

The influence of exposome on acne

Dréno

Bettoli

Araviiskaia

et al. 2018

Acad Dermatol Venereol

119

110

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Background Acne vulgaris is one of the main reasons for dermatological consultations. Severity and response to treatment may be impacted by various external factors or exposome.AimTo assess the impact of environmental factors on acne and to provide a comprehensive overview of the acne exposome.MethodsTwo consensus meetings of five European dermatologists and a comprehensive literature search on exposome factors triggering acne served as a basis for this review.ResultsAcne exposome was defined as the sum of all environmental factors influencing the occurrence, duration and severity of acne. Exposome factors impact on the response and the frequency of relapse to treatments by interacting with the skin barrier, sebaceous gland, innate immunity and cutaneous microbiota. They may be classified into the following six main categories: nutrition, psychological and lifestyle factors, occupational factors including cosmetics, as well as pollutants, medication and climatic factors. Moreover, practical considerations for the dermatologist's clinical practice are proposed.ConclusionExposome factors including nutrition, medication, occupational factors, pollutants, climatic factors, and psychosocial and lifestyle factors may impact on the course and severity of acne and on treatment efficacy. Identifying and reducing the impact of exposome is important for an adequate acne disease management.

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“…Nutritional supplements such as whey proteins containing leucine used by athletes may trigger or worsen acne . Leucine stimulates the production of IGF‐1 …”

Section: Resultsmentioning

confidence: 99%

The influence of exposome on acne

Dréno

Bettoli

Araviiskaia

et al. 2018

Acad Dermatol Venereol

119

110

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“…Whey proteins are milk serum proteins used as oral supplements to increase muscle mass . Several articles report the potential association of these proteins with acne …”

Section: Resultsmentioning

confidence: 99%

Acne and nutrition: hypotheses, myths and facts

Claudel¹,

Auffret²,

Leccia

et al. 2018

Acad Dermatol Venereol

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Acne is an inflammatory and multifactorial skin disease. Different external and internal factors, including air pollution, aggressive skincare products, medication, mechanical, hormonal and familial factors and, more recently, lifestyle and stress, have been suggested as having an impact on acne. Moreover, for many years nutrition was believed to cause or worsen acne. Over the last decades, however, it has become a dermatological doctrine that there is no direct association between diet and acne. Even if recent research has allowed to identify certain nutritional elements and behaviour that may impact on acne, including the excessive intake of dairy products and hyperglycaemic food, modern lifestyle nutrition, obesity and eating disorders, knowledge about the role of nutrition in the physiopathology of acne still remains sparse and hypotheses and myths continue to dominate the debate. Thus, further clinical and translational research is necessary to investigate and confirm the association between nutrition and acne.

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“…Placebo‐controlled studies have demonstrated that high glycaemic load diets aggravate acne, result in postprandial hyperinsulinaemia and increase serum levels of free IGF‐1 . Epidemiological as well as clinical evidence confirmed that milk and other insulinotropic dairy products induce or aggravate acne . Whey protein abuse by athletes and bodybuilders has recently been reported to induce acne flares .…”

Section: Western Diet Upregulates Insulin/igf‐1 Signallingmentioning

confidence: 99%

Potential role ofFoxO1 and mTORC1 in the pathogenesis ofWestern diet‐induced acne

Melnik

Zouboulis

2013

Experimental Dermatology

140

121

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Acne in adolescents of developed countries is an epidemic skin disease and has currently been linked to the Western diet (WD). It is the intention of this viewpoint to discuss the possible impact of WD-mediated nutrient signalling in the pathogenesis of acne. High glycaemic load and dairy protein consumption both increase insulin/insulin-like growth factor-1 (IGF-1) signalling (IIS) that is superimposed on elevated IGF-1 signalling of puberty. The cell's nutritional status is primarily sensed by the forkhead box transcription factor O1 (FoxO1) and the serine/threonine kinase mammalian target of rapamycin complex 1 (mTORC1). Increased IIS extrudes FoxO1 into the cytoplasm, whereas nuclear FoxO1 suppresses hepatic IGF-1 synthesis and thus impairs somatic growth. FoxO1 attenuates androgen signalling, interacts with regulatory proteins important for sebaceous lipogenesis, regulates the activity of innate and adaptive immunity, antagonizes oxidative stress and most importantly functions as a rheostat of mTORC1, the master regulator of cell growth, proliferation and metabolic homoeostasis. Thus, FoxO1 links nutrient availability to mTORC1-driven processes: increased protein and lipid synthesis, cell proliferation, cell differentiation including hyperproliferation of acroinfundibular keratinocytes, sebaceous gland hyperplasia, increased sebaceous lipogenesis, insulin resistance and increased body mass index. Enhanced androgen, TNF-α and IGF-1 signalling due to genetic polymorphisms promoting the risk of acne all converge in mTORC1 activation, which is further enhanced by nutrient signalling of WD. Deeper insights into the molecular interplay of FoxO1/mTORC1-mediated nutrient signalling are thus of critical importance to understand the impact of WD on the promotion of epidemic acne and more serious mTORC1-driven diseases of civilization.

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Acne and Whey Protein Supplementation among Bodybuilders

Cited by 42 publications

References 31 publications

The influence of exposome on acne

The influence of exposome on acne

Acne and nutrition: hypotheses, myths and facts

Potential role ofFoxO1 and mTORC1 in the pathogenesis ofWestern diet‐induced acne

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