Efficacy and Safety of Ultrasound-Guided Percutaneous Polidocanol Sclerotherapy in Benign Cystic Thyroid Nodules: Preliminary Results

Abstract

Objective To evaluate the efficacy and safety of percutaneous polidocanol injection (PPI) in treating cystic thyroid nodules. Materials and Methods A total of 158 cystic or predominantly cystic thyroid nodules (>80% cystic component) in 143 patients were evaluated. 114 patients with compressive symptoms or aesthetic complaints were offered PPI. 44 individuals without compressive symptoms and aesthetic complaints who were only followed up clinically were used as the control group. The efficacy and safety of PPI were evaluated for 1 month, 3 months, 6 months, 9 months, and 12 months of follow-up. Results In the PPI group, the mean baseline volume of 15.6 ± 18.9 cm3 reduced at the 1-month follow-up to 5.1 ± 5.6 cm3 (p < 0.001) and 0.6 ± 0.9 (p < 0.001), and nodules shrunk according to the time after PPI (p < 0.001). A complete response (if ≥70% decrease) to PPI at the 12-month follow-up occurred in 100% of the cystic or predominant cystic nodules. None of the nodules recurred at the 12-month follow-up after PPI. The side effects were mild. Twenty patients (17.5%) developed mild localized pain, and fourteen cases (12.3%) experienced mild or moderate fever after PPI. Conclusions PPI is a safe and effective alternative to treat benign cystic or predominant cystic thyroid nodules.

Comparison of Ultrasound‐Guided Percutaneous Polidocanol Injection Versus Percutaneous Ethanol Injection for Treatment of Benign Cystic Thyroid Nodules

“…Eighty‐two of the 97 cysts (82.83%) achieved therapeutic success, and only 2 of 97 patients (2%) had mind pain and mild fever. Our study also showed that US‐guided percutaneous polidocanol injection of benign cystic and predominantly cystic thyroid nodules was effective and safe . Therapeutic success of percutaneous polidocanol injection was obtained in 114 of 114 cystic nodules (100%) and 57 of 61 of predominantly cystic nodules (93.44%).…”

“…With its widespread availability, ease of use, and safety profile, polidocanol may be a potential alternative to ethanol for the treatment of benign cystic and predominantly cystic thyroid nodules. Our previous research showed that ultrasound (US)‐guided percutaneous polidocanol injection for benign cystic and predominantly cystic thyroid nodules is effective and safe . This study aimed to compare the efficacy and safety of US‐guided percutaneous ethanol injection and percutaneous polidocanol injection for the treatment of benign cystic and predominantly cystic thyroid nodules.…”

The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system

“… [ 41 – 44 ] 5 10.92 0.96 Megastigmatrienone Not found – 6 11.1 0.70 2-Cyclohexen-1-one, 4-(3-hydroxy-1-butenyl)-3,5,5-trimethyl- Not found – 7 11.78 0.90 Ethanol, 2-(dodecyloxy)- Antithyroid, supress varicose veins formation. [ 45 , 46 ] 8 11.96 0.44 Cedrol Prevent chemotherapy-induced alopecia, promote hair growth, anticancer. [ 47 – 49 ] 9 12.1 1.28 (E)-4-(3-Hydroxyprop-1-en-1-yl)-2-methoxyphenol Not found – 10 12.21 1.05 6-Hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one Not found – 11 12.4 0.35 5,5,8a-Trimethyl-3,5,6,7,8,8a-hexahydro-2H-chromene Not found – 12 12.71 5.24 (S,E)-4-Hydroxy-3,5,5-trimethyl-4-(3-oxobut-1-en-1-yl)cyclohex-2-enone Anticholinesterase and antioxidant [ 50 ] 13 12.94 0.44 1(2H)-Naphthalenone, 3,4,5,6,7,8-hexahydro- Not found – 14 13.07 0.93 N,N-Diethylhexylamine Not found – 15 13.11 1.98 Neophytadiene Not found – 16 13.18 0.58 Z-28-Heptatriaconten-2-one Not found – ...…”

Ultraschallgeführte lokalablative Verfahren zur Behandlung von Schilddrüsenläsionen

“…In einer von Yang und Kollegen durchgeführten Metaanalyse aus 19 Studien und 1514 behandelten Patienten ergab sich nach EA eine gepoolte Volumenreduktionsrate von 84% (95%-KI 79,4-88,5%) [11]. In neueren Studien findet das Sklerotherapeutikum Polidocanol (Äthoxysklerol) erfolgreich Anwendung [12,13].…”